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Biomedical subjects

K Mochida

Publications and source records attributed to K Mochida.

At least 91 records · Page 5Linked to original sources
PubMed1988

Naturally occurring subclinical Corynebacterium kutscheri infection in laboratory rats: strain and age related antibody response.

Naturally occurring subclinical Corynebacterium kutscheri infection was analyzed by antibody response related to the strain of rats. Wistar-Lewis, Wistar and Spraque-Dawley rats were high responders in seroconversion rates and antibody titers, while Brown Norway and Fischer rats were low responders. The antibody response was related to age also. Some young rats had maternal antibody to C. kutscheri, but antibody disappeared before 8 weeks of age. Rats were antibody-negative for several months thereafter and became antibody-positive after 6 months of age. The antibody response was highest at 8 to 9 months of age in subclinical C. kutscheri infection. This antibody response was very late, compared to the antibody response to Sendai virus and Mycoplasma infections.

Age Factors↗
PubMed1988

Reproductive toxicity of muroctasin.

The reproductive toxicity of the anomeric mixture of N2-[(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin), a new immunomodulator, was investigated in mice and rabbits after subcutaneous injection. Neither the male or female fertility nor the reproductive performance of the mice was affected by doses of up to 1 x 10(4) micrograms/kg. MDP-Lys(L18) elicited no evidence of teratogenicity when injected subcutaneous during the period of organogenesis to pregnant mice at doses of up to 3 x 10(4) micrograms/kg, or to pregnant rabbits at doses of up to 25 micrograms/kg. However, the female mice receiving 3 x 10(4) micrograms/kg showed induration and scabbing of the injection sites. Decrease of maternal body weight and food intake was seen in rabbits at doses of 5 and 25 micrograms/kg. Lacrimation, bloodshot eyes and swelling of eyelid were observed in does at a dose of 25 micrograms/kg. In perinatal and postnatal toxicity study in mice using doses of up to 2 x 10(4) micrograms/kg, a decrease in body weight of dams was seen at a dose of 2 x 10(4) micrograms/kg. Decrease in body weight of pups at birth was observed at a dose of 2 x 10(4) micrograms/kg.

Abnormalities, Drug-Induced↗
PubMed1987

Aminothiazolylglycyl derivatives of carbacephems. I. Synthesis and antibacterial activity of novel carbacephems with substituted aminothiazolyl groups.

A series of new carbacephem compounds which have substituted aminothiazolylglycyl side chain have been prepared starting from corresponding carbacephems with aminothiazolylmethoxyimino group. Among them, the compound having 3,4-dihydroxybenzoyl group showed very sharp activity against Pseudomonas aeruginosa. Moreover, the optical resolution of alpha carbon of aminothiazolylglycyl moiety was carried out through preparation of optically active side chain and the (S)-isomer (KT-4380) was found to be the most active against Pseudomonas sp. as well as other Gram-negative strains.

Anti-Bacterial Agents↗
PubMed1987

Aminothiazolylglycyl derivatives of carbacephem antibiotics. II. Synthesis and antibacterial activity of novel aminothiazolyl cephem compounds with hydroxypyridone moiety.

The synthesis and antimicrobial activity of novel carbacephem antibiotics which have amido moiety of (S)-aminothiazolylglycyl side chain are described. Among them, the compound having 5-hydroxy-4-pyridon-2-carboxyl group (KT-4697) showed exceptionally strong activity against Pseudomonas aeruginosa as well as Gram-negative bacteria. A cephalosporin with this acyl group namely KT-4788 with methylpyridiniumthiomethyl group at C-3 was found to be the most active against Gram-positive and Gram-negative strains including P. aeruginosa.

Catechol O-Methyltransferase↗
PubMed1986

Serological surveys of Corynebacterium kutscheri infection in mice and rats.

Serological surveys of mice and rats naturally infected with Corynebacterium kutscheri were performed by examining serum samples collected from breeder and laboratory colonies between 1981 and 1983. Among 756 mice from 73 conventional colonies, only 4 animals (0.5%) from 3 colonies (4.1%) developed C. kutscheri antibody of 1:40 to 1:2, 560 titers. Three of them suffered from abscess caused by the organism. Regarding a titer of 1:40 or higher as reliably positive, 87 (13.0%) of 669 conventional rats or 20 (32.8%) of 61 colonies were found to be infected with the organism. The antibodies were detected in both types of animals older than 6 months of age. No lesions caused by C. kutscheri were found in almost all the rats examined. Germ-free and SPF mice and rats were all negative for antibody at 1:5 serum dilution.

Animals↗
PubMed1986

Beryllium toxicity to human, monkey and dog cells in culture.

The toxicity of beryllium was evaluated using a mammalian cell culture system. As the ID50 (a fifty per cent inhibitory dose, to growth of cells after 72 h of incubation) values for HEL-R66, KB, Vero and MDCK cells to beryllium were 0.8 X 10(-3) mM, 1 X 10(-3) mM, 0.9 X 10(-3) mM and 1.2 X 10(-3) mM, respectively, there was no remarkable difference in the sensitivity for these cells to beryllium.

Animals↗
PubMed1986

Reproductive toxicity of ofloxacin.

The reproductive toxicity of (+/-)-9-fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de] [1,4]benzoxazine-6-carboxylic acid (ofloxacin, Tarivid), a new antibacterial agent, was investigated in rats and rabbits after oral administration. Neither the male or female fertility nor the reproductive performance of the rats was affected by doses of up to 360 mg/kg. Ofloxacin elicited no evidence of teratogenicity when administered orally during the period of organogenesis to pregnant rats at doses of up to 810 mg/kg, or to pregnant rabbits at doses of up to 160 mg/kg. However, the female rats receiving 810 mg/kg showed salivation, dirty hair coats, soft stools, and decreases of body weight and food intake. The fetuses in the higher dose groups exhibited decreased body weight and retardation of ossification, and those in the highest dose group showed increased mortality and skeletal variations (cervical ribs, shortened 13th ribs). Further investigation of the fetal skeleton revealed that the critical period of the occurrence of skeletal variations was on days 9 and 10 of gestation. The occurrence of cervical ribs and shortened 13th ribs was not an indicator of teratogenicity when ofloxacin was administered at doses of up to 1600 mg/kg during the critical period. Moreover, the shortening of the 13th ribs was the only type of retardation of ossification degree. Decreases of maternal body weight and food intake, and increased mortality of fetuses were observed in rabbits at a dose of 160 mg/kg. In a perinatal and postnatal toxicity study in rats using doses of up to 360 mg/kg, no adverse effects were observed.

Animals↗