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Biomedical subjects

K Noguchi

Publications and source records attributed to K Noguchi.

At least 559 records · Page 31Linked to original sources
PubMed1977

Azabicycloalkanes as analgetics. 3. Structure-activity relationships of 1-phenyl-6-azabicyclo[3.2.1]octanes and absolute stereochemistry of (+)-1-(3-hydroxyphenyl)-6-methyl-6-azabicyclo[3.2.1]octane and its 7-endo-methyl derivative.

A series of 53 1-phenyl-6-azabicyclo[3.2.1]octanes (1) has been tested for their analgetic and narcotic antagonist activities. Structure-activity relationships were investigated by varying the structural parameters. The most interesting compound in this series, the 1-(3-hydroxphenyl)-6,7-dimethyl derivative 8, shows the profile of a well-balanced antagonist-analgesic agent with a very mild physical dependence capacity. The absolute stereochemistry of its active enantiomer [(+)8] was established by the x-ray study and the chemical transformation to the phenylmorphan [(+)-II]. (+)-8 was stereochemically correlated also with the active enantiomer of the 7-demethyl derivatives [(+)-7] by chemical transformation and CD measurement. Certain structural and stereochemical correlations between these compounds (7 and 8) and other known antagonist-analgetics are discussed.

Analgesics↗
PubMed1977

Determination of uranium in human teeth, bones and tissues by the fission track method.

The uranium content of several human tooth, bone and soft tissue samples was determined by the fission tract method. The average uranium content in teeth, bones and soft tissues were 6.7, 8.4 and 64 ppb ash, respectively. The distribution of uranium in bones is less uniform than that of teeth, and the uranium content of soft tissues is generally higher than that of teeth and bone. The presence of thorium does not interfere with the uranium determination in most cases.

Bone and Bones↗
PubMed1976

[Effects of ferulic acid on FSH, LH and prolactin levels in serum and pituitary tissue of male rats (author's transl)].

The existence of substances in corn germ, which induce a positive response in pigeon crop test, has been previously reported by Okamoto and Takahashi in 1974. Following this first experiment, one of these substances was identified as ferulic acid by purification. In the present experiment FSH, LH and prolactin levels in the serum and the pituitary tissue of castrated male rats and EP (estradiol benzoate and progesterone) treated male rats were determined by radioimmunoassay at 5 to 180 min. after intravenous injection with 1 mg of ferulic acid. It was noted that FSH release only was promoted significantly at 5 min. after the injection, whereas LH and prolactin releases were inhibited at 5 to 10 min. after the injection. A rebound effect was noted in LH and prolactin releases after the injection.

Animals↗