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Biomedical subjects

K Minami

Publications and source records attributed to K Minami.

At least 289 records · Page 16Linked to original sources
PubMed1988

[Familial hypertrophic obstructive cardiomyopathy].

The diagnosis of hypertrophic obstructive cardiomyopathy in a 50-year-old man was confirmed by left-heart catheterization and echocardiography, the diagnosis having first been made some years earlier. Both his brother and his children have the same disease. The patient had several cardioversions for recurrent atrial fibrillation with a rapid ventricular rate. Because conservative treatment failed to give a satisfactory result, transaortic myotomy and myectomy were performed. Clinical examination eight months postoperatively showed that the patient's general condition had markedly improved, there was sinus rhythm, and the signs of left ventricular hypertrophy had regressed.

Cardiomyopathy, Hypertrophic↗
PubMed1988

Thrombosis of two St. Jude Medical prostheses in one patient after triple valve replacement. Case report and review of the literature.

Reports of experience with the St. Jude Medical (SJM) valve state that thrombosis of the prosthesis is a rare complication. In a 57-year-old woman, reoperation was necessary 12 months after triple valve replacement using SJM prostheses because of thrombosis of the valves in the tricuspid and aortic positions. Dysfunction of both mechanical valves was detected clinically by changing heart sounds and the appearance of murmurs. Echocardiography and cinefluoroscopy confirmed at least one fixed leaflet of the tricuspid prosthesis, but abnormalities of the aortic prosthesis could not be detected. At reoperation, the SJM prosthesis in the tricuspid position was almost completely thrombosed and was replaced by an Ionescu-Shiley bioprosthesis. A thrombotic formation at the hinge point of the SJM aortic prosthesis was removed. To our knowledge, this is the first report of a thrombotic complication of two SJM prostheses after triple valve replacement in one patient.

Aortic Valve↗
PubMed1988

Operative strategy in combined coronary and carotid artery disease.

In the period between the opening of our heart center in November 1984 and May 1986, 2001 cardiac operations were performed with the aid of cardiopulmonary bypass. Almost three quarters (73.5%, n = 1471) of the patients had coronary artery disease and 20% (n = 359) had acquired valvular heart disease. In 47 of 1471 patients who underwent coronary artery bypass grafting, a simultaneous carotid endarterectomy was performed. They included 36 men and 11 women, aged between 51 and 78 years (mean 64 years). Preoperatively, 12 patients had cerebrovascular symptoms and 35 were neurologically asymptomatic. Twenty-three had unilateral carotid stenosis and 24 had bilateral or multiple vessel disease of the extracranial arteries. All except four patients had triple-vessel coronary artery disease. In three patients with aortic valve disease, coronary bypass, carotid endarterectomy, and aortic valve replacement were performed simultaneously. Cardiopulmonary bypass was instituted before carotid endarterectomy was performed, with mild hypothermia and hemodilution for added protection. Electroencephalographic monitoring was used throughout the operation. Forty-six of the 47 patients survived the operation without neurologic or cardiac complications. One patient had a neurologic deficit with hemiplegia and coma, which was lethal. We conclude that simultaneous endarterectomy of significant extracranial artery stenosis in candidates for coronary bypass is a method safe enough to justify its routine use.

Aged↗
PubMed1987

A new agglutinin from the Tulipa gesneriana bulbs.

