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Biomedical subjects

K Mizukoshi

Publications and source records attributed to K Mizukoshi.

At least 91 records · Page 5Linked to original sources
PubMed1987

Clinical features of cisplatin vestibulotoxicity and hearing loss.

Patients treated with cisplatin were observed in an otoneurological study with special reference to cochlear and vestibular toxicity. Toxicity-related symptoms appeared to be almost all transient. As with leukopenia, hearing loss and dizziness often occurred after several weeks of administration. In the equilibrium examinations, some abnormal findings such as spontaneous nystagmus and positional nystagmus were seen. Caloric tests and body sway tests detected abnormal findings in the early stages of cisplatin-related vestibulotoxicity.

Adolescent↗
PubMed1986

An application of the microcomputer as a generator of target movements for the eye tracking test (ETT).

We have developed a new system to produce target movements for our particular purposes using a microcomputer and 9-bit digital-to-analog converter. A continuously changing sinusoidal wave was produced to examine the relationship between the frequencies of target movements and smooth pursuit. A random sinusoidal wave was produced to make clear the predictive function of smooth pursuit.

Computers↗
PubMed1986

Gain of slow-phase velocity of optokinetic nystagmus.

Although slow-phase velocity of optokinetic nystagmus (OKN) increases according to the increase of stimulus velocity, it is not obvious whether both are quite equal or not. In this study, gain of slow-phase velocity in OKN response to stimulation velocity was analyzed by two methods of stimulation, constant acceleration, and constant velocity stimulation. In our observation, the gain of slow-phase velocity was not equal to 1.0 even at low-speed stimulation. On the other hand, the number of nystagmus almost corresponded to the number of stimulation stripes passing through the center of an OK-drum up to high-speed stimulation. The results of this study indicate that pursuit eye movement of slow-phase OKN should not be quite equal to that of the eye tracking test, i.e. being required to continuously look at a moving spot.

Acceleration↗
PubMed1986

Equilibrium disorders and R-R intervals in ECG.

We have measured RR intervals on patients with equilibrium disorders to check the function of the autonomic nervous system. And we have obtained two parameters (coefficient of variation "CV%" (the static function of the autonomic nervous system] and "A-B" (the dynamic function of the autonomic nervous system). The dynamic function of the autonomic nervous system (A-B) further deteriorated in elderly patients with central nervous system disorders. We concluded that disorders in the dynamic function of the autonomic nervous system affected the autoregulation which caused the central nervous system disorders, especially in elderly patients.

Adult↗
PubMed1985

Hazard to endotracheal tubes by CO2 laser beam. Experimental report.

Ignition or combustion of the endotracheal tube during CO2 laser microlaryngo surgery may cause fatal lung disorders. We undertook an experiment on ignition and combustion of endotracheal tubes by CO2 laser beam and came to the following conclusions: (a) the silicon endotracheal tube was nonflammable; (b) the spiral endotracheal tube was also nonflammable; (c) a pulse wave was recommended and 3-second intervals were necessary; (d) four sheets of moist gauze were necessary to prevent cuff trouble, and (e) it was advisable to set the O2 concentration below 25% when using the silicon endotracheal tube.

Carbon Dioxide↗
PubMed1985

Quantitative measurement of smooth pursuit using a continuously changing sinusoidal wave in normal subjects.

In order to examine the frequency of a target wave and induced eye movements we designed and developed a new target wave (continuously changing sinusoidal wave). This target wave consisted of 20 sinusoidal waves from 0.1 to 2.0 Hz with 10 degrees amplitude (peak-to-peak amplitude is 20 degrees). Several parameters were calculated quantitatively with a microcomputer in normal subjects, and the following conclusions were obtained: The amplitude gain (peak-to-peak amplitude of eye movements/peak-to-peak amplitude of the target wave) and the retinal error velocity were appropriate parameters for representing the input and output of smooth pursuit. The limit of smooth pursuit was 1.2 Hz.

Adult↗
PubMed1985

Quantitative measurement of smooth pursuit using the continuously changing sinusoidal wave in neurological patients.

In a previous paper [Ohashi, Watanabe, Kobayashi, Mizukoshi: ORL 47: 49-56] we developed a new sinusoidal wave with 20 continuously changing sinusoidal waves from 0.1 to 2.0 Hz and reported that in normal subjects the limit of smooth pursuit was 1.2 Hz, retinal error velocity (REV) was the most reliable parameter as input of smooth pursuit and amplitude gain was the most reliable parameter as output. In the present paper, we analyzed smooth pursuit system by the same method and discussed the relation between input and output of smooth pursuit in patients with neurological disorders. Our results indicated that the relationship between input and output of the smooth pursuit was particularly abnormal in patients with cerebellar disorders.

Brain Diseases↗
PubMed1984

Quantitative analysis of the visual vestibulo-ocular reflex using sinusoidal rotation in patients with peripheral vestibular disorders.

In order to investigate interaction of the vestibular and optokinetic systems in patients with peripheral vestibular disorders, the visual vestibulo-ocular reflex (V-VOR) gain in 49 patients with peripheral vestibular disorders was quantitatively measured by using pendular harmonic sinusoidal rotation with optokinetic stationary stimuli. The patients were rotated sinusoidally both with eyes closed and open at an amplitude of 240 degrees and at a frequency of 0.1 Hz (peak velocity 75.4%s). Comparing the vestibulo-ocular reflex (VOR) and V-VOR gains in the patients with definite Meniere's disease (23 cases), benign paroxysmal positional vertigo (BPPV, 13 cases) and sudden deafness with vertigo or dizziness (13 cases), the VOR-DP and normal V-VOR gain were more frequently observed in patients with Meniere's disease (13 cases) and sudden deafness (7 cases) than in those with the BPPV (3 cases). In the four patients with bilateral Meniere's disease and sudden deafness, abnormally decreased VOR-gain (under 0.55) in the bilateral directions with slightly decreased V-VOR gain was measured when tested independently. However, abnormal V-VOR gain was observed in only one case of sudden deafness due to retrocochlear lesions. From our VOR and V-VOR gain observations comparing the caloric responses, we have concluded that the comparison of VOR with V-VOR gains provides additional information for evaluation of peripheral vestibular disorders as well as central nervous system disorders.

Computers↗
PubMed1983

Quantitative analysis of the human visual vestibulo-ocular reflex in sinusoidal rotation.

In order to investigate interaction of the vestibular and optokinetic system, a visual vestibulo-ocular reflex (V-VOR) gain in forty-five normal subjects was measured by manual and computer analysis. The test subjects sat in a newly devised, pendular rotating chair in an optokinetic drum. With this device pendular harmonic sinusoidal rotation and optokinetic stimuli could be given simultaneously. The test subjects were rotated sinusoidally at amplitudes of 120 degrees and 240 degrees and at frequencies of 0.05 Hz and 0.1 Hz (maximum velocities 18.8 degrees/s, 37.7 degrees/s, 75.4 degrees/s), and with eyes closed and open. Within these pendular stimuli, there was no response decline phenomenon nor influence of amplitude on frequency. The pure VOR gain measured in dark room with eyes open was about 0.6 and did not vary with the eyes closed as long as mental alertness was maintained. The V-VOR gain in a stationary optokinetic drum with eyes open was about 1.1. From our observations, the 0.1 Hz sinusoidal rotation with an amplitude of 240 degrees (maximum velocity, 75.4 degrees/s) is an appropriate stimulation for the V-VOR and VOR test battery in clinical practice.

Adolescent↗