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Biomedical subjects

K Misugi

Publications and source records attributed to K Misugi.

At least 55 records · Page 3Linked to original sources
PubMed1988

A case of renal angiomyolipomas associated with multiple and various hamartomatous microlesions.

A case of 50-year-old woman who demonstrated large intrarenal and externally protruding angiomyolipomas (AMLomas), unusual intraglomerular lesions and multiple hamartomatous microlesions of various types within the kidney is reported. This type of intraglomerular lesion has been briefly described only twice previously in patients with tuberous sclerosis (TS), and is unique in its location and histological appearance. The lesions are mainly composed of proliferating mesangial cells and are hamartomatous in nature. Although no stigmata of TS other than renal AMLomas are apparent in this case, the presence of many renal hamartomatous lesions suggests the possibility of a forme fruste of TS.

Female↗
PubMed1988

An ovarian Sertoli-Leydig cell tumor with heterologous mucinous gland and NSE-immunoreactive-cell.

A rare case of ovarian Sertoli-Leydig cell tumor with heterologous mucinous glands and tiny carcinoid-like foci in a 33-year-old female is reported. In addition to these heterologous elements, peculiar cells, which were oval, eosinophilic and neuron-specific enolase (NSE)-positive, were also observed and had not been described previously. These NSE-immuno-reactive cells were different from argentaffin cells observed in mucinous glands and carcinoid-like foci, and seemed to play a significant role in the appearance of the heterologous mucinous gland. The nature of this peculiar NSE-immunoreactive cell is discussed.

Adult↗
PubMed1988

Three categories of the degenerative appearance of the human cerebellar dentate nucleus. A morphometric and morphological study.

This morphometric and morphological study demonstrates 3 categories (types A, B and C) of degenerative feature in the cerebellar dentate nucleus. Type A is characterized by neuronal loss, astrocytosis and granular and/or amorphous argyrophilic change around the neurons and neuronal processes, and this type was thought to be synonymous with the so-called grumose degeneration of the DN. Type B is characterized by extensive neuronal loss and astrocytosis without argyrophilic change, and it was considered that many diverse factors were responsible for type B. Type C features marked swelling of the neurons without neuronal loss, astrocytosis or argyrophilic change. The Purkinje cells were not involved in type A and C, but severely damaged in type B. Clinically, type A was observed in progressive supranuclear palsy and dentatorubropallidoluysian atrophy, type B extensively in many diseases including anoxic, toxic and infectious disorders, and type C in tardive dyskinesia manifesting with oral hyperkinesia. Types A and C may be more or less specific signs of degeneration of the dentate nucleus, whereas type B appears to be non-specific.

Adult↗
PubMed1988

Pulmonary hypertension associated with portal hypertension in childhood. Case report of a 6-year-old child and review of the literature.

Pulmonary hypertension is a rare complication of portal hypertension. Reports of childhood cases especially rare. This report describes an autopsy case of a 6-year-old boy with congenital biliary atresia followed by liver cirrhosis in whom severe hypertensive pulmonary arterial changes, including medial hypertrophy, intimal fibrosis and plexiform lesions were demonstrated. Fresh and organizing fibrin-platelet thrombi as well as probable organized thrombi with recanalization were occasionally found in the pulmonary vasculature, but it was thought that they had probably been formed locally as a late complication rather than being of thromboembolic origin. Retrospectively, the chest roentgenograms had revealed abnormalities suggestive of pulmonary hypertension since infancy, but the patient showed no apparent symptoms of it during life. Previously reported childhood cases of pulmonary hypertension associated with portal hypertension were briefly reviewed. Although the mechanism is presently not known, it is suggested that patients with portal hypertension, even in early childhood, are at risk of developing this unusual complication.

Biliary Atresia↗
PubMed1987

Tardive dyskinesia with inflated neurons of the cerebellar dentate nucleus. Case reports and morphometric study.

Four autopsied cases of tardive dyskinesia manifesting oral hyperkinesia revealed markedly inflated neurons in the cerebellar dentate nucleus (DN), which had not been described previously. The inflation of the neurons was proved to be statistically significant (P less than 0.01) by morphometric study. The nuclei were usually situated in the central portion of the cytoplasm. This inflated change was different from both central chromatolysis and grumose degeneration of the DN, typically observed in progressive supranuclear palsy and dentatorubropallidolysian atrophy, and seemed to be easy to miss without careful observation, since neuronal loss and gliosis were very mild in the DN. Among a few autopsied cases of tardive dyskinesia reported previously, degeneration of the DN was described in only two. It is believed, however, that the inflated neurons of the DN may not be so rare and may be related to the occurrence of some involuntary hyperkinesia, especially oral hyperkinesia following some neurotoxic disorders and/or neuroleptic medications.

