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Biomedical subjects

K Nygaard

Publications and source records attributed to K Nygaard.

At least 109 records · Page 6Linked to original sources
PubMed1977

Intestinal bypass. A comparison between two different bypass operations and resection of the small intestine in rats.

General nutrition, intestinal absorption and liver structure and function were compared in rats subjected to: 1) 90 per cent resection of the small intestine, 2) 90 per cent small intestinal bypass with end-to-side jejunoileostomy (ES bypass), and 3) 90 per cent small intestinal bypass with end-to-end jejuno-ileostomy and anastomosis between the excluded segment and the colon (E-E bypass). The E-E bypass group showed the highest mortality rate and the lowest body weight. In this group the haemoglobin concentration, the faecal fat excretion, and the liver function parameters were more abnormal than in resected rats. Rats with E-S bypass showed results in between the other two groups. In none of the animals was fatty infiltration or cirrhosis of the liver observed. It is concluded that intestinal bypass in rats has a more deleterious effect than resection, and this seems to be more pronounced when the excluded segment is anastomosed to the colon. Factors that might be responsible for this effect are discussed.

Alanine Transaminase↗
PubMed1977

Amyloidosis and Crohn's disease.

Amyloidosis associated with Crohn's disease was found in 7 patients among 85 subjected to intestinal resection for granulomatous enterocolitis. Most of the patients had symptoms of inflammatory bowel disease of relatively short duration before the diagnosis of amyloidosis was made and were without suppurative complications. Systemic involvement was seen in 6 of the patients. One died postoperatively from renal failure, and in 2 other patients kidney transplantation was performed because of deterioration of a pre-existent renal insufficiency. Six patients were alive 6 months to 10 years after amyloidosis was diagnosed. There is great risk of rapid deterioration of kidney function postoperatively in these patients. However, our experience suggests that in some cases the progression of amyloidosis may be delayed or even brought to a halt after surgical treatment of Crohn's disease.

Adolescent↗
PubMed1975

Reversible ureteral stenosis as a delayed complication of operation on the colon and rectum.

A non-direct ureteral lesion following operations on the colon and rectum is described. The complication was observed 10 to 64 days postoperatively, and is characterized by a unilateral or bilateral, relatively long stenosis. A total of 8 cases are presented: 7 of ulcerative colitis and one, a rectal prolapse. The main symptoms were unilateral abdominal or lumbar pain, moderate fever, and a pronounced ureteral stenosis revealed at i.v. urography. In 7 cases, full restitution occurred after antibiotic treatment, supplied by ureteral catheterisation in 4 cases, while operation was necessary in one case. The discrepancy between the seriousness of the roentgenological picture and the good final result of conservative treatment was striking.

Adult↗