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Biomedical subjects

K Melby

Publications and source records attributed to K Melby.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Surgical treatment of necrotizing fasciitis].

We present nine patients with necrotizing fasciitis. Two of them had Fourniers gangrene. Predisposing factors included diabetes mellitus, alcohol and drug abuse. Local signs were redness, swelling and pain rapidly followed by fever and deterioration in the patient's general condition. Soft tissue-gas was observed in all patients. It was found either clinically, on roentgenograms or by CT. Bacteria were found in blood cultures and/or necrotic tissues in all patients. The dominating treatment was radical surgical excision and early reexplorations. Antibiotics, intensive care support and early parenteral nutrition were given. Four patients were given hyperbaric oxygen treatment. The overall mortality rate was 11%. Amputation of one lower extremity became necessary in three patients. In these cases 4-8 days had elapsed between the onset and the first surgical excision. We find it important to underline early diagnosis and radical surgical excision in patients with necrotizing fasciitis.

Adult↗
PubMed1989

[Campylobacter pylori. Determination of gastric colonization and its clinical relevance].

While evidence suggesting a statistical association between Campylobacter pylori and chronic active antral gastritis is convincing, the role which the organism may play in the pathogenesis of this condition and in the case of peptic ulcer remains to be elucidated. The development of safe, non-invasive diagnostic tests suitable for population studies greatly facilitates this investigative process. This article presents a brief review of currently available methods of diagnosing C pylori colonization in the stomach and discusses their possible application in the field of clinical gastroenterology.

Campylobacter↗
PubMed1989

[Intestinal spirochetes].

We report a case of intestinal spirochaetosis. The bacteria were seen by light microscopy and reacted in an indirect immunofluorescence test on the biopsy material with serum with high levels of IgG antibodies against Borrelia burgdorferi. The patient's own serum had no detectable antibody activity against the bacteria. No inflammatory response was observed. Aspects of these findings are discussed.

Adult↗
PubMed1989

The in vitro activity of norfloxacin, ofloxacin and ciprofloxacin and other antibiotics in current use against Neisseria gonorrhoeae.

One hundred non-beta-lactamase-producing and 50 beta-lactamase-producing strains of Neisseria gonorrhoeae serogroup WI and WII/III were tested in vitro by an agar dilution method against a panel of antibiotics including ciprofloxacin, ofloxacin and norfloxacin. All strains irrespective of beta-lactamase production and serogroup allocation, were inhibited by 0.125 mg/l of all quinolones. Ciprofloxacin turned out to be most active followed by ofloxacin and norfloxacin. All strains were also inhibited by low concentrations of cefotaxime (MIC less than 0.25 mg/l). Many strains mostly among the beta-lactamase-producing strains were resistant (MIC greater than 4 mg/l) to doxycycline. Ampicillin is still active against the majority of non-beta-lactamase-producing strains. The majority of the strains belonged to serogroup WII/III which are known to be less sensitive to penicillin G and ampicillin.

Ampicillin↗
PubMed1988

[Lung abscess].

Explore the source record for details and available documents.

Adolescent↗
PubMed1988

Bacteriological findings and clinical symptoms in relation to clinical outcome in puerperal mastitis.

Clinical symptoms, bacterial content in breast milk and treatment were recorded in 43 women in Oslo with puerperal mastitis. Patients with a favorable (n = 35) and unfavorable outcome (n = 8) (defined as abscess formation and/or symptom relief after more than 7 days) were compared. The group with unfavorable outcome was characterized by increased delay between symptoms and time for consultation, higher score of clinical symptoms and higher frequency of Staphylococcus aureus. A higher frequency of S. aureus was found in the affected breasts than in the unaffected breasts. There was no difference concerning the frequency of coagulase-negative staphylococci and overall bacterial counts, either between milk from affected and non-affected breasts, or between milk from non-affected breasts and milk from healthy donors. The present investigation indicates that penicillin treatment is questionable when considering that untreated cases healed almost as quickly as treated ones, and that 70% of the S. aureus strains were resistant to phenoxymethylpenicillin. It is concluded that present bacterial examinations in breast milk are of limited help in deciding who needs antibiotic treatment.

Adult↗
PubMed1988

Antibodies against Campylobacter jejuni/coli in patients suffering from campylobacteriosis or inflammatory bowel disease.

Sera from 74 patients from the Oslo area and 21 from Northern Norway with compylobacteriosis were analysed for antibodies against an antigen mixture comprising seven Campylobacter jejuni/coli strains including a PEN 0:6,7 isolate representing the most common serotype in Northern Norway. Seventy-seven per cent of the campylobacter patients from the Oslo area and 86% from Northern Norway had elevated antibody levels. Thirty-seven out of 57 (65%) seropositive patients from Oslo and 12 out of 18 (67%) from Northern Norway were positive in more than one immunoglobulin class. None of the patients, all from Northern Norway (N = 56), with inflammatory bowel disease i.e. Mb. Crohn or ulcerative colitis diagnosed for the first time, had elevated antibody levels in two immunoglobulin classes. Apparently campylobacteriosis is not associated with the precipitation of these diseases. Two sets of blood donor sera, from Oslo (N = 28) and Tromsø (N = 37) respectively, served as reference. The IgG antibody levels against C. jejuni/coli antigens in the blood donor group from Tromsø were higher than in the Oslo group.

Adolescent↗
PubMed1987

Antibody response in patients infected with Campylobacter jejuni/coli assayed with a complement fixation test and a DIGELISA method.

Two methods for the detection of antibodies against Campylobacter jejuni/coli, a complement fixation test (CFT) and a DIG-ELISA method, were tested against a panel of single sera from 36 coproculture positive patients. Twenty-five were positive in CFT compared to 31 in the other system. Twenty-three out of 25 CFT positive sera were positive in the ELISA method. Seven sera were positive only for IgA antibodies thus negative in the CFT. CFT may be useful for the detection of IgG/IgM antibodies against C. jejuni/coli. However, serum IgA may be a valuable marker for infections with C. jejuni/coli. Methods such as DIG-ELISA may identify such cases.

Antibodies, Bacterial↗