Biomedical subjects

K McFarland

Publications and source records attributed to K McFarland.

At least 19 recordsLinked to original sources

PubMed2002

Lateralization of speech production using verbal/manual dual tasks: meta-analysis of sex differences and practice effects.

The present paper reviews the findings of 30 years of verbal/manual dual task studies, the method most commonly used to assess lateralization of speech production in non-clinical samples. Meta-analysis of 64 results revealed that both the type of manual task used and the nature of practice that is given influence the size of the laterality effect. A meta-analysis of 36 results examining the effect size of sex differences in estimates of lateralization of speech production indicated that males appear to show slightly larger laterality effects than females.

Attention↗

PubMed2002

Repeated cocaine administration alters the electrophysiological properties of prefrontal cortical neurons.

Recently it has become clear that some of the symptoms of addiction such as relapse to drug-taking behavior arise, in part, from a dysfunction in cognitive and emotional processing. This realization has promoted investigations into the physiology and pathophysiology of forebrain circuits that are both innervated by dopamine and play an important role in cognitive processing, including the prefrontal cortex. In order to study long-term neuroadaptations occurring in the prefrontal cortex of the rat as a consequence of psychostimulant administration, cocaine was repeatedly administered in either a contingent or a non-contingent manner. At least 2 weeks following the last cocaine injection, in vivo intracellular recordings were made from neurons located in the deep layers of the prefrontal cortex. Repeated cocaine administration abolished the presence of membrane bistability normally present in neurons located in the limbic prefrontal cortex. These results indicate that repeated exposure to cocaine produces enduring changes in the basal activity of neurons in the prefrontal cortex that may contribute to previously identify cognitive and emotional dysfunctions in cocaine addicts.

Action Potentials↗

PubMed2001

The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior.

The role of limbic-striato-pallidal circuitry in cocaine-induced reinstatement was evaluated. The transient inhibition of brain nuclei associated with motor systems [including the ventral tegmental area (VTA), dorsal prefrontal cortex (dPFC), core of the nucleus accumbens (NAcore), and ventral pallidum (VP)] prevented cocaine-induced reinstatement. However, only the VP proved to be necessary for food reinstatement, suggesting that the identified circuit is specific to drug-related reinstatement. Supporting the possibility that the VTA-dPFC-NAcore-VP is a series circuit mediating reinstatement, simultaneous unilateral microinjection of GABA agonists into the dPFC in one hemisphere and into the VP in the contralateral hemisphere abolished cocaine reinstatement. Although dopamine projections from the VTA innervate all three forebrain nuclei, the blockade of dopamine receptors only in the dPFC antagonized cocaine-induced reinstatement. Furthermore, DA administration into the dPFC was sufficient to elicit a reinstatement in drug-related responding. These data demonstrate that dopamine release in the dPFC initiates a dPFC-NAcore-VP series circuit that mediates cocaine-induced drug-seeking behavior.

Animals↗

PubMed2001

Post-Traumatic amnesia: consistency-of-recovery and duration-to-recovery following traumatic brain impairment.

The aim of this research was to examine the nature and order of recovery of orientation and memory functioning during Post-Traumatic Amnesia (PTA) in relation to injury severity and PTA duration. The Westmead PTA Scale was used across consecutive testing days to assess the recovery of orientation and memory during PTA in 113 patients. Two new indices were examined: a Consistency-of-Recovery and a Duration-to-Recovery index. A predictable order of recovery was observed during PTA: orientation-to-person recovered sooner and more consistently than the following cluster; orientation-to-time, orientation-to-place, and the ability to remember a face and name. However, the type of memory functioning required for the recall face and name task recovered more consistently than that required for memorizing three pictures. An important overall finding was that the "order-of-recovery" of orientation and memory functioning was dependent upon both the elapsed days since injury, and the consistency of recovery. The newly developed indices were shown to be a valuable means of accounting for differences between groups in the elapsed days to recovery of orientation and memory. These indices also clearly increase the clinical utility of the Westmead PTA Scale and supply an objective means of charting (and potentially predicting) patients' recovery on the different components of orientation and memory throughout their period of hospitalization.

Adolescent↗

PubMed2000

Effect of sequential transdermal progesterone cream on endometrium, bleeding pattern, and plasma progesterone and salivary progesterone levels in postmenopausal women.

