Search for sequential heavy leptons in e+e- collisions at the energy sqrt s =52 GeV.
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Journal Article↗
Biomedical subjects
K Miyake
Publications and source records attributed to K Miyake.
New measurement of the asymmetry parameter for the Sigma +-->p gamma decay.
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Journal Article↗
Punch for removal of anterior lens capsule.
A punch was developed for excision of the anterior lens capsule, performed primarily in conjunction with so-called endocapsular procedures. The punch allows uniform anterior capsulectomy without any significant damage to the zonule. The punch is particularly useful for eyes with weak or scarred lens capsules, which are difficult to manipulate with conventional tools for anterior capsulectomy.
Humans↗
Long-term effects of topically applied epinephrine on the blood-ocular barrier in humans.
Epinephrine (1.25%) was applied topically twice daily to both eyes of 22 patients with glaucoma or ocular hypertension. Half of these patients received topical indomethacin (0.5%) three times daily in one eye; the other half received indomethacin placebo under the same regimen. Blood-aqueous and blood-retinal barrier functions were determined by aqueous and vitreous fluorophotometry before and 1, 2, 3, and 7 months after initiation of treatment. Epinephrine-induced disruption of the blood-aqueous barrier, noted at two months, apparently remained constant until the completion of the study. At months 2, 3, and 7, indomethacin significantly inhibited this disruption. The blood-retinal barrier was unaffected. These results bear on the hypotensive mechanism of topically applied epinephrine.
Administration, Topical↗
Elastic fibers in tunica propria of undescended and contralateral scrotal testes from cryptorchid patients.
Elastic fibers in the tunica propria of the testes from cryptorchid patients and normal fertile adults were examined by light (Weigert resorcin-fuchsin stain) and electron microscopic techniques. In the testes from normal fertile adults, elastic fibers were proved to exist in the tunica propria by light and electron microscopy, and were located in the fibrous and cellular layers of the tunica propria. In the undescended testes from the cryptorchid patients, during prepubertal and pubertal periods, elastic fibers could not be visualized in the tunica propria, but were found after puberty. The positive Weigert reaction of the tunica propria in the undescended testes from postpubertal cryptorchid patients, however, was markedly weaker than that in normal control patients, suggesting diminution of elastic fibers. This diminution of elastic fibers in the undescended testes from postpubertal cryptorchid patients was also substantiated by electron microscopy. However, in the contralateral scrotal testes, elastic fibers appeared during puberty and were observed after puberty in the same manner as in normal testes. Thus, the present study suggested retarded appearance of elastic fibers in puberty and impaired development of those fibers after puberty, in the undescended testes of cryptorchid patients.
Adolescent↗
Response of the isolated human seminiferous tubule to prostaglandins F1 alpha, F2 alpha, E1 and E2.
In an attempt to ascertain whether prostaglandins alter the in vitro contractile activity of the human seminiferous tubule, the effects of prostaglandins on the isolated human seminiferous tubule were examined by recording the intratubular pressure with a servonull pressure with a servonull pressure measuring device. We describe here the first response of the human seminiferous tubule to prostaglandins. Prostaglandin F2 alpha (10(-9) M to 10(-6) M) produced contractions of the seminiferous tubules in a dose-dependent manner. In contrast, prostaglandins F1 alpha (10(-8) M to 10(-6) M), E1 (10(-9) M to 10(-6) M) and E2 (10(-8) M to 10(-6) M) produced relaxations of the seminiferous tubules which were dose dependent. The results from these experiments suggest that prostaglandins modulate the in vitro contractility of the human seminiferous tubules and thus may regulate the transport of spermatozoa and tubular fluid to the rete testis.
Adult↗
Parathyroid adenoma imaged by gallium-67 citrate. A case report.
A parathyroid adenoma imaged by Ga-67 citrate in a 17-year-old man with primary hyperparathyroidism and a palpable solid tumor in the neck is presented. Although preoperative examination and intraoperative findings suggested a parathyroid carcinoma, histologic studies showed a parathyroid adenoma with predominant chief cell type.
