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Biomedical subjects

K O Smith

Publications and source records attributed to K O Smith.

67 records · Page 4Linked to original sources
PubMed1967

Viral hemorrhagic encephalopathy of rats.

A virus has been isolated and serially passed in suckling rats; it causes an acute fatal paralysis associated with hemorrhage and necrosis in the brain and spinal cord. The agent is relatively resistant to heat and ether, is about 20 millimicrons in diameter, and is antigenically closely related to rat virus. Its isolation resulted from the study of occasional cases of paralysis in adult rats after administration of cyclophosphamide.

Animals↗
PubMed1965

Architecture of the Adenovirus Capsid.

Smith, Kendall O. (Baylor University College of Medicine, Houston, Tex.), Warren D. Gehle, and Melvin D. Trousdale. Architecture of the adenovirus capsid. J. Bacteriol. 90:254-261. 1965.-The capsids of adenovirus type 2 were fragmented by treatment with low concentrations of sodium lauryl sulfate. The clusters of capsomeres resulting from this treatment displayed characteristic patterns. Some of these clusters, each consisting of nine capsomeres, interlocked so as to form the triangular facets of the viral icosahedron. There is some evidence which suggests that the capsomeres are connected to each other by filamentous structures located near their bases. Connections between capsomeres along the edges and at the vertices of the triangular facets were the first to break when particles were treated with sodium lauryl sulfate. Further treatment broke connections between other capsomeres. These data provide additional information concerning the capsomere arrangements and the fine structure of adenoviruses.

Journal Article↗
PubMed1965

Multiple-Tailed T4 Bacteriophage.

Smith, Kendall O. (Baylor University College of Medicine, Houston, Tex.), and Melvin Trousdale. Multiple-tailed T4 bacteriophage. J. Bacteriol. 90:796-802. 1965.-T4 phage particles which appeared to have multiple-tails were observed. Experiments were designed to minimize the possibility that superimposed particles might account for this appearance. Double-tailed particles occurred at a frequency as high as 10%. Triple- and quadruple-tailed particles were extremely rare. All attempts to isolate pure lines of multiple-tailed phage have failed. Multiple-tailed phage particles were produced in highest frequency by Escherichia coli cells in the logarithmic growth phase which had been inoculated at a multiplicity of about 2.

Journal Article↗