The effects of VDT work on urinary excretion of catecholamines.
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Biomedical subjects
Publications and source records attributed to K Noro.
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Cefbuperazone (CBPZ) was administered to inpatients with complicated urinary tract infections (UTI) at our department. Clinical efficacy and safety were evaluated in 22 chronic cases by the criteria for evaluation of clinical of antimicrobial agents on urinary tract infection. Overall clinical efficacy was excellent in 8 cases, moderate in 9 cases and poor in 5 cases with an effectiveness rate of 77%. Twenty-four of the 34 strains isolated from the patients were eradicated and eradication rate was 71%. Neither subjective nor objective adverse reactions were observed. Abnormal changes in laboratory tests were found in 9 patients, but were probably not related to CBPZ administration. Judging from these results, CBPZ is considered to be an effective and safe antibacterial for the treatment of complicated UTI.
A macroscopic industrial ecological model has been developed to investigate the effects of changes in industrial structure on social well-being in general and health in particular. The model is composed of the following sectors: industry and employment, environment and pollution, and population and health care. The model was calibrated using available data of the past 60 years for Japan. The simulation study was conducted with the time span of 1920 to 2000. The results indicated that the gradual shift, in the industrial structure of Japan, would improve the level of living standards resulting in enhanced health service capability and lower death rate although increasing adult disease rates in the aged society. Also the rapid future growths of service industry and information and communication were observed.
The working adaptation in VDT workers was conducted by investigating from two different standpoints: one was to indicate an improvement of working conditions and environments around the VDT workers, evaluating the fundamental data of their visual physiological functions, and the other was to investigate the relation between their performances and production. The results were as followed: 1. Eye strain induced by VDT work was able to take an objective view as accommodative and convergent depression including the tear productive function, followed by making good working conditions. 2. The measurement of eye movement was able to analyze the response time and the response process for the informations indicating on the display, and the concept of recovery time for deteriorated accommodative function was useful to improve the display design. 3. It was suggested that the measurement of visual evoked potential was more simple method to evaluate the workers' attention. 4. The relation between performance and psychological stress and the time course analysis of performance were studied, so that it was given suggestions as to assign suitably the work management and the working design to each VDT worker.
Antibody-dependent cell-mediated cytotoxicity (ADCC) was studied in 20 gastric and colorectal cancer patients by the microtest plate assay with sheep erythrocytes as the target cells. In cancer patients (with both good and poor prognosis), the peripheral K-cell level showed a significant decrease as compared with that of normal subjects. No meaningful difference of the K-cell level was observed between the good and poor prognosis groups. For the purpose of the follow-up of cancer patients, the determination of the K-cell level was useful only when time-lapse examination were performed in the same case.
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The cell-mediated immunity of gastric cancer subjects was investigated during the postoperative follow-up period from three to 12 months after surgery. The lymphocyte blastogenesis, the T cell count, the lymphocyte count and the lymphocyte percentage were significantly decreased in groups of experimental laparotomy and noncurative gastrectomy, compared with that of nonrecurrent cases after curative gastrectomy. The effects of the administration of immunopotentiators, the streptococcal preparation OK-432, and the protein-bound polysaccharide PSK, were studied in groups of curative gastrectomy. The lymphocyte blastogenesis, the T cell count and the lymphocyte count were slightly elevated in the OK-432 group.
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Visual display terminals (VDT) are popular in offices. Many VDT operators have complained about eye-function impairment. Experiments using an accommodo polyrecorder and an infrared optometer showed that visual tasks in VDT work might induce temporary effects in the visual accommodation system; prolonged the near point distance and the contraction time of accommodation and increased the low frequency component of the small fluctuation of accommodation after VDT work. The inhibition of accommodation caused by VDT work was more severe than that caused by the conventional hard-copy work, and changes in the accommodative function were found with statistical significance in the smaller-size character group but tended to deteriorate in the larger-size character group. The inhibition was more evident in the elderly and middle age groups than in the young age group. The inhibition of accommodation by VDT work might be inhibited by administration of methylcobalamin.
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The growth of ten strains of avian infectious bronchitis virus (IBV) in several cultured cells was examined. The cultured cells used were chick kidney (CK), chick embryo (CE), HeLa and BHK-21 cells. The results obtained can be summarized as follows. 1. All the strains showed similar growth curves in CK cells. Progeny viruses appeared in the culture medium 4 to 6 hours after inoculation and peak virus titers of 10(6.5)--10(8.5) TCID50 per 0.1 ml were obtained after 36 hours. A cytopathogenic effect (CPE) was detected within 24 hours. No distinct CPE and low multiplicities were observed on culturing at 30 degrees C. 2. All strains replicated in CE cells, although only small amounts of virus were produced. No CPE was observed. 3. Only Beaudette-42 and Holte strains grew in BHK-21 cells. 4. No IBV strains grew in HeLa cells.
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