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Biomedical subjects

K O Lewis

Publications and source records attributed to K O Lewis.

28 records · Page 2Linked to original sources
PubMed1980

Early diagnosis of alcoholic cirrhosis by the aminopyrine breath test.

The aminopyrine breath test was assessed as an indicator of liver damage in a consecutive series of 49 chronic alcoholics admitted for detoxification. Mean 14CO2 excretion for those with compensated cirrhosis was 1.6%, compared with 6.8% for those with histologically normal livers, 4.3% for those with fatty change, and 4.0% for those with fatty change and fibrosis. All patients with cirrhosis had a value below the lower limit of normal (3.2%), whereas only 6 of the other patients had a subnormal value. Repeat studies after 7-10 days' abstinence showed that 14CO2 excretion increased in patients with compensated cirrhosis. In view of the poor prognosis of alcoholic cirrhosis once decompensation occurs, early identification of those at risk is important. The aminopyrine breath test was found to be a conventient and sensitive method for detecting early cirrhosis and lends itself as a screening procedure in the management of alcoholic patients.

Adult↗
PubMed1977

Aminopyrine breath test in alcoholic liver disease and in patients on enzyme-inducing drugs.

The 14C-aminopyrine breath test was used to measure liver function in 14 normal subjects, 16 patients with alcoholic cirrhosis, 14 alcoholics without cirrhosis, and 29 patients taking a variety of drugs. The normal value for the breath test was 8.6 +/- 1.5%, whereas it was significantly lower (5.1 +/- 3.8%) in patients with alcoholic cirrhosis. Higher than normal values were found in some alcoholic patients without cirrhosis and in patients receiving enzyme-inducing drugs, such as phenobarbitone. There was a significant correlation between serum gamma-glutamyltransferase and breath test in these groups. Some patients with alcoholic cirrhosis may also be capable of enzyme induction.

Adrenal Cortex Hormones↗
PubMed1975

Serum immunoglobulin and protein concentrations in Zambian African patients in Lusaka.

Serum immunoglobulins IgG, IgA, IgM and IgD and gamma-globulin, total globulin and albumin concentrations have been determined in 136 adult Zambian African hospital in-patients, with several diagnoses, in Lusaka, Zambia. The study gives base-line data for that population. A significant positive correlation between serum IgG and gamma-globulin concentrations (P less than 0.001) suggests that for routine use the less costly method for serum gamma-globulin determination gives equally useful information as that for IgG.

Adult↗
PubMed1973

The nature of the copper complexes in bile and their relationship to the absorption and excretion of copper in normal subjects and in Wilson's disease.

Copper in bile has been shown by electrophoresis to occur neither as free ions nor complexed to protein but to be associated with a component of the micellar complexes of bile. Solvent fractionation studies suggest that the bile salt components of the lecithin-bile salt complexes are the active binding agents. The effects of specific bile salts on the behaviour of copper during electrophoresis supports this possibility. The relationship of certain bile salts to the excretion of copper in man during the time that an external biliary fistula was functioning and to the intestinal absorption of copper in the rat was found to confirm this concept. The results show that copper in bile is associated with taurochenodeoxycholate and suggest an explanation for the elevated tissue copper levels found in Wilson's disease.

Animals↗