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Biomedical subjects

K Ogoshi

Publications and source records attributed to K Ogoshi.

At least 91 records · Page 5Linked to original sources
PubMed1987

Postoperative intravenous administration of lysine acetylsalicylate: effect on pain relief and platelet function.

The effects of lysine acetylsalicylate, a new injectable salicylate, on postoperative pain relief and platelet function were studied in ten men who had surgery for peptic ulcer. Four of five patients receiving lysine acetylsalicylate had satisfactory pain relief. One patient required an additional injection of 15 mg of pentazocine. Of the five patients in the control group, an average (+/- SD) dose of 90 +/- 23.7 mg of pentazocine was required to achieve adequate postoperative pain relief. Lysine acetylsalicylate decreased platelet aggregability but without resulting in hemorrhage. We concluded that this new salicylate administered intravenously to patients in the postoperative period provided adequate analgesia while allowing effective hemostasis despite its inhibitory effect on platelet aggregation.

Adult↗
PubMed1987

Effects of biological response modifier on thoracic duct lymphocytes in recurrent gastric cancer. Evaluation of OK-432, a hemolytic streptococcus preparation.

In 9 patients with recurrent gastric carcinoma treated with intracutaneous injections of a hemolytic streptococcal preparation of OK-432 (PIC), the T/B cell ratio, the number of IgG-Fc receptor positive (T gamma) cells, the degree of blastoid transformation of lymphocytes in response to concanavalin-A (Con-A) and phytohemagglutinin (PHA), and the activity of natural killer cells (NK) in the thoracic duct lymphocytes (TDL) and peripheral blood lymphocytes (PBL) were measured. In thoracic duct lymph, the T cell to B cell ratio was higher than that found in peripheral blood. The proportion of T gamma cells and the natural killer cell activity was found to be considerably lower in TDL than PBL, though there was a higher degree of blastoid transformation of lymphocytes in response to Con-A and PHA in TDL. After the administration of PIC, there was no significant difference in T/B cell ratios and T gamma cell proportion between TDL and PBL, though the lymphocytic blastoid transformation in response to Con-A and PHA decreased in TDL but not in PBL. PIC administration appeared to augument natural killer cell activity in both TDL and PBL.

Aged↗
PubMed1987

Effects of oral administration of streptococcal preparation OK-432 on thoracic duct lymphocytes.

One KE of streptococcal preparation OK-432 (PIC) was given orally to 6-week old male Wistar-Imamichi rats twice weekly, and control animals received comparable volumes of saline alone. Samples of thoracic duct lymph and posterior vena caval blood were collected prior to and 4 and 8 weeks following PIC. The T cell count of thoracic duct lymphocytes was about three times greater than that of venous blood specimens, and increased significantly in animals following PIC. Controls showed only a slight increase followed by a decrease, so that by 8 weeks of treatment with PIC, the thoracic duct T cell count revealed a significantly greater number in the PIC group than in the controls. In addition, after 8 weeks the per cent T cell subpopulation in thoracic duct lymph increased significantly in the treated group, but it declined in the control group. Concerning T cell subsets in thoracic duct lymphocytes, the percentage of suppressor/cytotoxic T cells showed a significant elevation in the control group after 4 weeks compared with the treated group. No other blood or lymph variables reached statistical significance in this respect.

Administration, Oral↗
PubMed1987

Hemolytic streptococcus preparation OK-432; beneficial adjuvant therapy in recurrent gastric carcinoma.

