Search PubMed⌕ Search

Biomedical subjects

K Nalini

Publications and source records attributed to K Nalini.

26 records · Page 2Linked to original sources
PubMedDate not supplied

Effect of intracerebroventricular methotrexate on brain amines.

Intrathecal methotrexate in children with leukemia is known to cause seizures, dementia, leukoencephalopathy and cognitive dysfunction. To investigate the role of brain amines in cognitive dysfunction, male Wistar rats were given multiple intracerebroventricular injections of methotrexate. Our earlier studies in this regard revealed disruption of brain monoamines in hippocampus with severe cytotoxic effect on CA4 hippocampal neurons. Further extending this study, the levels of brain monoamines in frontal cortex, hypothalamus and brainstem were estimated by HPLC method and histopathological study of the frontal cortex. The concentration of all three-brain amine (norepinephrine, dopamine and serotonin) levels was reduced in 2 mg/kg dose of methotrexate in frontal cortex and brain stem. Hypothalamus did not show any significant change in brain monoamine levels. No structural changes in the frontal cortex neurons were observed. Disruption of brain monoamines has been proposed as a cause of brain dysfunction from this chemotherapy. The outcome of the study may have therapeutic implications in the management of childhood lymphoblastic leukemia.

Animals↗
PubMedDate not supplied

Effect of drugs used in pulmonary edema (frusemide and combination of etofylline and theophylline) on surfactant system of lung.

Pulmonary surfactant activity of healthy male albino rats was estimated in terms of the maximum and minimum surface tension values of alveolar washings and the phospholipid content of the extract. The results obtained in these (control) animals were compared with those in two groups of animals treated with therapeutic doses of frusemide and a combination of etofylline and theophylline. A significant increase in surfactant activity in terms of surface tension values and phospholipid content was observed with frusemide, whereas a significant increase in phospholipid content without a change in surface tension values was observed in the case of combination of etofylline and theophylline. These findings suggest that frusemide in addition to its diuretic action, increases the surfactant activity of lung. This might be another mechanism by which it provides relief in pulmonary edema patients. The study also indicates that phospholipid concentration need not always reflect surfactant activity of lung.

Animals↗
PubMedDate not supplied

Circulating testosterone in pure motor stroke.

Serum LH, FSH and testosterone were quantitated in 9 patients with pure motor stroke within 24-48 h of its reported onset. High circulating LH with normal or low testosterone was noted in 8 of them. In response to an intravenous bolus of GnRH, the LH responses were exaggerated in all, but the FSH responses in 7 of them were comparable to those in eugonadal age matched controls. The rise in testosterone following 2000U hCG daily for 3 consecutive days was insignificant in the patients group compared to the controls. The data suggest normally operative pituitary testicular feed-back but decreased Leydig cell response in pure motor stroke.

Adult↗