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Biomedical subjects

K Morimoto

Publications and source records attributed to K Morimoto.

At least 757 records · Page 42Linked to original sources
PubMed1978

Chemical stability, alkylating activity, and lipophilicity of 1,1'-ethylene-bis(1-nitrosourea) and related compounds.

1,1'-Ethylene-bis(1-nitrosourea) (EBNU) posesses antitumor activity against leukemia L-1210. Chemical stability, alkylating activity, and lipophilicity of EBNU and related compounds were compared. EBNU was the most unstable among several bis-N-nitrosoureas and mono-N-nitrosoureas tested. The alkylating activity of EBNU was the same as that of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), but higher than those of other bis- and mono-N-nitrosoureas except 1-methyl-1-nitrosourea. Lipophilicity of EBNU was extremely low compared with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and CCNU.

Alkylation↗
PubMed1976

Uptake of bleomycin by human brain tumours.

The uptake of bleomycin (BLM) by various types of brain tumours after intravenous or intrathecal administration was investigated by bioassay in 67 patients. The correlation between the BLM distribution and the type and characteristics of brain tumours was studied.

Bleomycin↗
PubMed1976

Analysis of combined effects of benzene with radiation on chromosomes in cultured human leukocytes.

Three experiments were carried out on 53-hr cultured human leukocytes on chromosome mutagenicity of benzene with particular reference to combined effects with gamma-radiation and inhibitory effect on rejoining of radiation-induced chromosome breaks. The results and their analyses were summarized as follows: 1) Benzene can induce mainly chromatid-type deletions, especially gaps, suggesting that the cells in their late S-G2 stage have a higher susceptibility to chromosome breakage by benzene. 2) The aberration tield of dicentrics and rings induced by 100 rads irradiation can significantly be enhanced by the treatment of benzene equal to or in excess of 0.2 mM. 3) Quantitative analyses using newly defined "Synergetic effect factor" revealed that combined cytogenetic effect of benzene with radiation could be synergetic exclusively in dicentrics and rings, being almost additive in the other types of aberration. 4) The experiment with dosage fractionation method showed that the more strongly benzene could inhibit the rejoining of radiation-induced chromosome breaks, the higher concentration it was treated at. Related iwth these results, possible inducps, and the repair and its inhibition of radiation-induced DNA-strand(s) breaks. Further studies for related effects by benzene are needed on protein synthesis, activities of repair enzymes and fine structure of chromosomes.

Benzene↗