BACKGROUND: Transdermal progesterone is being used in some countries as a purported treatment for menopausal symptoms, either alone or prescribed in conjunction with estrogen, but little information exists regarding the biological activity and effectiveness of this method of delivery of progesterone in protecting the endometrium from excess proliferation. This study was designed to evaluate the use of sequential transdermal progesterone. End-points evaluated included endometrial cellular response and bleeding pattern as well as plasma hormone levels and salivary progesterone estimations. METHOD: Twenty-seven postmenopausal women were treated with continuous transdermal estrogen (28-day cycle) and a cream containing 16, 32 or 64 mg of progesterone in each 4-cm extrusion from a tube of Pro-Feme administered daily in a sequential (days 15-28 of cycle) regimen. Blood and endometrial samples were analyzed for progesterone response prior to therapy, after the first 14 days of unopposed transdermal estrogen and following 14 days of transdermal progesterone. Saliva samples were taken during the last 14 days of the 84-day study, when the final progesterone cream therapy was being applied. RESULTS: Hormone assay indicated that physiological levels of estradiol were achieved, but progesterone levels were insufficient to induce any detectable change in the endometrium. Only one patient experienced bleeding during the study period. Levels of salivary progesterone were so variable as to be considered completely unreliable in determining the potential influence on biological activity. INTERPRETATION: Pro-Feme transdermal progesterone administered in a 16-, 32- or 64-mg daily dose for 14 days in a sequential regimen does not appear to be effective in inducing a secretory change in a proliferative endometrium. Salivary progesterone levels were not of value in managing the therapy of postmenopausal women.

Administration, Cutaneous↗

PubMed1999

Micronised transdermal progesterone and endometrial response.

Sequential transdermal progesterone administered with continuous transdermal oestrogen was insufficient to increase circulating blood progesterone concentrations or induce a secretory response in proliferating endometrium.

Administration, Cutaneous↗

PubMed1999

Haloperidol does not attenuate conditioned place preferences or locomotor activation produced by food- or heroin-predictive discriminative cues.

The present study examined whether a discriminative cue previously predictive of food or heroin reinforcement could activate and direct behavior in an environment that had never been paired with primary reinforcement. Olfactory cues, predicting the availability (S+) or unavailability (S-) of either heroin (0.1 mg/kg i.v.) or food (45 mg Noyes food pellets) reinforcement in the goal box of a straight-arm runway, were later tested in a separate environment for their ability to elicit locomotion (activate behavior) or induce a conditioned place preference (direct behavior). Presentation of the S+, but not the S-, resulted in a reliable increase in spontaneous locomotor activity that was not blocked by pretreatment with the dopamine receptor antagonist, haloperidol. Similarly, subjects displayed a preference for a novel location in which the S+, but not the S-, was placed. This preference was also unaltered by pretreatment with haloperidol. These data suggest that discriminative cues can profoundly affect behavior, even in environments that have themselves never been associated with primary reinforcement. Additionally, the conditioned motivational quality of these cues is unaltered by treatment with the same dopamine receptor antagonist shown in previous work to attenuate the primary reinforcing properties of heroin and food.

Animals↗

PubMed1998

Haloperidol does not affect motivational processes in an operant runway model of food-seeking behavior.

The present experiment examined the effects of dopamine receptor antagonism on subjects' motivation to seek food. Rats were trained to discriminate between 2 olfactory cues predicting either the presence (S+) or absence (S-) of food reinforcement in the goal box of a straight-arm runway. Rats learned to traverse the alley quickly when presented with the S+ and much more slowly when presented with the S-. Haloperidol pretreatment was unable to alter this pattern of behavior (i.e., rats still ran quickly when presented with the scent that predicted food availability). Thus, it seems that the same dopamine antagonist treatments that have been shown to disrupt food reinforcement do not prevent the food-seeking behavior produced by presentation of food-predictive cues.

Analysis of Variance↗

PubMed1998

Naloxone blocks reinforcement but not motivation in an operant runway model of heroin-seeking behavior.

The present study examined the effects of opiate receptor antagonism on both the motivation to seek heroin and the reinforcing consequences of heroin administration. Subjects were trained to discriminate between olfactory cues predicting either the delivery of intravenous heroin reinforcement (S+) or saline (S-). Subjects were then tested in the presence of the opiate receptor antagonist, naloxone (0.5, 1.0, or 3.0 mg/kg intraperitoneally). Naloxone had no effect on either S+ or S- trials. However, 24 hr later on the first posttreatment trial, subjects that had received heroin in the presence of naloxone (on the previous trial) now traversed the alley more slowly when presented with the S+. These data suggest that although the motivation to seek heroin was not disrupted by naloxone, the reinforcing consequences of heroin administration were.

Animals↗

PubMed1997

Reinstatement of drug-seeking behavior produced by heroin-predictive environmental stimuli.

