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Biomedical subjects

K Mimura

Publications and source records attributed to K Mimura.

At least 145 records · Page 8Linked to original sources
PubMed1979

An autopsy case of progressive dementia showing special intraplasmic inclusions in diffuse cerebral cortex.

A 29-year-old male characterized by progressive dementia has been described. Histopathologically, the changes obtained were as follows: 1) Some atrophic nerve cells contained homogeneous round or oval intraplasmic inclusions which could be stained with periodic acid-Schiff and coupled tetrazonium. From these examinations the inclusions consisted of neutral mucopolysaccharide including protein. 2) Mild neuronal loss was diffusely present. 3) Most of the remaining nerve cells were atrophic. The above-described findings were observed diffusely in the whole cortex of the brain. To our knowledge, the present case does not belong to the category of any well-known pathological diseases.

Adult↗
PubMed1979

Studies on the biotransformation of paeonol by means of isotope tracer techniques.--Synthesis and physicochemical properties of carbon-13 and deuterium labeled compounds--.

In order to perform the metabolic study of paeonol (I) in human and animals by using isotope tracer techniques, synthesis of I and its urinary metabolites labeled with carbon-13 or deuterium was investigated. 2-Hydroxy-4-methoxy[d3]acetophenone, 2,5-dihydroxy-4-methoxy[d3]acetophenone, and resacetophenone[acetyl-13C2] were synthesized from methyl iodide-d3, dimethyl sulfate-d6, and acetic acid-1,2-13C2, respectively. Physicochemical studies by IR and NMR spectra showed that stable isotope was not eliminated during the synthetic process of each compound. For the quantification of the metabolites by GC-MS analysis, isotope effect on gas chromatography and fragmentation was studied.

Acetophenones↗
PubMed1978

Ultrastructural study of a patient with progressive dementia showing special intraplasmic inclusions in diffuse cerebral cortex. Mechanism of inclusions production.

Numerous inclusions were diffusely observed in the neurons and glial cells in the cerebral cortex of a patient with progressive dementia. These inclusions were initially produced by rough ER in the cells and gradually enlarged destroying the rough ER membranes. The nature of these inclusions was neutral mucopolysaccaride including protein histochemically. In the nuclei of the nerve cells and glial cells, some types of intranuclear virus-like inclusions were found. The first type was papova virus-like structure with high electron density measured 30--35 nm in diameter. The second type was paramyxovirus-like structure with granulo-fibrilar shape. The third type was large hexogonal core with high electron density measured 100 nm in diameter. These intranuclear virus-like bodies were not specific in the present case; however, it was speculated that intranuclear virus-like inclusions might have a deep relation to change the function of the nuclei and produced large intraplasmic inclusion bodies.

Adult↗