Biomedical subjects

K Nihei

Publications and source records attributed to K Nihei.

94 records · Page 6Linked to original sources

PubMedDate not supplied

A case of Canavan disease: the first biochemically proven case in a Japanese girl.

Canavan disease (CD) has only been diagnosed on autopsy or brain biopsy, however, specific biochemical markers, such as N-acetylaspartic acid (NAA) and aspartoacylase activity, have recently been described in CD. We report a case of CD having the above biochemical markers. High levels of NAA were found in her urine, serum and CSF. Fibroblasts did not exhibit aspartoacylase activity. Clinically, she presented progressive psychomotor retardation, cerebellar signs, pyramidal signs and relative megalencephaly. CT and MRI showed findings of leukodystrophy. The evoked potentials showed widespread involvement in the brainstem. Magnetic resonance spectra showed a high level of NAA in the white matter. In Japan, this case is the first of CD determined on the basis of biochemical markers.

Amidohydrolases↗

PubMedDate not supplied

Changes in cerebrospinal fluid biotinidase activity in Staphylococcus aureus meningitis.

An early increase in activity of biotinidase in the cerebrospinal fluid (CSF) during the course of acute Staphylococcus aureus meningitis in a subject with subacute sclerosing panencephalitis (SSPE) is reported. A possible role of CSF biotinidase in the hydrolysis of specific opioid neuropeptides during acute inflammatory processes involving the CSF-central nervous system compartment is suggested.

Amidohydrolases↗

PubMedDate not supplied

Poliomyelitis-like syndrome following asthmatic attack (Hopkins syndrome).

A 12-year-old boy is described with a combination of right arm paralysis resembling poliomyelitis and severe asthma. At 4 years of age, he developed flaccid paralysis one day after a severe asthma attack. No etiologic factors could be found for his flaccid paralysis. Nineteen patients with similar poliomyelitis-like illnesses following asthmatic attack are reviewed.

Asthma↗

PubMedDate not supplied

The role of lymphatic drainage of the liver in gallbladder cancer: a case report.

We report a case of a patient with a unique lymph node relapse after right hepatectomy and aggressive lymph node dissection for gallbladder cancer. There was extensive involvement of the hepatic parenchyma from the primary tumor, but no extension to the lymph nodes or other adjacent organs. Seventeen months later, the patient underwent re-dissection of the retroperitoneal lymph nodes with right nephrectomy and partial resection of the vena cava because of lymph node recurrence at the hilum of the right kidney. This pattern of lymph node metastasis to the right side of the vena cava from gallbladder cancer invading the liver is probably due to the distinct lymphatic drainage of the liver.

Adenocarcinoma↗