Search PubMed⌕ Search

Biomedical subjects

K Mizoi

Publications and source records attributed to K Mizoi.

131 records · Page 8Linked to original sources
PubMedDate not supplied

Germ cell tumors of the central nervous system originating from non-pineal regions: CT and MR features.

CT and MR findings were retrospectively reviewed in 12 patients with germ cell tumors originating from the non-pineal regions. Cystic or necrotic components were seen in 6 patients. Of 4 germinomas, 2 showed mixed density on the CT. The MR signal intensity of the tumor was non-specific. Of 8 germinomas, 4 were inhomogeneously enhanced on postcontrast CT and T1-weighted MR images. CT and MR features of germinomas originating from non-pineal regions frequently differ from those of germinomas originating from the pineal region. The mass of the tumor often appeared cystic and inhomogeneously enhanced following contrast infusion.

Adolescent↗
PubMedDate not supplied

The protective effect of combined administration of anti-oxidants and perfluorochemicals on cerebral ischemia.

We previously published results of investigations which indicated that the combination of mannitol, which acts as a free radical scavenger, and perfluorochemicals (PFC), which have a strong oxygen-carrying capacity, can be therapeutic in cases of brain infarction. The present experiment tested the hypothesis that the effectiveness of such treatment could be increased by an optimal combination of such scavengers and other chemicals. Fifty-two dogs were used, employing the "canine model of a completely ischemic brain regulated with the perfusion method." A total of six drugs with free radical scavenger capacities were tested: mannitol, vitamin E, vitamin C, Nizofenone (Y-9197), dexamethasone (DEXA) and suloctidil (MY-103). These drugs were administered intravenously 15 minutes prior to the production of ischemia, when cerebral blood flow was reduced to one-tenth its normal volume. After one hour, recirculation was allowed and the recovery of electrical activity of the brain observed for three hours. Judged by the degree of recovery of brain electrical activity, five drugs were considered to have protective effect against brain ischemia: mannitol, vitamin E, MY-103, DEXA and Y-9197. Among these five drugs, mannitol, vitamin E and DEXA are known to be safe and easily used clinically. The combined administration of these three drugs, together with PFC, was also investigated. It was found that the speed and degree of recovery of brain electrical activity were greater when these drugs were given together than when one was administered alone.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Clinical results of hearing aid with noise-level-controlled selective amplification.

We have developed a hearing aid which reduces the low-frequency energy of the input sound according to the input noise level and the spectrum of the environmental noise. The results of speech discrimination tests using speech in noise in 70 hearing-impaired subjects showed improvement in word discrimination scores in noise of over 15% for 50 of 53 subjects with sensorineural hearing loss. This group of hearing-impaired patients was subdivided into categories according to (a) audiogram type [flat, sloping (i.e. gradual high-frequency loss) and abruptly falling (steep high-frequency slope)]; (b) degree of hearing loss (less than or more than 50 dB average loss) and (c) etiology (familial deafness, presbyacusis). Results on 17 subjects with conductive or mixed hearing impairments showed no improvement, but expressed a preference for this system. The subject reported that the sound was more natural and quiet compared with the conventional AGC hearing aids.

Adolescent↗