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Biomedical subjects

K Ohno

Publications and source records attributed to K Ohno.

At least 577 records · Page 32Linked to original sources
PubMed1989

A mutant rat with congenital skeletal abnormalities and polycystic kidneys.

The newly found mutant rat was characterized by small body size, shortened broad skull, slightly shortened limbs and flattened thorax due to shortened ribs and lordosis of thoracic vertebrae. Another distinctive feature of this mutant was polycystic kidneys. The reproductive ability was poor and it died at 6-11 months of age. These constitutional skeletal abnormalities and polycystic kidneys were found to be inherited by an autosomal recessive gene, to which the gene symbol, chi, was proposed.

Animals↗
PubMed1989

[Prosthetic rehabilitation with the removable partial dentures using telescopic crowns after removal of unsuccessful dental implants].

It is well-known that unsuccessful dental implants sometimes give rise to pronounced inflammatory bone resorption of the upper and lower jaw, and that in such cases it is practically much difficult to attain adequate prosthodontic rehabilitation after removal of the implants. On this study it is completely reported that two patients suffering from implant-induced osteomyelitis could be finely compensated for with the removable partial dentures using telescopic crowns after removal of the implants, and then the results are shortly discussed from the view of pathology, oral surgery and prosthodontics. In the first case a 52-year-old woman had been suffering from osteomyelitis of the right mandible due to the both bladevent and endodontic-endosseous implant, and in another case a 43-year-old woman had been suffering from osteomyelitis of the right maxilla due to the endosseous subperiosteal implant, and they had borne insufficient mastication on the affected side of the jaws. Several months after removal of the unsuccessful dental implants, they were rehabilitated with the removable partial dentures using telescopic crowns to recover and maintain good functions such as occlusion, mastication, cosmetics and speech, and oral and general health.

Adult↗
PubMed1989

[Serum and tissue concentration of tegafur and 5-FU after administration of tegafur suppository in patients with lung cancer--correcting the influence of residual blood in the tissue].

Tissue concentration of tegafur and 5-FU was studied in 25 patients with of primary lung cancer, given 2 x 750 mg of tegafur suppository daily preoperatively (total doses 3.75-9.75 g, mean 5.16 g). Furthermore, the influence of blood remaining in the tissue was corrected in the determination of tegafur and 5-FU concentration. The tegafur level in tumor tissue (9.614 +/- 5.739 micrograms/g) was significantly (p less than 0.01) low compared with those in serum and normal lung tissue (13.185 +/- 8.198 micrograms/ml, 12.954 +/- 10.048 micrograms/g). On the other hand, the 5-FU level in tumor tissue (0.124 +/- 0.208) was significantly (p less than 0.01, p less than 0.05) high compared with those in serum and normal lung tissue (0.019 +/- 0.013 micrograms/ml, 0.035 +/- 0.031 micrograms/g) and showed approximately 2.5 times more minimum effective concentration against tumor cells (0.05 micrograms/g). The results show that preoperative administration of 2 x 750 mg of tegafur suppository daily is effective for the transfer of tegafur and 5-FU to lung cancer tissue.

Adult↗
PubMed1989

[Mediastinal dissection of hepatocellular carcinoma with bilateral hilar and mediastinal lymph node metastasis].

A 54 year-old man, who had been operated for hepatocellular carcinoma 43 months before, complained of frequent cough. He had widening of mediastinal shadow on chest X-ray film and high level of alpha-fetoprotein (197 ng/ml). Under the diagnosis of metastasis to mediastinum of hepatocellular carcinoma, lymph node dissection was performed and disclosed large metastatic tumors in subcarinal, right tracheobronchial and left hilar lymph nodes. After operation, frequent cough disappeared and alpha-fetoprotein level fell to 38 ng/ml. Metastasis to the mediastinum without lung metastasis of hepatocellular carcinoma was recognized only 2.6% in non-operated cases in annual of pathological autopsy cases in Japan 1980 and 4 case reports were found in literature with large metastatic mass shadow in mediastinum of hepatocellular carcinoma.

