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Biomedical subjects

K N Hansen

Publications and source records attributed to K N Hansen.

32 records · Page 2Linked to original sources
PubMed1989

Sensitivity to tuberculin and sensitins from atypical mycobacteria (M. chelonae subsp. abscessus, M. avium, M. intracellulare, M. scrofulaceum) in 100 Danish school children.

One hundred non-BCG vaccinated Danish school children aged 7.3-14.9 yrs (median 12.8 yrs) were studied with regard to the size of skin induration 72 hrs following intracutaneous injections of 1 unit of tuberculin PPD and 0.1 microgram of four different sensitins produced from M. chelonae subsp. abscessus. M. avium, M. intracellulare and M. scrofulaceum. Fifteen children showed at least one significant reaction (i.e. skin induration greater than 6 mm). Of these children, 13 had two or more significant reactions. None of the children showed primary reactions to tuberculin; but the tuberculin reaction in one child was significant, whereas five other children had detectable tuberculin reactions, all being due to cross reactions to atypical mycobacteria. In addition to the atypical mycobacteria, the following frequencies of significant reactions were found: M. chelonae subsp. abscessus (6%), M. avium (11%), M. intracellulare (13%), M. scrofulaceum (12%). The reactions to the 5 skin tests were significantly different (p less than 0.001). However, the skin reactions to M. avium, M. intracellulare and M. scrofulaceum (i.e. the MAIS complex) were similar, and they correlated significantly (p less than 0.001). On the other hand, the members of the MAIS complex correlated with neither M. tuberculosis nor with M. chelonae subsp. abscessus, and the reactions to these two atypical mycobacteria were significantly different (p less than 0.01). This seems to indicate extensive cross reactions between the members of the MAIS complex. Consequently, cutaneous testing for this complex in epidemiological surveys only requires a skin test with one of the members.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1987

Posture-dependent chronotropic effect of carotid sinus massage.

The hypertensive carotid sinus can be divided into cardioinhibitory (chronotropic) and vasodepressor components; the former can be evaluated by carotid sinus massage performed in the supine position. We present the case of a patient in whom the abnormal cardioinhibitory response could only be demonstrated while in the sitting position.

Carotid Sinus↗
PubMed1985

Red cell 2,3-DPG, ATP, and mean cell volume in highly trained athletes. Effect of long-term submaximal exercise.

20 male elite long distance runners were compared to a control group of blood donors to determine the effect of training on red blood cells. The acute effects of exercise on red cells were investigated in 11 of the runners following a race of 15-30 km. The runners had elevated resting values of red cell 2,3-DPG (P less than 0.05) and mean cell volume (P less than 0.01); blood Hb and ATP were not different from concentrations in the control group. The red cell status of the athletes may be explained by an increased proportion of young erythrocytes in runners. No statistically significant changes in red cell 2,3-DPG, ATP, mean cell volume or blood Hb were found post exercise.

2,3-Diphosphoglycerate↗
PubMed1982

Muscle cell leakage due to long distance training.

Abnormal myoglobinemia (above 77 microgram/l) and free hemoglobin in plasma were found in 16 runners and in nine non runners immediately following distance running. The same abnormalities were found iun six elite rowers following rowing. In parallel with the rise in myoglobin and free hemoglobin a rise was found in serum concentrations of cellular enzymes (LDH, CK, ASAT, alkaline phosphatase) and of various metabolites. We found no proteinuria nor casts in the urine. Non runners had a higher rise in serum myoglobin than runners. Competitive running caused a rise in the serum concentration of the heart specific fraction of creatine kinase in seven of the nine (healthy) elite runners. The abnormal findings are only explainable on the basis of leakage of proteins from muscle cells to the circulation in otherwise healthy, well trained persons. Myoglobinemia and a transient rhabdomyolysis is a common phenomenon in long distance running, but evidently also occurs in distance rowing. Three months of running training prevented most of the muscle damage from relaxed jogging in the nine previous non runners. Neither the observed myoglobinemia nor the hemoglobinemia resulted in any significant loss of iron in the urine.

Adult↗
PubMed1979

Rapid and sensitive radioimmunoassays for human myoglobin.

A radioimmunoassay for quantitation of serum myoglobin in healthy individuals and patients with different diseases is described. Purified myoglobin was labelled by an 125I-labelled ester (N-succinimidyl 3-(-4 hydroxy, 5-[125I]iodophenyl) propionate), a commercially available antiserum was used, and the antigen-antibody complex was precipitated with polyethylene glycol 6000. The rapid assay can be performed within 1 h at 37 degrees C with a detection limit of 45 micrograms/l. Prolonged incubation at 4 degrees C for 18 or 72 h gives a detection limit of 6 and 2 micrograms/l, respectively. The mean coefficient of variation of the routine assay was 11%. In healthy human subjects a significant difference in mean serum myoglobin concentration was found between 43 women (34 +/- 17 micrograms/l) and 51 mean 47 +/- 15 micrograms/l). In twenty patients admitted to hospital with the clinical diagnosis acute myocardial infarction, the serum myoglobin concentration profiles were in close agreement with the final diagnosis. In three patients with myocardial infarction serum samples were taken every 2 h after the acute episode, and serum myoglobin levels were compared with the levels of creatine kinase, lactate dehydrogenase, aspartate aminotransferase and creatine kinase isoenzyme-MB.

Adult↗