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Biomedical subjects

K Okamura

Publications and source records attributed to K Okamura.

At least 631 records · Page 35Linked to original sources
PubMedDate not supplied

Localized painful giant-cell thyroiditis without inflammatory signs in a euthyroid patient followed by serial sonography.

We describe a patient with localized painful giant-cell thyroiditis. A 45-year-old woman noticed a tender lump in the left side of the neck. Sonography of the thyroid revealed diffuse swelling of the left lobe with irregular hypoechoic areas. Three months later, the tender swelling subsided, and the hypoechoic areas disappeared without any treatment. There were never any systemic signs of inflammation or thyroid dysfunction. Atypical localized subacute thyroiditis was considered to be the most probable diagnosis based on fine-needle aspiration cytology and serial sonography. Serial sonographic evaluations are useful to avoid unnecessary surgery.

Biopsy, Needle↗
PubMedDate not supplied

Electrophysiological studies on the cultured cells obtained from transplantable pancreatic carcinoma in Syrian golden hamsters.

A pancreatic ductal carcinoma was established as a transplantable tumor line in an inbred strain of Syrian golden hamsters. Intracellular recordings of membrane potentials and input resistance were made from cultured cells obtained from the transplanted tumors using indwelling glass microelectrode. The mean value of the resting membrane potential was -46.5 +/- 1.8 mV (S.E.) (n = 13), while the mean resting input resistance was 21.2 +/- 4.3 M omega (S.E.) (N = 13). Dibutyryl cyclic AMP (2 X 10(-3)M) caused a marked hyperpolarization of about 30 mV accompanied by a reduction of input resistance. The transplantable tumor and its cultured cell line developed in this study have demonstrated their effectiveness as a reliable experimental model for use in pancreatic cancer research.

Animals↗