The administration of a hemolytic streptococcus preparation, OK-432, is thought to be of therapeutic value in the treatment of cancer patients through a stimulatory effect on the immune system. In order to evaluate any beneficial effect of such an administration, a group of patients with recurrent gastric cancer was studied. This group was randomly subdivided into 3 groups: 1) Intradermal group (ID Group), 42 patients given an intradermal injections of OK-432. 2) Intramuscular group (IM Group), 40 patients given an intramuscular injections of OK-432. 3) Control group (C Group), 39 patients not given injections. Each group was studied in regards to the length of survival, the host immune response and the incidence of side effects. When compared to the IM and C Groups, the ID Group showed improved survival. Accompanying this improved survival, the ID Group also had greater white cell and lymphocyte counts, a greater number of T cells, and a more dramatic skin reaction to the extracted cell wall polysaccharide of hemolytic streptococcus Su-strain (Su-PS). The ID Group, following OK-432 injection, had a 4.8% incidence of fever and a 52.4% incidence of local abscess formation at the injection site. 90% of the IM Group developed fever but abscess formation was absent in all patients. From these results, it was concluded that in the patients tested, intradermal injection of OK-432 appears to be clinically superior to intramuscular injection.

Adjuvants, Immunologic↗
PubMed1984

Effects of dopamine and substance P infusion on gastric acid secretion in Pavlov and Heidenhain pouched dogs.

The effects of dopamine and Substance P infusion on gastric secretion have been evaluated in Pavlov and Heidenhain pouched dogs. Basal gastric acid secretion was significantly inhibited during both dopamine and Substance P infusion in conscious pavlov pouched dogs. Substance P inhibited tetragastrin-stimulated gastric secretion much more than dopamine. These data suggest that the effects of dopamine and Substance P on gastric secretion depend on the vagal condition.

Animals↗
PubMed1984

[Basic and clinical studies on serum CEA levels using a new CEA-EIA (double monoclonal) kit].

Serum CEA levels were measured in normal subjects and in patients with benign and malignant diseases using a new Abbott CEA-EIA (double monoclonal) kit. The results of basic and clinical studies indicated that the correlation coefficient between serum CEA levels measured by a polyclonal CEA kit and serum CEA levels by the new kit was r = 0.976, and the reproducibility, stability and simplicity of this new kit were superior. The CEA levels were 1.68 + 0.11 ng/ml in normal subjects, and significant differences were shown between the two sexes, 1.81 + 1.67 ng/ml in the patients with benign diseases and a true positive rate of more than 7.0 ng/ml CEA levels was seen in 24.1% of the patients with malignant diseases. High positive rates were observed in patients with neoplasms, of the biliary tract and pancreas, then the colon, esophagus and stomach.

Adult↗
PubMed1984

[Clinical evaluation of tissue polypeptide antigen in patients with esophageal, stomach and colon cancer].

Serum tissue polypeptide antigen (TPA) levels were measured in 33 patients with esophageal cancer, 39 with stomach cancer and 50 with colon cancer. At the same time five glycoproteins, namely immunosuppressive acidic glycoprotein (IAP), alpha 1-antichymotripsin (alpha 1-ACT), acid soluble glycoproteins (ASP), sialic acid and carcinoembryonic antigen (CEA), were measured for comparison. The mean TPA values were 59.0 +/- 15.4 U/l in 61 normal subjects, 103.6 +/- 104.2 U/l (positive rate, 24.2%) in esophageal cancer patients, 111.9 +/- 49.8 U/l (71.8%) in stomach cancer patients and 124.8 +/- 195.5 U/l (40%) in colon cancer patients. The serum TPA levels in patients with stomach cancer rose with an increased number of involved lymph nodes and with a higher degree of infiltrative growth and increased with the advancement of tumor growth postoperatively. Serum TPA levels correlated well with those of alpha 1-ACT, IAP and ASP in stomach cancer patients and with those of CEA, ASP and sialic acid in colon cancer, but not in esophageal cancer patients. It is suggested that the serum TPA might represent one of the reactant proteins and/or tumor-associated antigens that appear to be dependent upon the cancer status.

Adult↗
PubMed1983

[Effect of PSK on cell-mediated immune status in the patients of stomach cancer].