Aged↗
PubMed1987

Induction of suppressor T cells by intravenous administration of monoclonal anti-I-A antibody.

Intravenously administered monoclonal anti-I-A antibodies successfully induced suppressor T (Ts) cells specific for alloantigen-specific delayed-type hypersensitivity (DTH) responses in mice. These Ts cells exerted their effects in the effector phase and had no H-2 restrictions. Phenotypic analysis revealed L3T4 antigens on their cell surface but failed to reveal Lyt-2 antigen. Ts cell activity was abrogated by a 30-min incubation with the anti-I-A antibodies used for Ts cell induction. Incubation in the anti-I-A-antibody-coated plate also abrogated the Ts cell activity. Since anti-I-A antibody is idiotypic for the I-A antigen, it is suggested that these Ts cells might express antiidiotypic receptors for I-A antigens. These findings are considered to be consistent with previous observations of hapten-specific systems, in which antiidiotypic Ts cells are inducible by idiotypic antibodies.

Animals↗
PubMed1987

Immunohistochemical study of pancreatoblastoma.

Three cases of pancreatoblastoma in children were examined immunohistochemically and the results were compared with those of pancreatic duct carcinoma in adults. The pancreatoblastoma demonstrated positive reactions to alpha-fetoprotein (AFP) (67%: 2/3), alpha-1-antitrypsin (AAT) (100%: 3/3), carcinoembryonic antigen (CEA) (67%: 2/3) and keratin (33%: 1/3), although CEA was only weakly positive in both cases. On the other hand, adult pancreatic duct carcinoma showed positive reactions as follows; AFP: 3% (1/29), AAT: 21% (6/29), CEA: 97% (28/29) and keratin: 93% (27/29). Also, endocrine substances including insulin, glucagon and somatostatin were all negative in the pancreatoblastomas. Two cases of pancreatoblastoma which were immunohistochemically positive for AFP also showed elevation of the serum AFP level clinically. The different expressive pattern of oncofetal antigens in pancreatoblastoma as compared with pancreatic duct carcinoma in adults may provide further supporting evidence for the embryonic nature of pancreatoblastoma, and suggests that such a pattern might be used as a tumor marker for pancreatoblastoma.

Adult↗
PubMed1987

Ras p21 expression in nephroblastoma group tumors.

Ras p21 expression in 30 cases of nephroblastoma and related tumors was evaluated by the immunoperoxidase method using monoclonal anti-ras p21 antibody (RAP-5) raised against a synthetic polypeptide fragment of ras p21. In normal renal tissue, the epithelial cells of convoluted and collecting tubules and arterial wall leiomyocytes were positively stained. In nephroblastoma tumors, some of the epithelial cells forming primitive tubular and glomerular-like structures in the nephroblastic-type tumors and the cells with rhabdomyocytic features were positive. However, the epithelial cells in more differentiated glandular structures of epithelial-type tumors, the rhabdoid cells in rhabdoid tumors and the cells in congenital mesoblastic nephroma failed to show positive staining. Nephroblastic cells, stromal cells and sarcomatous cells were also negative.

Antibodies, Monoclonal↗
PubMed1987

Analysis of alloantigen-specific suppressor T cells.

The intravenous administration of allogeneic spleen cells successfully induced two distinct subsets of alloantigen-specific suppressor T cells that function at either the induction phase or the effector phase of alloantigen-specific DTH responses. The induction phase suppressor T cells were found to be Lyt2-, and were not genetically restricted by H-2 region genes. The effector phase suppressor T cells are Lyt2+, and their activity is controlled by genes within the H-2 region. The effector phase suppressor T cells mediate antigen-dependent bystander suppression, provided the appropriate alloantigen is present at the site of the immune responses. This effector phase suppression requires cyclophosphamide-sensitive targets. The results of this study suggest that allospecific suppressor T cells and hapten-specific suppressor T cells have a similar mechanism of action.

Animals↗
PubMed1987

Appendiceal endometriosis in pregnancy. Report of a case with perforation and review of the literature.

