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Biomedical subjects

K Naeser

Publications and source records attributed to K Naeser.

50 records · Page 3Linked to original sources
PubMed1987

Morphological changes and lens position 2 1/2 years after intracapsular cataract extraction with implantation of a semiflexible anterior chamber lens. A prospective re-examination.

Morphological changes and lens position were examined in 51 patients 25 to 38 (mean 30) months after intracapsular cataract extraction (ICCE) with implantation of the semiflexible, 3M, style 70, anterior chamber lens. Morphological changes presumably associated with the ICCE proper were: iris transillumination defects (68.6%), rupture of anterior hyaloid membrane (20%), detachment of posterior vitreous (42.9%) and anterior synecchiae (13.7%). The implant-related morphological changes were caused by iris tucking (19.6%), small, mobile lenses causing endothelial disturbance (9.8%), iris-haptic adhesions and progressive ovalling of pupillary form. The present morphological changes were compared with a previously published examination of the same patients performed 4 months after surgery: 9 eyes without tissue changes around the lens feet at the previous follow-up now had iris-haptic adhesions involving from 1 to 4 lens feet. In 8 eyes the iris-haptic adhesions had progressed. Compared with the previous examination the fraction of eyes with tissue changes at the lens feet had risen from 47.1 to 64.7%, while the number of eyes with oval pupils had increased from 54.9 to 80.4%. Contact between lens haptic and iris root seems to constitute a constant stimulus for structural changes of the iris.

Aged↗
PubMed1986

Complications and visual outcome 4 months after implantation of the semiflexible McGhan/3M, style 70, anterior chamber lens. A prospective study.

A report is given of visual outcome and intraocular complications in 64 patients 3-8 months after implantation of anterior chamber lens. 80% had a final visual acuity of 0.50 or better. Visual acuity below 0.50 could in most cases be related to pathological findings in the eye independent of implant. Pupillary block was found in 4 cases (6%), and at re-examination they all had gonioscopic changes. The mechanism of pupillary-block-glaucoma with IOL lens implantation and measures to meet this is discussed. Gross tucking was found to pre-dispose to chronic inflammation. Cystoid macular oedema (3%) and retinal detachment (2%) was found without obvious relationship to gonioscopic changes.

Aged↗
PubMed1986

Morphological changes after extracapsular cataract extraction with implantation of posterior chamber lenses. A prospective clinical study.

Morphological changes and lens position were examined in 66 patients 3 to 5.5 (mean 4) months after extracapsular cataract extraction with intended implantation of posterior chamber lenses in the ciliary sulcus. Important findings were: capsulotomy-requiring secondary cataract (3%), iris-lens synecchiae (18%), iris-capsule synecchiae (14%), pupillar capture (2%) and haptic-malposition (17%). The lens optic was slightly decentered in 33%. The internal anterior chamber depth was measured with optical pachymetry and averaged 3.5 mm (range 2.3-4.5 mm). The central distance between the posterior lens surface and the posterior capsule (LPCD) was measured pachymetrically and averaged 0.14 mm (range 0-0.6 mm).

Anterior Chamber↗
PubMed1986

Intraocular pressure in the first days after implantation of posterior chamber lenses with the use of sodium hyaluronate (Healon).

Intraocular pressure (IOP) was measured before and 6, 24, 48 and 72 h after extracapsular cataract extraction with implantation of a posterior chambers lens in 3 groups of patients. Group I (30 patients): Sodium hyaluronate (Healon) was used during anterior capsulotomy and lens implantation and was aspirated at the end of surgery. Group II (22 patients): Healon as in group I + 500 mg acetazolamide at the end of surgery. Group III (17 patients): BSS and/or air was used instead of Healon during surgery. In all groups statistically significant rises in IOP after 6 h were followed by significant falls in the remaining post-operative period. The rise and subsequent fall in IOP was significantly greater in group I than in group III. Acetazolamide in group II did not prevent excessive rises in IOP. Aspiration probably shortens the period of Healon-induced hypertension. We recommend a meticulous aspiration of Healon at the end of surgery.

Acetazolamide↗
PubMed1986

Complications and visual outcome 4 months after extracapsular cataract extraction with implantation of posterior chamber lenses. A prospective clinical study.

Sixty-seven patients were examined 3 to 5 1/2 (mean 4) months after intended extracapsular cataract extraction with implantation of the 3 M, style 83, posterior chamber lens. A visual acuity greater than or equal to 0.5 was recorded in 58 (86.6%) of the patients. The complications were: one (1.5%) case of acute iritis, one case of pupillary capture and two (3.0%) cases of capsulotomy-requiring early secondary cataract. There were no posterior segment complications. None of the patients were treated with anti-glaucomatous medication, and none had intraocular pressure above 20 mmHg. Pre-operatively, biometry was performed, and the SRK-formula was employed in estimating the post-operative spherical equivalent refraction: The actually measured refraction differed less than 2 diopters from the predicted refraction in 84.5% of the cases.

Cataract Extraction↗
PubMed1985

Intraocular pressure 4 months after implantation of the semiflexible McGhan/3M, style 70, anterior chamber lens. A prospective study.

Sixty-four patients were consecutively operated for senile cataract with implantation of the semiflexible McGhan/3M, style 70, anterior chamber lens. Intraocular pressure (IOP) was measured one day prior to the operation, 6 days and 3-8 months (mean 4 months) after the operation, and gonioscopy was performed one day prior to and 4 months after the operation. A significant fall in IOP was found in the operated eye 6 days after surgery. No significant change in IOP was found 4 months after surgery, neither in the operated eye nor in the non-operated fellow eye. Iris tucking seemed to have no influence on the post-operative tension, while a significant rise in IOP was found in 13 eyes with adhesions between the iris and lens haptics as the only abnormal gonioscopic finding.