Among 56 patients with stomach cancer preoperative cell-mediated immunity in relation to clinical staging was studied: eight cases were subjected to a control study in order to evaluate effects of PSK on cell-mediated immune status, preoperatively and postoperatively at 1, 3, 6, 9 and 12 months. They were given MMC and FT-207, and 4 of them (the study group) received PSK in addition. Preoperative study showed that WBC count, peripheral lymphocyte and T-lymphocyte tended to show a decrease as the disease progressed, whereas there was no major change in PHA response of lymphocytes. Postoperative study on 4 control patients showed that peripheral lymphocyte and T lymphocyte decreased, and that IgG X FcR+ T cells significantly increased during postoperative period. Four patients in the study group who received PSK, however, did not show these characteristics. It thus appears that PSK is effective in activating cell, while immunity during postoperative period, possibly by counterworking suppressor cells including IgG X FcR+T cells.

Adult↗
PubMed1983

[Immunosuppressive acidic glycoprotein (IAP) and immunosuppressive substance].

Serum IAP and IS levels were studied in patients with stomach cancer. We found that the serum levels of IAP and IS increased as the disease progressed; their true positive rates as tumor markers were 49.3% and 39.8%, respectively. There was some delicate difference between these glycoproteins and T-cell subpopulation. IAP and IS correlated well with a correlation coefficient of 0.847, their value in clinical oncology are thought to be equivalent. Some difference was found between their substances and ASP, this might indicate the heterogeneous nature of the circulating glycoproteins in varying cancer-bearing status.

Adenocarcinoma↗
PubMed1982

Analysis of the tissue and cellular localization of alpha-1-antichymotrypsin by an immunohistochemical technique.

The cellular localization of alpha-1-antichymotrypsin (alpha 1-ACT) was studied immunohistochemically using rabbit HRP-labeled Fab' against human alpha 1-ACT. alpha 1-ACT was found in cell nuclei of carcinomas of the stomach, liver, breast, pancreas and leiomyosarcoma and in cell nuclei of lymphoid cells infiltrated into the stomach carcinoma mass. alpha 1-ACT was not found in carcinoma cells of the colon, uterus, rectum or esophagus, or in lymphoid cells infiltrated into the rectal carcinoma mass or into inflammatory regions such as gastric ulcers or appendicitis. Further, alpha 1-ACT was not found in normal cells around the carcinoma mass or in normal tissues.

Breast Neoplasms↗
PubMed1982

The role of a serum DNA-binding protein (64DP) in the diagnosis of malignant neoplasms.

A DNA-binding protein with a molecular weight of 64,000 (64DP) has been found in elevated concentrations in the serum of patients with malignant diseases. 64DP has been found to be different from any previously described tumor markers, such as AFP, CEA, and C3DP. The results obtained with column SDS - polyacrylamide gel electrophoresis are as follows. 64DP is normally present in the serum at the concentration of 48 +/- 26 micrograms/ml (n = 49). The mean value of 64DP in 96 patients with untreated malignant disease was 167 +/- 67 micrograms/ml, whereas in 41 patients with nonneoplastic disease it was 61 +/- 23 micrograms/ml. No organ or tissue specificity seems to be required for malignant neoplasms to result in elevated serum 64DP concentrations. The clinical stage of the disease does no have much effect on the levels of 64DP and, even with histologically proven early lesions, the patients showed elevated levels of serum 64DP. Following successful surgical resection, 64DP tends to fall toward the normal value. Purification of 64DP was performed and its physicochemical properties have been defined. 64DP is a glycoprotein present in the alpha1-globulin fraction and it is rich in leucine, glutamic acid, and aspartic acid in its amino acid composition. More recently, using purified 64DP preparation, a single radial immunodiffusion assay system has been developed. According to the results of this method, the diagnostic accuracy of 64DP appears to be somewhat low and even marginal for certain types of commonly encountered surgical malignancies. Studies concerning the discrepancy between the results obtained by the two assay methods are now in progress.

Carrier Proteins↗