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Biomedical subjects

K Ohara

Publications and source records attributed to K Ohara.

At least 487 records · Page 27Linked to original sources
PubMed1976

Combined use of bleomycin in radiotherapy of a mouse mammary carcinoma.

Experiments were carried out to determine TCD50 (50% tumor control dose) of 3rd generation isotransplants of a C3H mouse mammary carcinoma treated or not treated with Bleomycin. If the antibiotic was injected 30 min before a single X-ray dose, TCD50 was reduced. This reduction in TCD50 was independent of Bleomycin dose of more than 15 mg/kg, because of the upward-concave nature of Bleomycin dose-cell survival curve. The combined effect, when tested by TCD50 assays, appeared less than additive. This effect was further examined by a series of TD50 assays which revealed that these tumor cells were capable of repairing the potentially lethal damage induced by X-rays and that induced by Bleomycin. It was also found that the potentially lethal damage after combined X-ray and Bleomycin treatments was repaired. These findings indicated that the combined X-ray and Bleomycin treatment resulted in additive effect if the repair of potentially lethal damage in tumor cells were taken into account.

Animals↗
PubMed1976

[Tularemia].

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Animals↗
PubMed1975

Prediction of survival time of rats in severe heat.

The response pattern of the rectal temperature of unanesthetized rats exposed to an acute heat in a room of 42.5 degrees C, rh 40% was analyzed in relation to survival time (S), equilibrium rectal temperature (Te), rise in Te from the initial temperature (Delta Te), and the slope of the changes in rectal temperature during the equilibrium period (Gt). A very wide fluctuation of the survival time (from 46.8 to 250.0 min) was observed between individual rats. For prediction of the survival time, following formula was obtained: log(S) = K1 - K2 times log (Te) - K3 times log (Delta Te) + k4 times 10- minus Gt. K1-4 are constants which differ according to sex. The predicted survival time showed highly constant results in individual rats when measured by repeated exposures. The predicted time coincided well with the survival time actually measured, the difference between the two (measured minus predicted) being 2.2 plus or minus 21.7 min (mean plus or minus SD) IN 77 RATS. There was also a significant correlation between the survival time predicted for acute heat exposure and the actual survival time of individual rats when they were exposed to a chronic heat by daily elevation of the rearing room temperature by 1.0 degrees C.

Adaptation, Physiological↗
PubMed1975

Reassessment of selectivity index in nephrotic syndrome with special reference to the clinical significance of a small-molecular IgG fraction in the urine.

The selective index O and the transR IgG have been valuable in clinical use, but they do not appear to always correctly reflect the GBM sieving effect on plasma protein and thus do not correctly predict the response to steroids. We applied a new technique to 22 nephrotic patients with the following results. (a) Fragments of IgG molecules (M-IgG, MW 5-10 X 10(4); S-IgG, MW 1-5 X 10(4)) were present in the urine in addition to normal IgG (L-IgG). These fragments were immunologically identical with the intact IgG molecule and therefore, could falsely portray GMB permeability. (b) The data strongly suggest that the S-IgG fragment found in the nephrotic urine is the IgG-Fc fragment present in increased amounts in such urine. (c) IgG L/S shows a positive correlation with O and transR IgG and can be used as a new and better selectivity index of GBM permeability. This, in turn, may provide a more accurate means of predicting the response to steroid therapy. For example, in the cases we analyzed, the transR IgG and O were incorrect in 31.9% and 22.7%, respectively, whereas with our new method they were incorrect in only 13.6%.

Adrenal Cortex Hormones↗