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Biomedical subjects

K Millar

Publications and source records attributed to K Millar.

At least 73 records · Page 4Linked to original sources

Noise and the "rehearsal-masking hypothesis".

This study examines the proposal that continuous loud noise impairs short-term recall by masking the inner speech necessary to rehearse material in memory (Poulton, 1976 a, 1977 b). The "masking hypothesis" contrasts with previous theories which relate recall impairment in noise to the latter's action in over-arousing the individual or inducing changes in attentional deployment. Separate groups performed a visual, serial eight-consonant recall task in either 92 dBA "noise" or 75 dBA "quiet" and in "normal" or "suppressed" rehearsal conditions. The masking hypothesis predicted that noise would impair recall relative to quiet in normal rehearsal conditions. But where the rehearsal of both groups was already suppressed by a concurrent articulatory task, recall would not differ between the groups through noise-masking then being irrelevant. Total correct recall scores appeared to confirm the masking hypothesis but the pattern of serial order recall showed differences between noise and quiet in suppressed rehearsal conditions which seemed better explained by an attentional influence of noise. Further, reduced commission and acoustic confusion errors in noise were not consistent with the predictions of the masking hypothesis. It was concluded that noise-masking could not be refuted but that attentional changes due to the arousing action of noise might also be active determinants of recall.

Adult↗

Changes in ventricular recovery properties during and after temporary coronary artery occlusion.

The sequence of localized changes in ventricular repolarization time during and after temporary coronary artery occlusion was studied in 10 open chest dogs. Immediately after the onset of coronary occlusion functional refractory periods (FRPs) prolonged slightly in the ischemic area, then shortened with continued occlusion. Within the first minute following release of occlusion, FRPs underwent a further brief decrease in duration. By varying the period of occlusion from 1 1/2 to 6 1/2 min, evidence was obtained that the post-release shortening of RFPs was temporally related to release of the clamp and not to the onset of occlusion. Ventricular fibrillation occurred in 2 dogs, in each instance soon after release of the coronary artery occlusion. The possible relationship of these experimental FRP changes to waveform abnormalities and arrhythmias in ischemic heart disease is discussed.

Animals↗

Diagnosis of old inferior myocardial infarction by body surface isopotential mapping.

Body surface isopotential maps obtained from 28 patients with old inferior wall myocardial infarction were compared with maps from 120 normal subjects. The 12 lead electrocardiogram of 8 of the 28 patients (29 percent) with inferior wall infarction was normal or showed only nondiagnostic ST-T wave abnormalities at the time the isopotential maps were obtained. In all patients with inferior wall infarction the isopotential map showed a minimum (area of negative potentials) on the inferior or right thoracic surface during the early portions of the QRS complex. This finding was observed in patients with normal or nonspecific abnormalities in the 12 lead electrocardiogram as well as those with QRS abnormalities. By contrast, the minimum during the early QRS complex in normal subjects was located on the right upper back and shoulder region...

Back↗

Local ventricular repolarization changes due to sympathetic nerve-branch stimulation.

Functional distributions of individual cardiac nerves distal to the stellate ganglia were determined in 30 open-chest, anesthetized dogs by mapping sites of refractory-period shortening during stimulation of the nerves. On the right, recurrent cardiac nerve stimulation produced marked shortening of refractory periods in the interventricular septum, and lesser changes on the anterior heart surface. On the left, ventromedial cardiac nerve stimulation shortened refractory periods in a similar distribution, but changes were not marked as with the recurrent cardiac nerve. The other left-side nerve that produced repolarization changes, the ventrolateral cardiac nerve, produced marked refractory-period changes on the posterior heart surface. Its distribution showed little overlap with that of the ventromedial or recurrent cardiac nerves. T waves inverted in an electrocardiographic Y lead during recurrent cardiac and ventromedial cardiac nerve stimulation, while ventrolateral cardiac nerve stimulation increased the positivity of T waves in that lead. The cardiac distributions of individual nerves documented in this study provide an anatomical basis for localized alterations in ventricular electrophysiologic properties.

Animals↗