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Biomedical subjects

K Ostrowski

Publications and source records attributed to K Ostrowski.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

[Reversible renal failure in female patients with acute interstitial nephritis caused by cloxacillin].

Cloxacillin was not listed as one of the drugs causing the acute interstitial nephritis, yet. A case of a 50-year female patient treated with cloxacillin is presented. Therapy was followed by nausea, vomiting, myalgia and arthralgia, and the symptoms of the acute renal failure which completely diminished after prednisone therapy despite of co-existing peptic ulcer. Low doses of corticosteroids seem helpful in the treatment of the acute interstitial nephritis following therapy with cloxacillin even after a long time of the onset.

Acute Kidney Injury↗
PubMedDate not supplied

Early and transient osteopetrosis in microphthalmic MIB-rats.

Microphtalmic blanc mutation (mib/mib) displays a very mild form of osteopetrosis in rats. The autosomal recessive mib mutation shows pleiotropic expressions in homozygotes. Microphtalmia, absence of eye and skin pigmentation, retardation in the tooth eruption were observed in the mutants. Most bone abnormalities occurred in newborns. An increased radiological opacity of long bones, persistence of primitive bone in medullary cavities, reduced number of poorly differentiated osteoclasts in mandibulae, reduced number of mononuclear peritoneal cells as well as reduced number of mononuclear osteoclast precursors in peritoneal cell population were found. In 3 weeks old and in adult mutants, both bone structure and the number of mandible osteoclasts appear normal, but the number of blood monocytes, peritoneal cells and mononuclear osteoclast precursors in peritoneal cell population remain significantly lower than in the healthy littermates. These observations indicate that the early failure of osteoclast differentiation and maturation is transient in the mib/mib form of osteopetrosis.

Abnormalities, Multiple↗
PubMedDate not supplied

Differences in adhesion of urothelial cells to a panel of substrates are characteristic for established human urothelial cell lines differing in their transformation grade.

Eight human urothelial cell lines established and propagated in the Fibiger Institute, differing in their transformation grade as described by Christensen et al were brought into suspension and contacted with a panel of seven substrates, ie. Con. A, Fibronectin, WGA, Collagen IV, Laminin, PNA and artificial basal membrane. Cell adhesion was measured on big cell populations with the use of flow cytophotometry, measured samples contained nonadhering cells and fluorescent beads, added as an internal standard. It was found that the cell lines differed from each other by the kinetics of cell adhesion to the chosen panel. A higher percentage of cells belonging to established cell lines adhered to PNA, WGA or Con A coated surfaces than to laminin, fibronectin or collagen IV. The difference in adherence of cells to fibronectin, laminin or collagen IV coated surfaces makes differentiation between the single cell lines possible. Discriminant analysis of the total patterns of adhesion of all cell lines was used for comparison. The effect of trypsinization on the structure of the cell surface, accompanied by possible changes in adherence, was evaluated by comparison of the immediate results with those obtained with cells after 3 hours of recovery at 37 degrees C. It was found that all cell lines showed a better adherence to laminin after recovery. This is consistent with the published data on the high sensitivity of laminin receptors to trypsinization. On the other hand, the receptors for PNA, WGA and Con A were less expressed after the recovery period, as evidenced by a decreased adherence of the cells to these three substrates. The effect of recovery of cells on the amount of their receptors for fibronectin and collagen IV was different in different cell lines, but the direction of change for this pair of receptors was identical in a given cell line. In some instances the recovery period had no effect whatsoever on cell adherence. The different pattern of adhesion of cells belonging to established cell lines to the chosen panel of substrates can be used as a parameter for characterization of single cell lines, but it does not correlate with their grade of transformation.

Cell Adhesion↗
PubMedDate not supplied

In vitro studies of human bladder cancer.

Explantation and cultivation in vitro of 55 human biopsies of histologically normal urothelial tissue, and 63 biopsies from transitional cell carcinomas (TCC) revealed a primary success rate of about 75% and a secondary success rate of about 50% with no significant differences, between normal and TCC derived cultures. While only half of the subcultured biopsies of normal origin were able to grow for more than 4 passages all TCC derived cultures were able to do so. Based on morphology, life span, invasive growth into co-cultured fragments of embryonic chick heart, and tumorigenicity in nude mice the following transformation grades (TGr) were defined: Normal (TGr 0), non-malignant with prolonged, but finite life span (TGr I), premalignant with infinite life span but without tumorigenic and invasive potential (TGr II), malignant with infinite life span and tumorigenic and invasive properties (TGr III). Differentiation between TGr I - TGr III was possible by several other parameters, including cytological characteristics, molecular and immunological surface structure, relative oncogene expression, pyruvate kinase isoenzymes, DNA Repair, and growth pattern. However, in addition to these common characteristics, the individual cell lines of the various categories of transformation showed differences that allowed the identification of well defined cell lines and sublines.

Animals↗
PubMedDate not supplied

[Stereotaxic ventroposteromedial thalamotomy in the treatment. Clinical observations and physiopathological considerations].

In 6 patients the authors performed stereotaxic ventroposteromedial thalamotomy for abolition or reduction of pain. The operation produced lesions in the centrum medianum and parasfascicular nucleus. In 2 cases unilateral operation was performed contralaterally to the side of pain, in the remaining cases the operation was done bilaterally as a one-step procedure. Postoperative follow demonstrated that in 1 case improvement was completely absent, in 4 initial good effect was transient and pain returned after several weeks and in only 1 patient very good effect persists for over 12 months. In the light of these experiences and a survey of the pertinent literature the authors reach the conclusion that limited stereotatic lesion of the so called non-specific pain-transmitting thalamic nuclei produces permanent abolition or alleviation of pain in few cases only. The pathophysiology of pain is discussed in the light of these data.