Aged↗
PubMed1985

Gonioscopy after implantation of the semiflexible McGhan/3 M, style 70, anterior chamber lens. A prospective study.

Gonioscopy was performed in 64 patients 3-8 (mean 4) months after intracapsular cataract extraction with implantation of the semiflexible McGhan/3 M, style 70, anterior chamber lens. Iris tucking was present in 19 (30%) eyes. Iris-haptic adhesions (strands of iris-like tissue encircling the lens feet) were present in 24 (38%) eyes. Absence of iris tucking was statistically significantly (P less than or equal to 0.05) related to surgical expertise, while the occurrence of iris-haptic adhesions was independent of surgical experience. Pupillar deformation, usually an elongation in the axis of the implant, was present in 50%. The absence or presence of an abnormal gonioscopy could not with certainty be deduced from the form of the pupil. The majority of gonioscopically visible pathological changes in the chamber angle were located posterior to the trabecular meshwork.

Aged↗
PubMed1985

Intraocular pressure in the first days after implantation of the semiflexible McGhan/3 M, style 70, anterior chamber lens.

Intracapsular cataract extraction employing a corneal incision and with implantation of the semiflexible McGhan/3 M, style 70, anterior chamber lens was performed in a group of 25 patients with senile cataract. Intraocular pressure (IOP) was measured prior to and daily in the first 4 days after the operation. IOP was slightly, but significantly (P less than or equal to 0.05) lower in the observed post-operative period as compared to the pre-operative measurement. Similar results have previously been found after cataract extraction with an identical technique, but without lens implantation. This probably means that early post-operative intraocular homeostasis with respect to IOP is unaffected by the implantation of this type of lens. The fine regulation of early post-operative IOP is probably related to the fact that the described surgical technique usually is associated with only minor gonioscopically visible changes of the trabecular meshwork.

Aged↗
PubMed1982

Clinical evaluation of the Lotmar Visometer for macula testing in cataract patients.

This study is an independent clinical evaluation of the 'Lotmar Visometer', an achromatic interferometer that uses moiré fringes with variable pitch making quantitative assessment of macular function possible. Light source is a normal low-voltage lamp. We evaluated this instrument's ability to predict post-operative visual acuity in 90 consecutive cataract patients. 27% could not see the fringes. Among the rest of the patients the correlation between the instrument's prediction and post-operative visual acuity was generally poor. When used semiquantitatively or qualitatively, the visometer, however, can provide useful information of the macular function in some patients.

Adult↗
PubMed1980

Bioavailability and pharmacokinetics in man of orally administered theophylline.

The pharmacokinetics of theophylline after both intravenous and oral administration was investigated in six hospitalized patients with normal renal, hepatic and pulmonary functions. A rather wide range of biological half-lives from about 3-16 hours and plasma clearance values of about 1.5-115 ml kg-1 hr-1 were found in the investigated patients, who were from 31 to 73 years of age. The apparent volumes of distribution during the eliminatory beta-phase (Vdbeta) were within the range 0.394-0.6161 kg-1 with a mean value of 0.484 1 kg-1 +/- 0.082 S.D., as determined from the intravenous data, and in excellent agreement with the value obtained from the peroral data. Except in one case theophylline exhibited two compartment characteristics after intravenous administration, while the oral data in only one patient showed this pharmacokinetic configuration and had to be analysed according to one-compartment characteristics in the other five subjects. In the oral experiments absorption rate constants of from about 0.57 to 2.17 hr-1 were found for the administered microparticulate theophylline tablet preparation, Nuelin from Riker Laboratories. A wide range of lag-times from 0 to 1.32 hours were also demonstrated in the experiments. The systemic availability of theophylline in this preparation varied from 82.8 to 103% as determined on basis of the ratios of areas under the oral and intravenous serum concentration curves. It is conclusively stated that therapeutic plasma concentrations of theophylline probably may be maintained and controlled efficiently with the investigated oral theophylline preparation. Because of the interindividual variability in the biological half-life of the compound monitoring of the serum theophylline concentration is generally advised in order to avoid toxic side effects, in particular in relation to the initial establishment of a therapeutic serum concentration level in the individual subjects to be treated.

Administration, Oral↗
PubMedDate not supplied

Correlation between polar values and vector analysis.

PURPOSE: To evaluate the possible correlation between polar value and vector analysis assessment of surgically induced astigmatism. SETTING: Department of Ophthalmology, Aalborg Sygehus Syd, Denmark. METHODS: The correlation between polar values and vector analysis was evaluated by simple mathematical and optical methods using accepted principles of trigonometry and first-order optics. RESULTS: Vector analysis and polar values report different aspects of surgically induced astigmatism. Vector analysis describes the total astigmatic change, characterized by both astigmatic magnitude and direction, while the polar value method produces a single, reduced figure that reports flattening or steepening in preselected directions, usually the plane of the surgical meridian. There is a simple Pythagorean correlation between vector analysis and two polar values separated by an arch of 45 degrees. CONCLUSION: The polar value calculated in the surgical meridian indicates the power or the efficacy of the surgical procedure. The polar value calculated in a plane inclined 45 degrees to the surgical meridian indicates the degree of cylinder rotation induced by surgery. These two polar values can be used to obtain other relevant data such as magnitude, direction, and sphere of an induced cylinder. Consistent use of these methods will enable surgeons to control and in many cases reduce preoperative astigmatism.

Astigmatism↗