Biomedical subjects

K Ntalles

Publications and source records attributed to K Ntalles.

11 recordsLinked to original sources

PubMed1998

Thyroid function in postmenopausal women with breast cancer on tamoxifen.

In 42 postmenopausal women with breast cancer, aged 48-85 years (mean age 62.4 years) serum thyroid hormone concentrations were measured before and after 6 months of tamoxifen therapy (20 mg daily). In particular triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), thyroxine-binding globulin (TBG) and thyroid-stimulating hormone (TSH) concentrations before and 30 minutes after thyrotrophin-releasing hormone (TRH) administration (200 microg i.v.) were measured before and 6 months after tamoxifen therapy. T3 and T4 concentrations increased significantly (p<0.001 and p<0.05, respectively) whereas FT3 and FT4 remained unchanged (p>0.05), TBG increased significantly (p<0.001) and basal TSH concentrations as well as TSH response to TRH injection increased significantly (p<0.05) after tamoxifen therapy. It is concluded that tamoxifen administration changes thyroid hormone concentrations. However free thyroid hormone levels remain unchanged and the patients remain euthyroid after long-term tamoxifen therapy.

Aged↗

PubMed1997

Sex hormones in postmenopausal women with breast cancer on tamoxifen.

In 42 postmenopausal women with breast cancer aged 48-85 (mean age 62.4) years, the blood sex hormone levels were measured before and after 6 months of tamoxifen administration (20 mg daily). Follicle-stimulating hormone and luteinizing hormone levels decreased after tamoxifen administration (p < 0.001), but remained in the postmenopausal range, oestradiol levels increased (p < 0.05), sex hormone binding globulin levels increased (p < 0.001), testosterone levels remained stable (p > 0.1), free testosterone levels decreased (p < 0.001), delta4-androstenedione, 17-hydroxyprogesterone, and dehydroepiandrosterone sulfate levels remained unchanged (p > 0.1), and basal prolactin levels and their response to thyrotrophin-releasing hormone injection decreased significantly (p < 0.001) after tamoxifen therapy. It is concluded that tamoxifen has many and diverse effects on sex hormone levels, and its adverse effects do not affect the biological status of the patient, except perhaps for oestradiol, that increases in some cases, whose possible effect must be studied.

Aged↗

PubMed1996

Paratesticular tumours in a patient with Nelson's syndrome.

An extremely rare case of a 39-year-old man with Nelson's syndrome and paratesticular tumours is presented. The patient had undergone bilateral adrenalectomy at the age 23 years for Cushing's syndrome. Later he developed skin and mucosal hyperpigmentation. Nelson's syndrome was diagnosed, and he underwent transfrontal hypophysectomy. At age 29, the presence of paratesticular tumours was noted which were excised together with the left testis. The preoperative levels of testosterone, produced by the paratesticular tumours, were extremely high; they fell after surgery.

Adrenal Hyperplasia, Congenital↗

PubMed1990

Bone mineral content of junior competitive weightlifters.

It is suggested that practicing various sports can increase the bone mineral content (BMC). However, we were unable to find any reports indicating BMC changes in weightlifting, a sport which involves both extremities and spine and increases muscle mass as well. Therefore, we thought that it might be of interest to measure BMC in junior competitive weightlifters. On the occasion of a recent Junior World Championship we measured, by single photon absorptiometry, BMC in 59 young competitive male athletes (aged 15 to 20 years) from 14 countries. Several variables were taken into account for each subject, including race, record, age, height and weight. Multiple regression analysis was performed in order to assess the contribution of the above mentioned variables to the variability of both distal and proximal BMC. Finally, athletes' BMCs were compared to matched sex and age normals. Our results suggest that junior competitive weightlifters have an increased BMC, well above the age-matched controls' mean. It seems that the vigorous exercise of weightlifters tends to fade out any race or age-related BMC differences. Finally, weightlifters' BMC seems to be highly correlated with body weight and record.

Adolescent↗

PubMed1989

Bone mineral loss related to menstrual history.

We measured the bone mineral content (BMC) of the forearm in 173 normal postmenopausal women. We also examined the relation between BMC and the chronologic age, the number of years elapsed since menopause, and the total number of menstrual cycles during the reproductive years. BMC had a better linear relation to the total number of menstrual cycles than with the years elapsed since menopause or with chronologic age.

Adult↗

PubMed1977