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Biomedical subjects

K Miehlke

Publications and source records attributed to K Miehlke.

At least 19 recordsLinked to original sources
PubMed1988

[D-penicillamine--a retrospective view].

D-penicillamine was discovered in 1943. At the beginning of the 1960s it was introduced into the treatment of rheumatoid arthritis. Since then, its efficacy and adverse effects have become very well known. According to this experience, D-penicillamine, similarly to gold, is acknowledged as a disease-modifying drug in the treatment of rheumatoid arthritis.

Arthritis, Rheumatoid↗
PubMed1987

Results of a phase-II clinical trial on treatment of rheumatoid arthritis with recombinant interferon-gamma.

In an open, non-randomized clinical trial conducted at multiple centres, 49 patients with rheumatoid arthritis were treated with recombinant interferon-gamma for 20 days. The study was carried out in two sub-studies. In the first, the total daily dose of interferon-gamma was 50 micrograms; in the second, 100 micrograms. Of the 49 cases, 40 were evaluable for statistical analysis; 24 of these patients (60%) responded to therapy, according to the criteria of a successful outcome laid down in the study protocol, and were classified as responders. In responders, the clinical parameters investigated improved with both dosages. The lower dosage differed from the higher one in having a markedly lower incidence of side-effects. The results lead to the conclusion that a randomized double-blind phase-III clinical trial should be performed.

Adult↗
PubMed1975

[The effect of D-penicillamine on the course of chronic polyarthritis].

The report deals with 8 years of clinical experience with long-term application of D-penicillamine in rheumatoid arthritis. The mode of action of D-penicillamine is discussed. It seems most probable that the influence of D-penicillamine implies an inhibition of the immunreaction.

Arthritis, Rheumatoid↗