Carcinoma, Hepatocellular↗
PubMed1989

[Complication related to operative procedure in lung cancer and mediastinal malignancy--report of 6 cases].

Of the patients who underwent surgical treatment for the respiratory system at our hospital over the past 9 years, 6 were postoperatively complicated with chylothorax, 1 with liquorrhea and the other one with paraplegia. Chylothorax occurred after mediastinal lymph node dissection which was carried out for the treatment of malignant tumors. In five cases, it occurred on the left side, and in the sixth case, it occurred on the right side. In 2 patients who received conservative treatment, there was no reduction in chyle outflow, and they died of cerebral infarction and sepsis. The other 4 cases were surgically treated. In 3 of them, the impaired site of the thoracic duct was confirmed by administration of Sudan III before surgery. We confirmed that early reoperation for the chylothorax after lung resection should be performed. Liquorrhea occurred from the 5th costvertebral joint which had been directly infiltrated by lung carcinoma. Fortunately, the postoperative course was uneventful, though the patient complained of dizziness and headache until 14 postoperative days. The case of paraplegia was caused by oxydized cellulose cotton that entered the epidural space via the intervertebral foramen. It was used for hemostasis in the 5th costvertebral joint. This case indicates that oxydized cellulose cotton, which swells when it absorbs water, should be carefully used for hemostasis around the nerves.

Adolescent↗
PubMed1989

Effects of human recombinant interleukin 5 and 3 on the differentiation of cord blood-derived eosinophils and basophils.

When mononuclear cells from umbilical-cord blood were cultured for 3 weeks, low concentrations of interleukin 3 supported the preferential growth of basophils, with eosinophils comprising a smaller proportion. These basophils contained 0.15-0.3 microgram histamine per 10(6) cells, and released histamine by the IgE-dependent and -independent stimuli. Interleukin 5 increased the number and proportion of eosinophils in a dose-dependent manner without affecting the proliferation of other cell types in the interleukin 3-supplemented cultures. These cultured eosinophils could be activated by platelet-activating factor.

Basophils↗
PubMed1989

[A longitudinal study on individual fluctuation of signs in accordance with TMJ dysfunction syndrome in adolescents].

There are no reports with regard to fluctuation of signs concerning the TMJ dysfunction syndrome in adolescents. Concerning this problems, we examined 145 children (70 boys and 75 girls) of junior high school age and 429 children (202 boys and 227 girls) of senior high school age for 2-years (total 3-years) longitudinally. The results obtained were as follows: 1. The incidence of the TMJ dysfunction syndrome involved 10.3% in 1984, 15.9% in 1985, 15.9% in 1986 of junior high school age students and 11.7% in 1984, 18.4% in 1985, 31.0% in 1986 of senior high school age students. 2. The incidence of the individual that at least once during the 3-years period showed some or multiple signs of TMJ dysfunction syndrome was 31.0% of junior high school age students and 39.8% of senior high school age students. The incidence of the individual that had shown no signs of the TMJ dysfunction syndrome at all during the 3-year period was 69.0% of junior high school age students and 60.4% of senior high school age students. 3. With regard to individual fluctuation of signs of the TMJ dysfunction syndrome, there was a total of 2.8% of junior high school age students and 5.1% of senior high school age students, signs being recorded for all 3-years. In 28.3% of junior high school age students and 34.5% of senior high school age students, signs fluctuated during the entire 3 years.

Adolescent↗
PubMed1989

[Analysis of factors influencing the accuracy of ejection fraction measurement based on the thermal washout technic--investigation in a model heart].

