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Biomedical subjects

K Nutahara

Publications and source records attributed to K Nutahara.

44 records · Page 3Linked to original sources
PubMed1989

Renal hypercalciuria and acidification defect in kidney stone patients.

Calcium metabolism and renal acidification ability were examined in renal stone patients. On a random diet 33 of 52 patients excreted more than 4 mg. per kg. body weight per day of urinary calcium and were entered into a second study on a 300 mg. calcium diet. Absorptive and renal hypercalciuria was differentiated by fasting urinary calcium (mg. per 100 ml. glomerular filtration). Every absorptive hypercalciuria patient tested and 5 renal hypercalciuria patients had a normal renal acidification ability, and the serum parathyroid hormone and urinary cyclic adenosine monophosphate levels were normal. By calcium restriction urinary calcium decreased more in absorptive hypercalciuria than in renal hypercalciuria (2.48 +/- 0.14 versus 3.34 +/- 0.27 mg. per kg. body weight per day, p less than 0.05). However, urinary calcium remained high in 76 per cent of the patients with absorptive hypercalciuria. Nine patients had a defect in renal tubular acidification and the calcium metabolism was similar to those with renal hypercalciuria. Present studies show that renal hypercalciuria and renal tubular acidification defect cannot be differentiated without an ammonium chloride test.

Acidosis, Renal Tubular↗
PubMed1988

Renal hypercalciuria and metabolic acidosis associated with medullary sponge kidney: effect of alkali therapy.

Sixteen patients with medullary sponge kidney (MSK) and renal stones underwent evaluation of calcium metabolism and acid base balance. Six normal subjects and eight patients with non-MSK absorptive hypercalciuria served as control. Nine (56%) were hypercalciuric and seven (44%) were normocalciuric (N-MSK). Hypercalciuria was divided into absorptive (AH-MSK, n = 2) and renal leak hyerpcalciuria (RH-MSK, n = 7). The mean of minimal urine pH of RH-MSK group (5.28 +/- 0.09 (SE] was significantly higher than that of normal control (4.78 +/- 0.12) and of non-MSK AH (4.80 +/- 0.6) during acute acid challenge. The mean of the arterial blood HCO3 concentration of RH-MSK group was significantly lower than that of two control groups. The urine calcium and a frequency of stone passage were decreased significantly after alkali treatment in RH-MSK.

Acid-Base Equilibrium↗
PubMed1985

[A case of malignant paraganglioma within the renal sinus].

A case of malignant paraganglioma within the renal sinus is presented. A 51-year-old woman underwent left transabdominal nephrectomy for renal tumor. Pathologically, the tumor was malignant nonchromaffin paraganglioma. This tumor seemed to originate from parasympathetic paraganglions around the left renal artery. Paraganglioma is rare in the literature. Especially, this may be the first report of such a lesion in the renal sinus.

Female↗
PubMed1984

Unilateral and segmental medullary sponge kidney: renal function and calcium excretion.

The renal acidification defect and renal hypercalciuria have been reported in patients with pan-renal and bilateral medullary sponge kidney. However, little is known about patients with unilateral or segmentally affected medullary sponge kidney. We report 2 cases of partially affected medullary sponge kidney with normal acidification ability and normal urinary calcium excretion, although the ability to concentrate urine was diminished. These findings suggest that in patients with partially affected medullary sponge kidney nephrolithiasis is not the consequence of renal hypercalciuria induced by systemic acidosis but is owing to the urinary stasis caused by cystic dilatation of the terminal collecting duct.

Adult↗
PubMed1984

Medullary sponge kidney and renal acidification defect.

Medullary sponge kidney ( MSK ) is one of the entities which comprises a subclass of renal cystic disorders. While the clinical signs, symptoms, and radiological findings have been well documented in the past, the literature concerning renal function in these patients is relatively sparse. Thus, the purpose of the present studies was to examine the renal function in 11 patients with MSK and compare them to seven healthy volunteers and ten control patients with bilateral renal stones. Patients with MSK had normal GFR, RPF, and capacity to dilute urine; however, their urine concentrating ability was diminished. Urine pH in MSK patients was higher than in control patients with NH4Cl administration, while titratable acid excretion was lower than normal. Steady-state plasma bicarbonate concentration was lower in MSK patients than in controls but arterial pH was within normal limits. These studies suggest that MSK patients have defects in urinary acidification and concentration mechanism which may, in part, be the result of functional abnormality of the terminal collecting ducts.

Acid-Base Equilibrium↗