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Biomedical subjects

K Oshiro

Publications and source records attributed to K Oshiro.

27 records · Page 2Linked to original sources
PubMed1980

Studies on monocomponent insulin. V. pharmacokinetics of soluble insulin preparations using in situ animal model.

Pharmacokinetics of soluble monocomponent insulin preparation was examined by using an in situ experimental model of rabbits. Rabbits were laparotomized under anesthesia, and prepancreatic duodenal vein, splenic vein, and hepatic artery were ligated, and cannulae were inserted into the hepatic vein, portal vein, abdominal aorta, and renal vein. After administration of the monocomponent insulin preparation, blood was drawn periodically from each cannula, exogenous insulin level was measured, and kinetic parameters were calculated from the blood level curves from the arteries. The parameters obtained were disappearance rate constant (Kel) of 0.128 plus or minus 0.013 hr-1 and biological half-life (T1/2) of 5.50 plus or minus 0.49 min. Rate of insulin uptake by each organ was calculated from the difference in arterial and venous blood levels at each time period and values were 12% for the lever and 31% for the kidney. No definite uptake was found in the digestive tract. Relationship between the potency of insulin and blood levels suggested that the minimum effective blood level of this insulin preparation was 20 - 30 microU/ml.

Animals↗
PubMed1980

[Mortality rates by causes of deaths in the area aggregated by dyeing factories in Kyoto (author's transl)].

In 1971 and 1973, Yoshida, et al. reported a higher relative risk of urinary bladder cancer among the workers of dyeing factories in Kyoto city. In order to confirm this, death certificates in Kyoto city from 1969 to 1972 were retrospectively investigated. Kyoto city was devided into three areas, that is, areas with high, medium and low clusterings of dyeing factories, and the differences of the mortality rates of all causes of deaths among these three areas were examined. As a result of this study, a statistically significant difference of the mortality rate of bladder cancer could not be found for males. But, the relative risk of bladder cancer in the areas with high and medium clusterings of dyeing factories compared to the area with low was found to be 1.45. Therefore, the relationship between dyeing work and bladder cancer could not necessarily be denied. It is, thus, necessary to carry out a prospective study, by which a more precise result can be obtained. In addition, our study revealed a significantly high mortality rate of skin cancer among the areas with high and medium clusterings of dyeing factories for males, observing a relative risk of 3.88. The observed association between skin cancer and dyeing work should be further studied.

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