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K N Naresh

Publications and source records attributed to K N Naresh.

82 records · Page 5Linked to original sources
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Solid and papillary epithelial neoplasm of the pancreas. Diagnosis by fine needle aspiration cytology in four cases.

The cytologic features of four cases of solid and papillary epithelial neoplasm of the pancreas that were diagnosed on fine needle aspiration cytology are described. Papillary structures with delicate vascular cores covered with several layers of bland tumor cells were a distinctive feature. The papillae in two of the cases showed mucoid material in their cores. The cytologic features of solid and papillary epithelial neoplasm of the pancreas are distinct from those of other cystic pancreatic tumors.

Adolescent↗
PubMedDate not supplied

Parapharyngeal ganglioneuroma. Report of a case diagnosed by fine needle aspiration.

A case of ganglioneuroma presenting in a parapharyngeal location in a 4-year-old girl was subjected to fine needle aspiration cytology. A preoperative diagnosis of ganglioneuroma was subsequently confirmed on histopathologic examination. Only a few reports on the cytologic features of this tumor exist. The importance of considering this diagnosis for a tumor at an unusual site and in an uncommon age group is stressed.

Biopsy, Needle↗
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Medical colleges in India.

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Education, Medical, Undergraduate↗
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Preclinical studies on suicide gene therapy for head/neck cancer: a novel method for evaluation of treatment efficacy.

BACKGROUND: Malignancies of the oral cavity and oropharynx account for 31% of all diagnosed cancers in India. In most cases, patients present with tumours that are clinically stage III/IV where surgery, radiotherapy and chemotherapy have not been very effective. Hence, there is an urgent need for alternate treatment modalities. Gene therapy is a recent development shown to be effective in various malignancies. In this study we have attempted to cause bulk reduction in tumour volume using the HSVtk/ganciclovir strategy, solely on the basis of the 'bystander' effect. METHODS: Nude mouse xenograft tumours of human head/neck cancer were engrafted with cells expressing viral thymidine kinase. After treatment with 8 mM ganciclovir for 14 days, the treatment efficacy was monitored. A novel method has been devised to evaluate cell kill microscopically in the whole tumour. RESULTS: Of the 11 mice included in the study, 9 showed a significant reduction in total tumour volume of treated versus control tumours (p = 0.015). CONCLUSIONS: Bulk reduction in tumour load can be brought about without use of viral vectors for gene transfer solely by the bystander effect.

Animals↗