Adenoma↗
The origin of antibody-forming cells detected in the bone marrow after thymus-independent antigen-stimulation and abnormality in migration of B cells of X-linked immunodeficient CBA/N mice.
The anti-TNP IgM plaque-forming cells (PFC) were generated in the spleen and bone marrow of non-immunodeficient normal mice after intraperitoneal administration of TNP-LPS. Irradiation of normal mice while shielding bone marrow completely abrogated the generation of bone marrow PFC, indicating that they are derived from extramedullary sites. The bone marrow PFC, response to TNP-LPS was low in X-linked immunodeficient CBA/N strain mice, while the spleen response was comparable to that seen in the normal mice. To further study the basis of the deficient bone marrow PFC response in CBA/N mice, spleen cells were adoptively transferred to irradiated syngeneic mice stimulated with TNP-LPS. While spleen cells from normal mice generated high numbers of PFC in recipient bone marrow and spleen, those from CBA/N strain mice could not generate bone marrow PFC. This result was obtained regardless of whether normal or CBA/N recipients were used. These results indicate that TNP-LPS administration normally results in the migration of B lymphocytes from the periphery into the bone marrow and that B cells from immunodeficient CBA/N strain mice bear an inherent defect in this migratory function. This migratory defect was shown to be X-linked, as are the other previously reported B cell defects in this inbred mouse strain. The possible relationship between this migratory defect and the maturational defects of B cell lineage as reported previously in CBA/N strain mice is discussed.
Animals↗
Evidence for innervation of the myoid cell in the human seminiferous tubule.
Although the existence of the seminiferous tubule contractions attributed to myoid cells is established, the control of the contractions is poorly understood. Recently, we have suggested the possible neural control mechanism for contractility of the human seminiferous tubule. In an effort to identify the nerve supply to the myoid cells in the human seminiferous tubules, we studied the paraffin sections of biopsied testicular specimens using a protein silver impregnation technique (Bodian's method). Here we demonstrate evidence for the presence of nerve fibers close to the myoid cells. It is highly suggested that contraction of the human seminiferous tubule may play an important role in the transport of spermatozoa, and neurohumoral regulatory mechanism may partly exist in this connection.
Adult↗
Overall morphology of basement membrane of rat seminiferous tubule as revealed by scanning electron microscopy.
Scanning electron microscopic observation of the basal surface of the basement membrane of the rat seminiferous tubule has revealed that the basement membrane appears to be like a tiled floor, and formation of meshwork structure of collagen fibrils is evident in some exfoliated areas of basement membrane. This meshwork structure is considered to ensure fluid regulation from the intertubular medium toward the lumen of the seminiferous tubules.
Animals↗
[Treatment of advanced testicular cancer].
Two patients with stage II, 12 patients with stage III advanced testicular cancer, were treated with a combination of CDDP, vinblastine and bleomycin. Four of the cases (28.6%) achieved a complete response and 6 (42.9%) achieved a partial response. The over all response rate was 71.4%. After CR, 2 cases (50%) showed relapse. Although the treatment confirms some efficacy of the drug regimen, the prognosis is poor in bulky metastasis. Early induction therapy with etoposide is necessary in cases of high volume metastasis.
Adult↗
A study of cryptorchidism. III: The histochemistry of complex carbohydrates in the testes of cryptorchid patients.
The complex carbohydrates in the undescended and contralateral scrotal testes of patients with cryptorchidism, were examined by light microscopic histochemical methods, in comparison with those of normal testes. In the undescended testes, histochemical reactions for acidic and neutral complex carbohydrates were apparently weaker than in the normal testes, especially pronounced in the seminiferous tubular walls. In the germinal and supporting cells of the undescended testes, the amount of galactose residues in the complex carbohydrates decreased from the prepubertal to post-pubertal periods. Periodic acid-Schiff reaction also revealed a decrease in the glycogen content in the germinal and supporting cells of the undescended testes from pre-pubertal to post-pubertal periods.
Adolescent↗
[Performance of tumor markers on the ES-600 system (B.M.) in routine use].
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Biomarkers, Tumor↗
[Recurrence of transitional cell carcinoma in the left pelvis and ureter, and ileal conduit after total cystectomy: a case report].