A 25-year old woman at the 26th week of gestation underwent surgery for possible acute appendicitis. Pathological examination of the appendix showed extensive decidual change through the entire wall with perforation and surrounding acute inflammatory cell infiltration. To our knowledge, the present report is the second case of appendiceal endometriosis with this rare complication in the literature. The previously reported cases of appendiceal endometriosis which manifested clinically during pregnancy are briefly reviewed.

Adult↗
PubMed1986

"Black thyroid" associated with minocycline therapy. A report of an autopsy case and review of the literature.

An autopsy case of a 69-year-old woman showing black discoloration of the thyroid gland designated as "Black thyroid" was reported. The patient received long-term, high dose antibiotics minocycline therapy (total dose: 70 g) for bronchial asthma associated with respiratory infection and died of uterine cancer. The thyroid gland was coal black in color and histological examination revealed numerous dark brown pigments scattered in the follicular epithelium and colloid matrix. Special stains and electron microscopic examination suggested these deposited pigments to be consistent with lipofuscin. Histological examination of the thyroid glands in consecutive 500 autopsy cases revealed intimate relationship between deposition of lipofuscin pigments in the follicular epithelium and age of the patients. But, massive deposition of lipofuscin in the thyroid alone did not make the thyroid black and addition of minocycline appeared to be necessary for the black discoloration.

Aged↗
PubMed1986

Undifferentiated renal cell carcinoma in infancy: report of a case and review of literature.

A case of rapidly progressed undifferentiated renal cell carcinoma in a 2 2/12-month-old boy is reported. The histology is characterized by sarcomalike spindle and pleomorphic cells and bizarre giant cells, thus creating many difficulties in the differential diagnosis. The diagnosis of renal cell carcinoma was established on the basis of tubular formation by clear and granular cells observed in a few discrete areas. The literature on renal cell carcinoma occurring under 10 years of age was reviewed, with special attention given to histological typing. It is generally believed that renal cell carcinoma in children is well differentiated, but 2 of 39 cases reviewed were undifferentiated. We conclude that renal cell carcinoma in infants or young children may have an undifferentiated, atypical histological appearance and can progress rapidly. The differential diagnosis from anaplastic Wilms' tumor and sarcomatous tumors of the kidney in children is discussed.

Autopsy↗
PubMed1986

Idiopathic right ventricular dilation. Special reference to "arrhythmogenic right ventricular dysplasia" and analogous lesions.

Two autopsy cases which showed marked depletion of the right ventricular musculature of the heart accompanied with marked infiltration of the adipose tissue were reported. The first cases was an 18-year-old female who died of right sided congestive heart failure after about 4-years clinical course. The autopsy disclosed marked dilation of the right atrium and ventricle. The entire free wall of the right ventricle was markedly thin. Microscopically, most of the myocardial fibers of the right ventricle were replaced by fat and fibrous tissue. The second case, a 15-year-old boy, whose identical twin was previously diagnosed as arrhythmogenic right ventricular dysplasia designated by Fontaine et al., died suddenly during exercise. He showed no cardiac symptoms but electrocardiogram was abnormal. Autopsy revealed majority of the myocardial fibers of the right ventricular free wall were replaced by fatty tissue. In both cases, fatty infiltration was mainly noticed at the epicardial side and some myocardial fibers remained in the fatty tissue showed hypertrophic and/or degenerative changes. Review of the literature on similar cases showing depletion of the right ventricular musculature including so-called adult's Uhl anomaly, ARVD and dilated right ventricular myocardiopathy was conducted and the relationship of the present cases with these lesions was discussed.

Adipose Tissue↗
PubMed1985

Immunohistochemical and ultrastructural study of early lesions of intravascular bronchioloalveolar tumor with liver involvement.

Autopsy findings including immunohistochemical and ultrastructural study of intravascular bronchioloalveolar tumors (IVBAT) of the lung and liver which were incidentally found in a 68-year-old man were reported. The tumors presented as several, small nodular lesions in bilateral lungs and liver. Immunohistochemical study using the antibody against Factor VIII-related antigen and electron microscopic study suggested endothelial nature of both pulmonary and hepatic lesions. The study by using anti-estradiol antibody revealed the presence of estrogen in the cytoplasm of neoplastic cells, suggesting the possibility of the presence of estrogen receptors in the cells. Although the result is still preliminary, some role of estrogen in the development of IVBAT is suggested. The hepatic lesions have been thought to be metastases from the pulmonary IVBAT but the other possibilities such as primary hepatic or multicentric origin must be considered. Review of the previous reports of IVBAT disclosed several cases which were associated with liver involvement.

Aged↗