Ebstein disease in a newborn.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to K Misra.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
In the present study curcumin bioconjugates, viz. di-O-glycinoylcurcumin (I), di-O-glycinoyl-C(4)-glycylcurcumin (II), 5'-deoxy-5'-curcuminylthymidine (5'-cur-T) (IV), and 2'-deoxy-2'-curcuminyluridine (2'-cur-U) (V) have been synthesized and characterized by elemental analysis and (1)H NMR. The turmeric peptide (Tp) was isolated from the aqueous turmeric extract of the turmeric rhizome. The antibacterial activity of these four bioconjugates and also of the turmeric peptide and sodium salt of curcumin (III) have been tested particularly for beta-lactamase-producing microorganisms.
OBJECTIVE: To conceptualize, with fine needle aspiration cytology (FNAC), the early cellular events occurring in and around fresh autogenous and allogenic bone grafts during the first 40 postimplantation days. STUDY DESIGN: Forty-eight cases of bone grafts were studied by FNAC at serial intervals of 10, 20, 30 and 40 postimplantation days. Twenty patients were recipients of autogenous grafts, 16 received 0.6N HCI partially decalcified allogenic bone implants, and 4 received combined autogenous and allogenic bone grafts (included in the allograft group). There were eight control cases of closed fracture shaft femur, which were managed conservatively. RESULTS: The initial cellular responses in autogenous grafts, allografts and controls appear to be a part of the nonspecific reparative process followed by a more specific phase, with a steady increase in relative lymphocyte count from the 20th day onwards. Osteogenesis, as judged by osteoblasts and osteoclasts, was also comparable. CONCLUSION: Partially decalcified allografts appear to be a good substitute for autogenous bone grafts in clinical practice when adequate autogenous material is not available. FNAC is a good technique for studying bone graft responses without interfering with graft uptake. It is helpful in the early detection of subclinical infection or any other pathology at the graft site.
A tumor located subcutaneously over the coccyx of a 32-year-old woman was diagnosed by fine needle aspiration (FNA) cytology as a myxopapillary ependymoma originating in the soft tissue. The FNA smears showed characteristic papillary structures, consisting of a central mucinous core surrounded by cuboidal-to-columnar cells, and scattered ependymal cells. The excised tumor was connected to neither the filum terminale nor the cauda equina. Histopathologic study confirmed the cytologic findings.
A lipoblastoma, an uncommon tumor of childhood that can be mistaken for a liposarcoma, was preoperatively diagnosed by fine needle aspiration cytology. The characteristic features on the cytologic smears were the presence of immature fat cells in the form of spindle-shaped cells, stellate cells and vacuolated lipoblasts along with lipocytes. The cytologic diagnosis was confirmed by histologic study of the excised tumor.
The cytomorphologic features of an epithelial-myoepithelial carcinoma arising in the submandibular gland are reported. The aspiration smears were cellular, with two cell types present: dark cells showing attempted gland formation and clear cells with vacuolization. The clear cells frequently formed globular masses and had indistinct cytoplasmic membranes. These globular masses of clear cells were usually adjacent to the fragments of dark cells. A striking feature was the presence of numerous naked nuclei.
This study was undertaken to determine whether present regulations for discarding milk from cows treated with sulfadimethoxine (SDM) can be supported by modern analytical methodology. Two groups of milking cows (10 in first group; 11 in the second) were treated orally with SDM at the recommended dose levels for 5 days. The SDM concentration in the milk was determined with 4 methods (Charm Inhibition Assay [CIA], Charm II, enzyme linked immunosorbent assay, and liquid chromatography) during the treatment and the subsequent withdrawal periods. The results of the 4 assays were compared.
The cytologic features of malignant ameloblastoma, a rare tumor of the jaw, are described. Fine needle aspiration smears showed high cellularity, with small basaloid and polygonal epithelial cells with mild to moderate pleomorphism lying singly or in clusters. In Giemsa-stained smears, pinkish stroma with stellate cells or irregularly shaped nuclei and isolated spindle cells were seen in the background. Histopathology of the tumor showed sheets of cells with features of malignancylike atypical mitosis and vascular invasion. The tumor cells stained positive for keratin on immunohistochemistry. A review of cytology smears revealed that the features were sufficiently characteristic of an ameloblastoma, but it was difficult to label the lesion malignant on fine needle aspiration cytology.