Evaluation of ejection fraction and ventricular volume is more difficult in the right side of the heart than in the left side. Thermal washout method in the right ventricle with the aid of a rapid response thermistor made it possible in the clinical practice, but its accuracy is uncertain. We attempted to elucidate what factors could influence the accuracy of the measurement of the right ventricular ejection fractions in a model circuit and artificial heart equipped with two one-way valves. Findings are as follow: 1) By ventricular injection of the cold water it is possible to evaluate the ejection fractions more accurately than by atrial injection. The latter technique measured the ejection fraction 8.4% lower than the actual values. 2) The first ejection fraction measured will be the most accurate among the serially obtained ejection fractions using a thermal washout curve. 3) When the ejection fraction is high, the ejection fractions calculated from the later part of a thermal washout curve will be falsely low. 4) When the cold water is injected through the catheter running in the circuit, the effect of the catheter cooling could not be neglected and ejection fraction will be measured falsely low. The temperature change is so small in the later part of the descending limb of the thermal washout curve, that the effect of catheter cooling and ventricular cooling will be exaggerated and the calculation of the temperature change will be measured falsely high. This seems to be the cause of our findings in this research.(ABSTRACT TRUNCATED AT 250 WORDS)

Hot Temperature↗
PubMed1989

[A case of renal capillary hemangioma].

This is a case of a 18 year-old female with capillary hemangioma of the left kidney. This tumor forms a well-demarcated solid mass showing a low grade contrast enhancement on CT, an echogenic pattern on sonogram, and hypovascularity on angiography. The radiologic findings on this tumor have wide variations in the previously reported cases.

Adolescent↗
PubMed1989

[CT findings of primary and secondary malignant lymphoma of the brain].

Eleven patients with primary brain lymphoma and three patients with secondary brain lymphoma were analysed in detail on the results from the CT studies. Almost all the lesions were found in the basal ganglia and periventricular regions. Leptomeningeal lesion was noted only in one case in the three cases with secondary lesions while no such lesions were revealed in the cases with primary lesions. On the contrast studies while almost all the lesions showed homogenous contrast enhancement, the central low density areas in the lesions were seen in the two lesions in the 28 primary lesions (7.1%) and in the one lesion in the 5 secondary lesions (20%). The leptomeningeal spread of the lesion and the more frequent central low density area in the lesion are considered to be the differential points of the secondary brain lymphoma from the primary brain lymphoma.

Aged↗
PubMed1989

[Angiographic findings of gallbladder cancer].

The patients with gallbladder cancer often accompany with chronic cholecystitis. This fact leads angiographic diagnosis difficult. So the angiographic findings of the chronic cholecystitis are first analyzed precisely and subtracting the angiographic findings of the gallbladder cancer from these gives us the pure (true) angiographic findings of the gallbladder cancer. Characteristic angiographic findings of the gallbladder cancer only are stretched cystic artery encasement (27/37 cases) and short straight tumor vessels "bristly vessel" (36/37 cases).

Aged↗
PubMed1989

[The result of extended thymectomy in patients with myasthenia gravis of pure ocular type].

We studied postoperative status of 14 patients with myasthenia gravis of ocular type who underwent extended thymectomy. Nine patients were in remission, three improved, and two unchanged. No patient became worse and died. The remission rates at one, three, five, and ten years after operation were 50.0%, 58.3%, 60.0%, and 80.0%. The palliation rates at one, three, five, and ten years after operation were 64.3%, 75.0%, 80.0%, and 100%. The remission rate at one year after operation in patients of ocular type was significantly (p less than 0.05) higher than that in generalized type (191 patients). The mean preoperative duration of symptoms in patients who obtained remission after surgery was 7.2 +/- 6.5 months, while mean duration was 85.6 +/- 45.8 months in those patients who could not obtain remission, indicating a significant difference (p less than 0.05) of duration of symptoms between two groups. Among 89 patients with generalized as well as ocular symptoms before extended thymectomy, 62 patients (69.7%) still complained of ocular symptoms and 48 patients (53.9%) had generalized symptoms with or without ocular symptoms in 1 to 12 years after operation. This result shows that ocular symptoms do not disappear more easily than generalized ones. We conclude that extended thymectomy should be performed even in patients with myasthenia gravis of pure ocular type.

Adult↗
PubMed1989

[Surgical treatment of pulmonary metastases from osteogenic sarcoma-significance of aggressive resection of bilateral multiple metastases and tumors invading adjacent organs].

