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Biomedical subjects

K Meyer

Publications and source records attributed to K Meyer.

At least 271 records · Page 15Linked to original sources
PubMed1971

3,6-Anhydroglucosaminyl formation in mucopolysaccharides.

Treatment of keratosulfates with alkali leads to the formation of 3,6-anhydroglucosaminyl groups in high yield. A similar reaction takes place with heparin and heparitin sulfate, though to a lesser extent. The anhydrosugar was isolated and compared with synthetic 3,6-anhydroglucosamine. The isolated compounds were identical in ion exchange chromatography in the amino acid analyzer and on Dowex 50 H(+) eluted with dilute HCl. The spectra of the isolated and synthesized anhydrosugar were identical in infrared and nuclear magnetic resonance. Derivatized compounds were identical in gas-liquid chromatography and mass spectroscopy. The peracetylated compound isolated from keratosulfate gave the nuclear magnetic reasonance and fragmentation pattern of the postulated compound. The reaction is expected to be useful in structural studies of hexosamine-containing polymers.

Amino Acids↗
PubMed1971

Mucopolysaccharide and protein--polysaccharide of a transplantable rat chondrosarcoma.

Two mucopolysaccharides, chondroitin 4-sulfate (97.8%) and hyaluronic acid (1.2%), were isolated after exhaustive proteolysis of a transplantable chondrosarcoma of the rat. The chondroitin 4-sulfate was fractionated into three fractions of varying degrees of sulfation and chain length. Keratan sulfate and chondroitin 6-sulfate were absent. Extraction of the fresh tumor gave two protein-polysaccharides of similar carbohydrate composition, one soluble in 0.5 M NaCl, the other insoluble. The latter was solubilized in 4 M guanidine.HCl. A dialyzable fraction from the 4 M guanidine solution may be responsible for the insolubility. Both protein-polysaccharides were antigenic and cross-reacted with similar fractions of bovine and human cartilage.

Animals↗