A 63-year-old male with transitional cell carcinoma of the bladder underwent total cystectomy. Five years later sequential excretory urography and urinary cytologic examination revealed tumor recurrence in the left pelvis and ureter; left nephroureterectomy was performed in July, 1984. In December, 1985, he complained of macrohematuria and urinary cytology was positive. Ileal conduitgraphy showed filling defects at the bilateral uretero-ileal anastomosis, where two papillary lesions were disclosed by endoscopic examination. In January, 1986, total extirpation of the ileal conduit and reconstruction of a new ileal conduit was performed. Macroscopically the two lesions were found to be a papillary tumor at left uretero-ileal anastomosis and a polypoid tumor distal to right uretero-ileal anastomosis. Histological examination revealed both tumors to be grade II transitional cell carcinoma. This rare case is discussed and the literature is reviewed.
Anastomosis, Surgical↗
[A case of congenital unilateral multicystic kidney with renal matrix calculi].
A forty-two-year-old man was seen with right lumbar pain. Physical examination revealed a right flank mass. Conventional excretory urography showed lack of right renal function, whereas left kidney was visualized. Right nephrectomy was performed. A cluster of several different sized cysts was disclosed in the right renal region. The renal surface was smooth. The removed kidney weighed 1,150 g. The ureter was completely obstructed at the ureteropelvic junction. Cysts were filled with matrix calculi. Pathological examination showed dysplastic glomeruli and primitive tubules within loose embryonic mesenchyme between two cysts whose walls consisted of smooth muscle strands and connective tissue. The final diagnosis was a congenital unilateral multicystic kidney with renal matrix calculi. The multicystic kidney is the most common form of renal cystic disease in infancy. However, few cases in adults have been reported. The diagnostic approach, treatment and outcome of a congenital unilateral multicystic kidney are discussed.
Adult↗
Comparison of enoxacin and norfloxacin in patients with cystitis.
The urinary antibacterial drugs enoxacin and norfloxacin were compared for efficacy and side effects in the treatment of lower urinary tract infections. Thirty-five patients received enoxacin and 25 received norfloxacin for one week. The antibacterial spectrum of enoxacin was noted to be better than that of norfloxacin, but both drugs performed well in clearing the infections caused by susceptible organisms. The incidence of side effects was higher with norfloxacin than with enoxacin.
Adolescent↗
Pre- and postoperative therapy in cataract extraction.
This review is an update on the subjects directly or indirectly concerning pre- and postoperative therapy in cataract extraction. Topics were selected from those which the authors thought to be significant mainly from the clinical point of view. The review covers antiprostaglandins therapy, intraocular lens, Nd-YAG laser and others. The authors briefly summarize the latest trends in the above topics and give critical comments.
Cataract Extraction↗
Indomethacin and the epinephrine-induced breakdown of the blood-ocular barrier in rabbits.
Using aqueous and vitreous fluorophotometry, the authors examined the blood-aqueous and blood-retinal barrier functions in three groups of pigmented rabbits. Epinephrine (1.25%) was applied topically five times daily and indomethacin (0.5% sesame oil suspension) was applied topically three times daily to one eye of each of the animals in Group 1; under the same regimen, epinephrine and indomethacin placebo were administered to one eye of each of the animals in Group 2 and epinephrine placebo and indomethacin placebo were administered to one eye of each of the animals in Group 3. Fluorophotometry was done 1, 2, and 3 months after drug administration. The results showed that epinephrine induced disruption of the blood-aqueous barrier 2 and 3 months after drug administration, and that the magnitude of this disruption increased with time. Epinephrine also induced disruption of the blood-retinal barrier 3 months after drug administration. Indomethacin significantly prevented disruption of the blood-aqueous barrier at 2 and 3 months and significantly prevented disruption of the blood-retinal barrier at 3 months. The magnitudes of the barrier disruptions in eyes treated with both epinephrine and indomethacin were slightly higher than, or the same as, those of the control eyes. The results strongly indicated that the epinephrine-induced disruption of the blood-ocular barrier was partially caused by prostaglandins and other cyclo-oxygenase products whose biosynthesis was initiated by epinephrine.
Animals↗