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Biomedical subjects

K P Skandhan

Publications and source records attributed to K P Skandhan.

At least 19 recordsLinked to original sources
PubMed2006

The process of spermatogenesis liberates significant heat and the scrotum has a role in body thermoregulation.

The temperature in human testis is 2-3 degrees C less than that of body providing a suitable environment for sperm production. Pampiniform plexus play a major role in this. Authors question the full function of Pampiniform plexus; if it is sufficiently efficient to maintain the optimal temperature, why testes are not retained in abdomen. The present hypothesis states that during the process of spermatogenesis a large amount of heat is liberated as a bye product of energy utilization. Testes are purposefully kept away in the dangling scrotum to exclude the damage otherwise it would have caused to visceral organs from the heat it produced. The heat from testes is carefully liberated by scrotum. The thin skin with no subcutaneous fat, scanty hair distribution and presence of more sweat glands on it permits easy escape of heat. On exposure to cold, the scrotal surface area is minimized by rugosities for heat conservation and cremaster muscles lift testes closer to abdomen to provide heat to body.

Body Temperature↗
PubMed1994

Copper in split and daily ejaculates.

The authors studied the copper level in three splits of 21 ejaculates to locate the origin of copper in semen. The copper level was rich in the first split and poor in the second. The results indicated that copper is released from all portions of the genital tract and that the major share is from the prostate gland. Another group of 26 volunteers submitted their semen samples once a day for 10 days for a study of the role of copper in fertility. A gradual increase in sperm motility was observed from the first day. There was no consistency in the level of copper in this study, and it did not correlate with any of the semen parameters studied.

Adult↗
PubMed1993

Development of copper male contraceptive. Contribution of India.

In this review article the author discusses the possibility of making a male contraceptive with the inclusion of copper. The contributions made by different groups of workers in India towards this, are critically analysed. Aspermatogenic status of copper is recognised. The toxicity of copper on tissue is a great concern for continuation of this programme. Recently a hypothesis for slow delivery system of copper for functioning as aspermatogenic and spermatostatic was mooted. The veracity of the proposal is yet to be seen.

Contraceptive Agents, Male↗
PubMed1992

Abortion in India.

Explore the source record for details and available documents.

Abortion, Legal↗
PubMed1992

Review on copper in male reproduction and contraception.

The effect of copper on spermatozoa was studied as early as 1956 by Quatrefages, and has given rise to numerous studies and the assay findings have recurred in all the tissues of the male reproductive system, with considerable individual differences, the cause of which is not understood. Its role in the sperm is unclear, but it appears to be involved in spermatozoan mobility and it may also act at the pituitary receptors which control the release of LH. In the seminal fluid, the level of copper appears to fall in cases of azoospermia and to increase in oligo- and asthenozoospermia, but the findings of different authors are somewhat contradictory and some authors do not report any correlation between the seminal level of copper and the number of mobility of the gametes. It is true that the concentrations in the ejaculate vary considerably from one day to the next and that they also vary in different fractions from a single ejaculate. The toxic effects of copper on spermatozoa, which was demonstrated in 1850 by Quatrefages, has often been confirmed. Copper reduces the oxidative processes and glucose consumption, which reduces or abolishes mobility: this property is exploited in intrauterine devices. The use of copper for male contraception has given rise to experimental implantations at various sites within the male system: lumen of the deferens, epididymis, seminal vesicle scrotum and the mobility of the spermatozoa was abolished in all cases. Tissue toxicity makes it impossible to use this method in human practice.(ABSTRACT TRUNCATED AT 250 WORDS)

Contraception↗
PubMed1989

Male sex and heart disease.

When averaged on a daily basis, a man loses more iron in semen than a woman in her menses. This shows that periodical loss of iron in women is unlikely to be the factor protecting against heart disease.

Coronary Disease↗
PubMed1988

Menarche: prior knowledge and experience.

The purpose of this study was to determine the details of first menstruation and the differences between those who had knowledge of menstruation prior to menarche and those who did not. Information from 305 young women in India was collected regarding menarcheal bleeding pattern, disturbances in normal menstruation, and menarcheal age. Those who had knowledge prior to menarche considered it to be a normal physiological function, while those who did not were "appalled" and "horrified." Those having prior knowledge had a high rate of regularity, lower rate of dysmenorrhea, and earlier onset of menarche. The subjects were unanimous in their desire for more information to be provided prior to menarche.

Adolescent↗