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Biomedical subjects

K McKenzie

Publications and source records attributed to K McKenzie.

At least 55 records · Page 3Linked to original sources
PubMed1995

Animal models for breast cancer.

Rodent mammary tumors induced by chemical carcinogens have proven to be very useful in the genetic analysis of initiation, promotion and progression of mammary carcinogenesis. We are studying rat mammary carcinomas induced by the chemical carcinogen, N-nitroso-N-methylurea. The earliest genetic event observed in the mammary gland is the activation of Ha-ras oncogenes, which is followed by promotion of the initiated cells by hormones involved in puberty. Preferential amplification of the mutated Ha-ras allele, of PRAD-1 and IGF2, loss of expression of the mitogenic growth factor gene, MK, and mutation in the tumor suppressor gene, p53, are seen in the mammary tumors during tumor progression.

Animals↗
PubMed1995

Stories and solutions in psychotherapy with adolescents.

Many therapists find working with adolescents to be a difficult and unrewarding task. Drawing on the ideas of solution-oriented therapy and the narrative approaches to counseling, the authors provide a framework for cooperative, therapeutic work with adolescents. Strategies which enable therapists to gain an understanding of the world view of adolescents by listening to their stories are discussed. By hearing and understanding the stories adolescents tell about their lives, therapists can recognize and tap into the strengths and resources of these young persons.

Adolescent↗
PubMed1993

Training effects on maternal and fetal glucose uptake following acute exercise in the rat.

The purpose of the present study was to determine the effects of chronic maternal exercise on glucose uptake in maternal tissues after one bout of treadmill running during late gestation in the rat and to determine the effects on glucose accumulation in the fetus and placenta. Trained pregnant animals (PR) ran at 30 m.min-1, on a 10 degrees incline for 1 h on day 20 of gestation with a similarly treated trained nonpregnant group (NPR). Immediately after the run the animals were infused with a bolus of 1 g.kg-1 body wt as a 50% dextrose solution mixed with 2-deoxy-D-[1-3H] glucose through a carotid catheter. Sedentary pregnant (P) and nonpregnant animals (C) were also infused with the solution after no food and water for the same time frame. After 60 min, tissues were analyzed for radioactivity. Radioactive tracer was augmented in the red gastrocnemius and soleus of the PR group and the soleus of P rats. However, tracer accumulation in the fetus and placenta of the trained animals was not different than P animals. These results indicate that acute exercise in trained animals increased glucose uptake in maternal skeletal muscles without compromising conceptus glucose accumulation.

Animals↗
PubMed1991

Effect of stem modulus in a total hip arthroplasty model.

The purpose of this study was to determine the biological effects of the elastic modulus of the femoral stem in canine hip arthroplasty. Cementless total hip arthroplasty was performed in 12 dogs, six had a low elastic modulus polyacetal resin stem and six had a high modulus stainless steel stem. The components were otherwise similar. At six and 12 months after operation, radiographic and histomorphometric analysis showed that those with steel implants had more cortical porosity than did the other group (p less than 0.01). We suggest that the elastic modulus of the implant is an important factor in controlling cortical bone resorption. A low modulus femoral prosthesis can significantly decrease bone resorption which might otherwise eventually lead to implant failure.

Animals↗
PubMed1989

Comparison of microscale ultracentrifugation and equilibrium dialysis for the determination of the unbound fraction of theophylline in human serum.

A microscale ultracentrifugation procedure for the measurement of free theophylline in serum is described and evaluated by comparison with an equilibrium dialysis method. Provided an ultracentrifuge is available, micro-ultracentrifugation is a simple, cost-effective technique for the routine determination of free drug fractions.

Costs and Cost Analysis↗
PubMed1989

The Mauriac syndrome.

An insulin-dependent diabetic was diagnosed at the age of 7 years. After two years of satisfactory control she began to have several bouts of hospitalization with hyperglycaemic ketoacidosis, and developed tender hepatomegaly, which persisted to age 11 years. With restabilisation of her diabetes, the liver regressed and she continued to maintain good health for another 1 1/2 years when she died suddenly while asleep. Post-mortem examination by the coroner revealed ascites in the abdomen, hepatomegaly and fatty metamorphosis of the liver. Her diabetes control required up to 2.3 i.u. insulin per kg body weight per day plus a 1,900 calorie diet. Her growth was well below the tenth percentile, weight for height (Harvard charts). This clinical picture of high insulin dosage, hepatomegaly, unstable diabetes and growth failure approximates to the Mauriac syndrome.

Child↗
PubMed1986

The protein metabolic response to short-term starvation in man.

Plasma protein concentrations, in particular the serum albumin concentration, are often quoted as indicators of nutritional state in surgical patients. Injury also affects the circulating concentrations of these proteins. Twenty students were subjected to a 3-day total fast and the concentration of plasma proteins, generally affected by trauma, determined before and after the fast. The only protein to show any negative response was retinal binding protein which fell by 16% during the starvation period (p < 0.001). Albumin, the protein often used as a nutritional index, demonstrated a significant (p < 0.001) increase during this period. This was not related to changes in the hydration state of the subjects.

Journal Article↗