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Biomedical subjects

K Mukuno

Publications and source records attributed to K Mukuno.

At least 55 records · Page 3Linked to original sources
PubMed1977

Innervation of melanocytes in human iris. An electron microscopic study.

Contacts between melanocytes and nerve terminals in human iris stroma were investigated by means of electron microscopy. Four distinct types of nerve terminal making synaptic contacts with melanocytes can be distinguished: (1) nerve terminals containing only empty synaptic vesicles (400-800 A in diameter) and with intervening basement membrane material (separation 1000 A); (2) nerve terminals with both empty vesicles and granulated vesicles (600-1100 A in diameter) also with intervening basement membrane material (separation 750 A); (3) nerve terminals containing empty vesicles and forming close contacts with melanocytes (distance about 400 A) without interposed basement membrane material, and (4) nerve terminals containg both empty and granulated vesicles (750 A in diameter) which make closer contacts with melanocytes (distance 270 A) without interposed basement membrane material. Type (1) and type (3) nerve terminals are thought to be cholinergic; type (2) and type (4) nerve terminals appear to be adrenergic. Taking into consideration these morphologic findings and previously reported data, it seems justified to postulate the presence of trophic innervation of melanocytes in the human iris.

Humans↗
PubMed1977

Electron-microscopic analysis of iris vessels in two cases of uveitis.

Electron-microscopic analysis of iris biopsy material was carried out paying particular attention to vessels and infiltrating cells. Characteristic changes of vessels and cells were found in two cases. One showed abundant lymphodiapedesis, perivascular infiltration, and vessels appearing morphologically normal. The other showed diffuse infiltration of cells and numerous fenestrated newly formed vessels. In the latter, three different types of opening in the endothelium were observed: (1) separation of intercellular junctions; (2) small pores or defects in the endothelium, and (3) large holes or defects in the endothelium. Cell leakage from normal and newly formed vessels was considered. We concluded that lymphocytes may migrate through the cytoplasm within membrane-bounded vesicles in normal vessels, whereas in newly formed fenestrated vessels cells, including small lymphocytes, may pass through three different types of opening in the endothelium.

Aged↗
PubMed1977

Histopathological study of canine optic nerve retina treated by organophosphate pesticide.

The fine structure of pathological changes was examined in the optic nerve and retina of beagle dogs after oral administration by capsule of the organophosphate pesticide ethylthiometon for 2 years. The optic nerve was invariably affected, and the number of myelinated axons markedly reduced. These were substituted for by delicate processes of astrocytes. Changes in the retina were mild and mainly seen in the peripapillary pigment epithelial cells and in the Müller cells of the peripheral retina. These histopathologic findings indicate that long-term administration of ethylthiometon involved both the optic nerce and selected portions of the retina.

Animals↗
PubMed1973

[Tensilon test].

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Edrophonium↗