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Biomedical subjects

K Mimura

Publications and source records attributed to K Mimura.

At least 55 records · Page 3Linked to original sources
PubMed1989

Aneurysm in the sequestrated lung and aortitis associated with the malignant rheumatoid arthritis.

A scar phase of rheumatoid aortitis and aneurysms in the sequestrated lung with a lesion continuous to an aortic lesion was found in autopsy specimens from a 50 year-old-woman, who had suffered from generally disseminated carcinoma of the breast. The aorta revealed a scar phase of granulomatous panaortitis continuously from the ascending to the descending thoracic aorta. The media and adventitia of the aorta were largely replaced by scar tissue, although the aortic valve was spared. The systemic arteries in the sequestrated lung were destroyed completely by the necrotizing angiitis and showed saccular aneurysm filled with organizing fibrin thrombus. The pulmonary artery was intact. These findings suggest that the saccular aneurysm in the sequestrated lung was produced by necrotizing angiitis, in association with rheumatoid aortitis.

Aneurysm↗
PubMed1989

Activation of proteases in cerulein-induced pancreatitis.

The activation of zymogen proteases and lysosomal enzyme cathepsin B in the pancreas was investigated in cerulein-induced pancreatitis in rats. Acute pancreatitis was induced by two intraperitoneal injections of 40 micrograms/kg of body weight of cerulein at intervals of 1 h. After the first cerulein injection, the active trypsin and elastase contents in the pancreas tissues significantly increased, and reached the highest level at 3 h after the first injection, followed by peaks at 5 h in the serum amylase and lipase levels and the pancreas wet weight. Cathepsin B contents in pancreas tissues showed a parallel increase with active zymogen enzymes during the first 3 h of pancreatitis. These findings may suggest that the intracellular activation of trypsinogen is an important step in the development of cerulein-induced acute pancreatitis and that cathepsin B plays a role in the activation of trypsinogen in pancreatic acinar cells.

Amylases↗
PubMed1989

Heart rate response to treadmill exercise in children of ages 4-6 years.

In order to investigate some characteristics of physical fitness in children, we measured the heart rate of 1069 kindergarten children (aged 4-6 years) and 20 adults during treadmill running. After analyzing the data we obtained the following results: heart rate before, during, and after the running tended to diminish with the increase in age of the subjects in both men/boys and women/girls. The relationship of the heart rates before running and the maximum heart rates during in 25 m run, standing long jump, and softball throw, showed a significant level of 5-0.1% in both boys/men and girls/women. The heart rates of children before, during and after running were higher than those of adults. The rate of increase in heart rate was higher in adults, while more rapid recovery of heart rate was observed in children, when compared to adults.

Adult↗
PubMed1989

Prerequisites in distance running performance of female runners.

We investigated which attribute or what combination of attributes would best account for distance running performance of female runners. The subjects were 30 well-trained female distance runners, aged 19 to 23 years. Anthropometric and body composition characteristics, pulmonary function characteristics, blood properties, and cardiorespiratory function characteristics were measured at rest or during submaximal and maximal exercise. Analyses of the data showed that the relationship of oxygen uptake corresponding to lactate threshold (VO2T, ml.kg-1.min-1) with each distance running performance was substantially higher as compared with the relationship of other independent variables including maximal oxygen uptake (VO2max). Furthermore, multiple regression analysis indicated that running performances in 3,000m, 5,000m, and 10,000m are best accounted for by a combination of VO2/LT (X1), fat-free weight (X2), and/or mean corpuscular volume (X3). A multiple regression equation for predicting the 5,000m (Y, s) running performance was formulated as Y = -14.75X1-3. 03X2-5.79X3 + 2282.1. We suggest that VO2max would not stand alone as a decisive factor of distance running success in female runners, and that the distance running performance could be better accounted for by a combination of several attributes relating to lactate threshold, body composition, and/or hematological status. The linear regression of the predicted running performance on the actually measured running performance can be accepted in the range of 986-1197s.

Adult↗
PubMed1988

Cytochrome oxidase histochemistry in the effect of light deprivation on the fly visual system.

Deprivation of visual experience for a short time during the early period postemergence in the fly influences strongly the development of visual pattern discrimination. Cytochrome oxidase histochemistry was used to examine the effect of visual deprivation on the development of the neuronal network in the optic lobe. Flies in which one compound eye was covered immediately after emergence were raised under normal light and dark conditions (LD). Other flies were raised without covering of the compound eyes under LD or continuous darkness (DD) as controls. At various periods of postemergence flies from the 3 groups were used for histochemistry. The results indicated that the deprivation caused by unilateral eye covering produced a decrease in cytochrome oxidase staining of the covered side of the retina and optic lobe, but not in the central part of the brain. This asymmetry in staining was not seen in flies of 1-5 days postemergence but became evident after the sixth day postemergence. When flies were raised in DD until the 5th day postemergence and then in LD, the development of asymmetry in cytochrome oxidase staining was delayed. These results confirm previous behavioral experiments on visual deprivation. Both suggest that visual deprivation during the early period of postemergence leads to a long-lasting decrease in neuronal activity.

Animals↗
PubMed1987

The effect of partial covering of the eye on the results of selective deprivation of visual pattern in the fly.

Visual deprivation experiments have demonstrated that the development of pattern discrimination in the fly depends on experience in the early period after emergence. Based on this finding, a behavioral study was done in which flies had their eyes partially covered during selective deprivation treatment. This study demonstrated that several simple visual patterns are mainly identified in a restricted, pattern-specific region of the compound eyes, and also that the effect of visual deprivation is produced in the unilateral compound eye and is not transferred to the contralateral side.

Animals↗
PubMed1987

[Microangiopathic hemolytic anemia (MAHA) observed after administration of mitomycin C (MMC)].

An autopsy case of MAHA induced by MMC is reported. The patient received MMC and tegafur following operation for colon adenocarcinoma. Five months after the operation, the patient developed MAHA, thrombocytopenia, and renal impairment. MAHA was exacerbated by blood transfusions and he died of extensive pulmonary edema. Autopsy findings showed no residual carcinoma but microangiopathies of the kidney, such as fibrinoid necrosis of the small arteries, arterioles, and glomerular capillaries, and intimal proliferation in the small arteries were evident. As renal impairment is usually irreversible in MAHA by MMC, careful follow-up of renal function should be emphasized in patients receiving MMC.

Adenocarcinoma↗
PubMed1987

Persistence and extinction of the effect of visual pattern deprivation in the fly.

Visual pattern discrimination in the fly (Boettcherisca peregrina) is dependent on post-emergence experience of light and visual patterns (Mimura 1986). A behavioural study was made on the persistence of the functional modification that results from visual deprivation. When the fly was kept in the dark for 5 days post-emergence, the development of visual pattern discrimination was impaired completely, irrespective of the subsequent light condition, while photosensitivity was not impaired. A "deprivation" effect could also be produced by exposing the fly for at least 1 h soon after emergence to a definite pattern instead of its usual contrasted environment. Persistence of this deprivation effect depended on the subsequent light conditions: The effect was more persistent when the flies were kept in continuous darkness (DD) than when they were raised in light-dark (LD) environment; and The longer the presentation of a definite pattern, the more stable was the deprivation effect. Extinction of the deprivation effect was replaced with the development of normal pattern discrimination. In flies that had experienced a lighted, white, unpatterned environment after emergence, the normal development of pattern discrimination was impaired. This deprivation effect was persistently maintained when flies were kept in DD, but when flies were exposed to this environment for 5 h or more and then kept in LD, normal pattern discrimination developed gradually.

Animals↗