Two agglutinins with different agglutinating activity exist in Tulipa gesneriana bulbs. One is the T. gesneriana lectin which agglutinates yeasts as reported previously [Oda, Y. and Minami, K. (1986) Eur. J. Biochem. 159, 239-245]. The other agglutinin is a new one which agglutinates animal erythrocytes and was purified from the tulip bulbs using affinity chromatography on thyroglobulin-Sepharose 4B. The agglutinin agglutinated mouse and rat erythrocytes at a minimum concentration of 2 micrograms/ml and 30 micrograms/ml respectively, but did not agglutinate erythrocytes from other animals and yeasts even at a concentration of 1000 micrograms/ml. The agglutinin appeared homogeneous by disc gel electrophoresis at pH 4.3 and gel filtration. Its relative molecular mass was determined by gel filtration to be approximately 40,000. It was suggested that the agglutinin was composed of two different subunits of 26 kDa and 14 kDa by sodium dodecyl sulfate/polyacrylamide gel electrophoresis analysis. Binding of radioiodinated agglutinin to mouse erythrocytes indicated that the presence of a high-affinity site with a dissociation constant of 2.00 X 10(-9) M. In inhibition experiments thyroglobulin glycopeptides were the most potent inhibitors; thyroglobulin was also a potent inhibitor. Orosomucoid and mucin showed weak inhibition. The other glycoproteins, glycopeptides and sugars examined showed no inhibition.

Agglutination Tests↗
PubMed1987

[Spindle cell squamous carcinoma of the lung--two case reports].

Two cases of spindle cell squamous carcinoma of the lung are presented. Both cases were female heavy smokers aged 73 and 55. The carcinomas, 7.5 and 6.0 cm in diameter respectively, were located at the peripheral portion of the right lower lung lobes. Direct invasion to the diaphragma and metastasis to the chest wall were observed in the first case but no metastasis was observed in the second case. Histologically, both carcinomas showed a biphasic appearance due to the presence of a squamous cell carcinoma component and a spindle cell sarcomatous component with marked cellular pleomorphism, but no neoplastic bone, cartilage or muscle. Transitional area of two components were seen in the second case.

Aged↗
PubMed1986

Isolation and characterization of a lectin from tulip bulbs, Tulipa gesneriana.

A lectin, which agglutinated specifically the yeast cells of the Saccharomyces genus, was isolated from tulip bulbs (Tulipa gesneriana) using affinity chromatography on mannan-Sepharose 4B. Its relative molecular mass was determined by gel filtration to be approximately 67,000. On polyacrylamide gel electrophoresis in sodium dodecyl sulfate, a relative molecular mass of 17,000 was obtained, suggesting that the lectin is a tetramer. Binding studies performed with iodinated lectin indicated that Saccharomyces cerevisiae cells contained approximately 5.7 X 10(6) binding sites per cell, whereas little binding was observed with yeasts other than the Saccharomyces genus, bacteria and animal erythrocytes. D-Mannose, D-mannose 6-phosphate, L-fucose and L-fucosylamine were potent inhibitors of the lectin binding to S. cerevisiae cells, while, D-glucose, D-galactose and D-mannosamine were inactive, indicating that hydroxyl group at C-2 of D-mannose was essential for the lectin binding. Furthermore, inhibition experiments, using various manno-oligosaccharides, suggested that the lectin recognized (1----6)-linked manno-oligosaccharide units larger than mannobiose.

Agglutination↗
PubMed1986

Localized benign mesothelioma of the pleura: case report and review of the literature.

Localized benign mesothelioma of the pleura is a rather uncommon disease with good prognosis after successful tumor extirpation. We present the history of a 66-year-old patient, in whom tumor growth could be observed retrospectively over a period of 6 years. The tumor was extirpated successfully. On the basis of this history and a review of the literature epidemiologic, clinical, radiologic, pathological and prognostic criteria of the tumor are described.

Aged↗
PubMed1986

Left aortic arch, retro-esophageal aortic segment, right descending aorta and right patent ductus arteriosus--a very rare "vascular ring" malformation.

A vascular ring formed by a left aortic arch, a retro-esophageal segment, a right descending aorta and right-sided ductus or ligamentum arteriosum is a very rare anomaly up to now; only 16 cases have been reported in the literature. This report presents the case of an infant suffering from the symptoms of airway and esophageal compression, who was successfully operated on for this anomaly at the age of 5 months. The diagnosis was established by means of esophagogram and angiography. Diagnostic criteria and guidelines for therapy are discussed.

Aorta↗