Adult↗
PubMedDate not supplied

[Syringobulbia treated surgically].

The authors describe a case of syringobulbia in a 52-year-old patient treated surgically. Atlanto-occipital decompression and longitudinal medullotomy was done. A significant clinical improvement followed, deglutition disturbances disappeared and the general locomotor activity became much better.

Brain Diseases↗
PubMedDate not supplied

[Treatment of acromegaly by the surgical approach through the sphenoid bone. I. Clinical results].

Forty-five cases of pituitary adenomas with clinical characteristics of acromegaly treated surgically from an approach through the nose and sphenoid sinus are presented. After the operation the somatic features of acromegaly decreased in 66% of cases, headaches regressed in 88%, visual field defects disappeared in 20% of cases. Selective removal of pituitary microadenoma caused return of regular menstrual cycles in 12 women and in 3 of them successful pregnancy and labour resulted. In cases of extrasellar growth of the tumour no satisfactory clinical remission was obtained.

Acromegaly↗
PubMedDate not supplied

[Internal carotid artery aneurysm in the sella turcica area simulating pituitary tumor].

A giant aneurysm of the internal artery is described which was situated in the sella and simulated hormonally inactive hypophyseal adenoma. Axial computer tomography demonstrated a hypophyseal tumour. During operation from intranasal approach through sphenoid sinus massive haemorrhage developed but was controlled with fibrin sponge. Postoperative angiography demonstrated a giant aneurysm of the internal artery situated in the sella. Although this location of aneurysm is exceptionally rare, each case of inactive hormonally pituitary adenoma should be subjected before the operation to cerebral angiography.

Adenoma↗
PubMedDate not supplied

[Effect of cerebellar cortical electrostimulation on the frequency of epileptic seizures in severe forms of epilepsy].

The authors studied 14 patients with epileptic seizures occurring from one to about 20 daily despite monitored pharmacological treatment. Two pairs of silver, properly insulated electrodes were applied to the subtentorial surface of both cerebellar hemispheres through burr-holes. The cerebellar surface was stimulated once daily for 30 min to 1 hour with electrical current at 10 Hz, 1 msec, 1-7 V during 10 to 16 days. During that time epileptic seizures disappeared completely in 5 cases, in 6 patients their frequency was reduced to one seizure every several days, in 2 cases the improvement was slight and one patient failed to improve. After cessation of electrostimulation and removal of electrodes in most cases the seizures increased again in frequently gradually. Twelve months after the procedure in only 4 cases a significant improvement remained. The authors believe that this method of cerebellar cortex stimulation should be regarded as a trial before making decision about chronic implantation of cerebellar electrostimulator for selecting patients responding well to this treatment. This group amounts to about 30% of such drug-resistant cases.

Adolescent↗
PubMedDate not supplied

[Destruction of Forel's field in the surgical treatment of epilepsy. Preliminary report].

UNLABELLED: Stereoencephalotomy remains often the only therapeutic method in severe cases of drug-resistant epilepsy in which it is not possible to use the classic resection methods. In the light of literature data we chose Forel's field as the site for producing stereotaxic lesions since it is the most strategically situated site in the pathways of propagation of epileptic seizures. SURGICAL TECHNIQUE: we used Leksell's stereotaxic apparatus for the operations. The contrast medium for filling the ventricular system was Dimer X. The parameters used in accordance with Jinnnai were calculated from the intercommissural line. The clinical and electrophysiological features of these cases are reported. Eleven patients were operated upon who could not be qualified for other surgical treatment methods because of generalized EEG changes. The main criterion accepted for qualification of patients by us were frequent seizures (at least 1 daily) despite systematic treatment conducted under control of serum drug levels. The indication for selecting the side of the operation was preponderance of EEG changes or presence of any lateralizing signs in the seizures. The duration of follow-up sufficient for evaluating the effectiveness of the operation was obtained in 7 patients. The following results were achieved: very good in 1 case, good in 3, improvement in 2 and poor in 1. In the light of these preliminary observations we consider that unilateral destruction of Forel's field is an operation indicated in severe generalized seizures, especially in the primary generalized form.

Adolescent↗
PubMedDate not supplied

[Therapeutic efficacy of pyridinolcarbamate (Anginin) in patients with combined cerebral and peripheral arteriosclerosis].

A group of 20 patients (average age 55.5 yrs) with advanced arterioscleorosis obliterans and cerebral thrombosis were treated with pyridinolcarbamate. Anginin was given for 6 months, 1,5--2 g. per day. Observation period before, during and after the treatment lasted 2 yrs. Medical and psychological examinations were performed; laboratory test included: sphigmooscylography, photoplethysmography, EKG, EEG, cholesterol, triglyceridis and other routine biochemical blood tests. All data are statistically evaluated. Results. During Anginin treatment clinical improvement was noted in 8 cases, in 9 there was no change in neurological examination; 3 cases--deteriorated. Control examination 6 to 12 months after discontinuation of the treatment revealed no changes in 13 patients; 1 patient deteriorated and 6--died. There was improvement in blood circulation as shown by plethysmography and sphigmooscylography in patients with less advanced vascular changes and no change in cases with more advanced disease. In 75% of the patients there was statistically significant (p less than 0.001) decrease of cholesterol and in 50% of triglicerids (not statistically significant). In patients with advanced disease there was no clinical and EEG improvement, on the contrary 1/3 of them deteriorated clinically and in EEG. In cases with less advanced disease clinical improvement was recorded. Anginin seems to be a good drug for patients with moderately advanced combined peripheral and central arteriosclerosis.

Adult↗