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PubMed1992

Yeast perinephric abscess: report of a case and review.

We report a case of yeast perinephric abscess and review 11 other published cases. This rare entity occurs primarily in patients who have diabetes mellitus, who have recently undergone surgery, or who have urinary tract obstruction. The clinical illness is often subacute or chronic with nonspecific symptoms. Candida and Torulopsis species are the reported etiologic agents. Successful therapy usually consists of percutaneous or surgical drainage of the abscess. Overall mortality is 25%; however, no patient in this series died as a direct result of perinephric infection.

Abscess↗

PubMed1992

Immunity, microbial pathogenesis, and immunophilins: finding the keys, now where are the locks?

The discovery and clinical use of the immunosuppressants cyclosporin A, FK506, and rapamycin have greatly advanced solid organ and bone marrow transplantation. Though active as antibiotics against a variety of pathogens, their utility has been severely limited by toxicity. Research on the immunophilins, the major binding proteins of these drugs, has given new insights into protein folding and transport as well as mediators of signal transduction in mammalian cells. Microbial immunophilins may also have direct relevance to the intracellular survival of important human pathogens. Defining the mechanisms of enhanced virulence generated by these proteins holds great promise for understanding both the fundamental pathogenesis of these organisms and the immune response generated against them. Such an understanding may provide novel targets for the design of anti-infective agents as well as assist in the development of future immunosuppressives.

Amino Acid Isomerases↗