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Biomedical subjects

K Miyake

Publications and source records attributed to K Miyake.

At least 703 records · Page 39Linked to original sources
PubMed1977

Prevention of cystoid macular edema after lens extraction by topical indomethacin (I). A preliminary report.

Topically administered indomethacin was found to reduce the occurrence of cystoid macular edema after lens extraction. Indomethacin was given topically as 1% oil solution (sesame oil) eye drops twice or three times daily from the day before operation to the 40th day after operation. This effect suggests that prostaglandins play a leading role in the development of this disorder. It is postulated that operative irritation causes production of prostaglandins, which disrupt the blood-aqueous barrier, followed by an increase of the inflammatory mediators and debris in the aqueous. These inflammatory substances and prostaglandins themselves diffuse from the aqueous into the posterior pole of the fundus, where they induce inflammatory changes in vascular permeability in the perifoveolar capillary plexus. Clinically the cystoid macular edema then develops.

Administration, Topical↗
PubMed1976

[Chronological changes in leukemias in Hokkaido (author's transl)].

The various leukemias in Hokkaido for the past 20 years are analysed in its change of the mortality rate, the type of leukemia, and the clinical picture. The observation years are divided into 4 periods: I (1951-1957), II (1958-1962), III (1963-1967), IV (1968-1972). 1. The adjusted mortality rate of leukemia shows a rising tendency through these periods: I (1.7), II (3.0), III (3.5), IV (3.6). 2. The adjusted age-specific mortality rate of leukemia in period II, III, and IV, show a remarkable increase in all age brackets compared with period I, especially in older age brackets. The rate of the "60-69 years old" bracket gradually rises as I (3.1), II (4.8), III (5.9), IV (7.2). The rate of the "over 70 years old" bracket is I (1.3), II (1.8), III (5.0), IV (9.3). It is characteristic that these brackets has the highest mortality rate in period IV. 3. Some comparisons between period I and IV are described as follows: (1). Monocytic leukemia had decreased from 10.6% (I) to 1.4% (IV) and chronic myelogenous leukemia has slightly increased in period IV. (2). In acute type, the cases of aleukemic leukemia tends to increase in period IV and its initial symptoms changes into mild gradually. (3). In chronic type in period IV, splenomagaly is common in the initial symptom and while blood cell counts in these cases are above 10 x 10(4)/cmm.

Acute Disease↗
PubMed1975

Purification of Japanese encephalitis virus vaccine by zonal centrifugation.

A large-scale procedure for purification and concentration of Japanese encephalitis virus vaccine by a continuous-flow isopycnic banding technique in a sucrose density gradient solution, using a K-III zonal centrifuge rotor, is presented. The quality of zonal-purified vaccine was compared with commercial and Japanese National Institutes of Health reference vaccines for antigenicity, immunodiffusion, and allergic encephalitogenicity tests to show its high purity.

Animals↗