The results of surgical treatment of pulmonary metastases from osteogenic sarcoma were analyzed. Total cases were 23 with mean age of 17.0 +/- 9.1. The number of operations were 46, and operative procedures consisted of pneumonectomy in 1, lobectomy in 3, partial resection in 37 and resection of adjacent organs in 5. The overall five-year survival rate from the first thoracotomy was 21%. This was significantly higher than prognosis of the previous cases with pulmonary metastases which were not resected (p less than 0.001). Three-year survival rate for the group with 5 or less metastases was 57%, whereas that for the group with 6 or more metastases was 0% (p less than 0.02). To assess both the number and the diameter of metastases, an index called number-size score (NS score) was introduced, which was the sum of the diameters of each metastatic lesion. The three-year survival rate for the group with NS score 6 or less was 73%, whereas that for the group with NS score 7 or more was 9% (p less than 0.001). Disease free interval, the time of operation and histological effect of chemotherapy were not significantly related with prognosis. There was no long-term survivor among the patients with resection of adjacent organs. In conclusion, an aggressive resection of pulmonary metastases from osteogenic sarcoma should be performed with intensive chemotherapy, but significance of the resection of multiple metastases more than 20 or tumors invading adjacent organs is doubtful.

Adolescent↗
PubMed1989

[Study on indication of unilateral pulmonary artery occlusion test in patients undergoing pneumonectomy].

We tried to establish an indication of unilateral pulmonary artery occlusion test (UPAO), by analyzing the preoperative data of UPAO, overall and regional pulmonary function tests, and arterial blood gas in 55 patients who were intended for pneumonectomy. Our limits of functional indication for pneumonectomy were PPA less than or equal to 25 mmHg or TPVRI less than or equal to 700 dyne.cm-5.m2. PPA correlated with the inverse of contralateral FEV1.0/BSA (FEV section 1.0) and DLCO/BSA (section DLCO), which were calculated by multiplying preoperative values by contralateral ventilation fraction. TPVRI correlated with age, the inverse of PaO2, the inverse of FEV section 1.0, and the inverse of section DLCO. Multiple regression analysis yielded the equation, TPVRI approximately p = 1120/section DLCO + 24800/PaO2 + 6.40 X Age -506. In order to make false negative zero, the values of each parameter were as follows: age greater than or equal to 55, PaO2 less than or equal to 85 mmHg, FEV section 1.0 less than or equal to 0.8 L/m2, section DLCO less than or equal to 6.0 ml/min/mmHg/m2 and TPVRI approximately p greater than or equal to 450 dyne.sec.cm-5.m2. The specificities of each parameter were 18.6%, 20.9%, 39.2%, 40.4% and 59.0%. Therefore, in order to make false positive patients least, the criteria of TPVRI approximately p greater than or equal to 450 dyne.sec.cm-5.m2 should be used.

Adult↗
PubMed1989

[Clinical assessment of uneven ventilation by factor analysis of Xe-133 washout scintigram].

Factor analysis (FA) was applied to 50 consecutive Xe-133 washout lung scintigrams, and its findings were compared with dynamic scintigrams of Xe-133 washout (DSW). Mean transit time (MTT) of radioactive xenon measured by FA also was compared with that measured by height/area (H/A) or two-compartment analysis (2CA). In 12 patients with normal DSW, FA separated and located two factors: one represented background activity, and the other uniform washout from the lung. In 31 out of 38 patients (82%) with abnormal DSW, FA separated the same areas where the washout was delayed on DSW. In 5 (13%) patients, FA diagnosed more areas of delayed washout than DSW. FA failed in 2 (5%) patients, but this failure was due to small number of counts of pixels. Diagnosis by FA was seemed easier than diagnosis by DSW in 95% of all patients by the authors' impression. MTT by FA (y) correlated with MTT by 2CA (x) in small groups of patients: in 9 patients in whom only one MTT was obtainable by FA (r = 0.75, p = 0.02, y = 4.2x + 1.9), and in 8 patients of normal DSW in whom two MTT's were obtainable by FA (r = 0.77, p = 0.02, y = 0.69x + 6.2, y; shorter MTT by FA between the two). MTT by FA did not correlate with MTT by H/A. In conclusion, FA is useful for diagnosing uneven Xe-133 washout from the lung.

Adolescent↗