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Biomedical subjects

K Okabe

Publications and source records attributed to K Okabe.

At least 307 records · Page 17Linked to original sources
PubMed1979

Thorium dioxide granuloma of the neck with resultant fatal hemorrhage.

A 46-year-old man had a granuloma in the neck that was caused by extravasation of thorium dioxide (Thorotrast) by an angiographic procedure performed about 30 years previously. His chief complaints were dysphagia and dyspnea with mild hoarseness. Parital resection of the tumor was performed, but his symptoms were not ameliorated. The immediate postoperative course was unfavorable. The patient died four months after the operation from massive hemorrhages from the right common carotid artery.

Carotid Arteries↗
PubMed1977

Genetic characterization and high efficiency photosynthesis of an aurea mutant of tobacco.

A new tobacco (Nicotiana tabacum) aurea mutant was isolated from the progeny of a selfed variegated tobacco plant. The new mutant is termed Su/su var. Aurea. If the mutant is selfed, the seeds obtained give rise to four types of plants: green seedlings which correspond to the wild type; yellow-green seedlings which correspond to the earlier described Su/su; yellow seedlings which correspond to the new tobacco aurea mutant Su/su var. Aurea; and white lethal seedlings. The frequency ratio of the four phenotypes is 1:1:1:1. It appears that the mutation is due to two independent nuclear factors, su and aur, both of which have to be present in a heterozygous conditions, Su/su Aur/aur, to give rise to the new aurea phenotype. The aurea mutant Su/su var. Aurea has a reduced photosynthetic unit size which is approximately one-eighth of the wild type. Despite its chlorophyll deficiency, the plant grows well and exhibits maximal photosynthetic rates on a chlorophyll basis which are at least seven times higher than those of the green wild type provided the temperature and the light intensities are high enough. In contrast to the earlier described Su/su, the new mutant does not exhibit more photorespiration than the wild type. It appears that the factor aur causes either repression of photorespiration or an increase in the number of functioning photosynthetic units.

Journal Article↗
PubMed1976

Effect of reductones on glyoxalase I1.

The effect of some reductones on glyoxalase I prepared from animal and microbial origins has been studied. The enzyme was extracted from ox liver or baker's yeast and partially purified by ammonium sulfate fractionation, gel filtration and ion exchange chromatography. Aliphatic reductones such as ascorbic acid, ascorbic acid 3-phosphate and triose reductone showed strong to medium inhibition, while dehydroascorbic acid showed no inhibition. Kinetic analysis indicated that the inhibition mechanism of ascorbic acid was uncompetitive. Varying extents of inhibition were observed among three kinds of diphenols belonging to aromatic reductones. They were in the order of increasing inhibitory power resorcinol, hydroquinone and catechol for the ox liver enzyme, and catechol, resorcinol and hydroquinone for the yeast enzyme. p-Benzoquinone, an oxidized reductone, exhibited marked inhibition on both enzymes. Its action seemed due to reaction with amino and/or sulfhydryl functions of enzyme protein and those of glutathione, one of the substrates.

Animals↗