The current study examined whether stimuli predictive of heroin availability were capable of inducing a relapse of drug-seeking behavior in an operant runway task. Olfactory stimuli (orange and almond food extract) served as discriminative cues about the availability (S+) or unavailability (S-) of heroin reinforcement (a single 0.1 mg/kg IV infusion) in the goal box of a straight arm runway. Following discrimination training, the running response was extinguished in the absence of the olfactory cues. On a single trial, the discriminative stimuli were then tested for their ability to reinstate running behavior prior to presentation of the heroin reinforcer. Subjects presented with the S+ on test day took significantly less time to traverse the alley than they did on the final day of extinction, while those subjects presented with the S- on test day continued to run slowly. These results demonstrate, in an animal model of drug self-administration, that environmental discriminative cues can produce a relapse in drug seeking behavior following a period of abstinence. The response-reinstating properties of the S+ odor were unaltered by pretreatment with any of three doses of haloperidol (0.0, 0.15 or 0.3 mg/kg IP), suggesting that the motivating properties of heroin-predictive stimuli or cues remain intact during dopamine receptor antagonism.

Animals↗

PubMed1997

Mild head injury and speed of information processing: a prospective study of professional rugby league players.

The sensitivity of several short tests of speed of information processing to the effects of mild head injury in rugby league football was investigated. The measures used were the Symbol Digit Modalities Test, the Digit Symbol Substitution Test, and the Speed of Comprehension Test. Two studies were conducted, the first to examine the effect of practice, the second to determine sensitivity to cognitive impairment immediately following injury. The first study established alternate form equivalence and demonstrated that performance on the Speed of Comprehension and Digit Symbol Substitution tests improved with practice, whereas the Symbol Digit Modalities test remained stable. A second study of 10 players who subsequently sustained mild head injuries showed that measures of speed of information processing were sensitive to impairment in the postacute phase, whereas an untimed task of word recognition (Spot-the-Word) was not. Speed of Comprehension was more sensitive to postinjury impairment than either the Digit Symbol Substitution or Symbol Digit Modalities tests. A repeated baseline assessment before injury using the higher score to reflect a player's potential, allowed measurement of impaired performance on sensitive tests.

Acute Disease↗

PubMed1996

Addition of anticholinergic solution prolongs bronchodilator effect of beta 2 agonists in patients with chronic obstructive pulmonary disease.

A randomized, double-blind placebo-controlled clinical trial was designed to assess the safety, efficacy, and duration of the bronchodilation resulting from the addition of 500 micrograms of ipratropium bromide (Atrovent; Boehringer Ingelheim, CT) inhalation solution to standard small volume nebulizer treatments with 2.5 mg albuterol inhalation solution. A total of 195 patients (63% men, average age 64 years) with > 10 pack-year smoking histories and stable, moderate-to- severe chronic obstructive pulmonary disease (COPD; forced expiratory volume in 1 second [FEV1] 1.02 liter, 38.8% predicted) from eight university-affiliated chest clinics in seven U.S. cities were enrolled into the study. Asthma, rhinitis, and eosinophilia were exclusions, as was daily use of > 10 mg of prednisone (or 20 mg on alternate days). There was a 2-week stabilization period during which the patients were instructed in the use of the small volume nebulizers, which they used three times daily with albuterol alone. They were asked to keep daily logs of peak flow rates, pulmonary symptoms, and additional medication usage. On their test day 1 the subjects came to the pulmonary function laboratory having been off theophylline for 24 hours and beta 2-agonists for 12 hours and performed a baseline spirometry. They then received their morning small volume nebulizer treatment of albuterol to which was added either 500 micrograms if ipratropium bromide or a saline placebo. Spirometry was repeated at 15, 30, and 60 minutes, and then hourly for 8 hours. Subjects then took home a 2-week supply of albuterol and test drug for thrice daily use in their small volume nebulizer. They were evaluated for pulmonary symptoms and adverse effects every 14 days. The 8-hour spirometry was repeated on test day 43 and finally on test day 85. Primary data evaluated were the peak increase in FEV1 and the area between the FEV1 baseline value and the 8-hour FEV1 curve. Similar calculations were made for forced vital capacity (FVC) and 25-75% forced expiratory flow (FEF25-75%). On test day 1 the peak increase in FEV1 for the ipratropium bromide + albuterol subjects was 26% greater than those on placebo + albuterol (p < 0.003). The area under the 8-hour FEV1 curve was 64% greater in those given ipratropium bromide on test day 1 (p < 0.0002). Similar increases were seen in FVC and FEF25-75%. The peak improvements in FEV1 and FVC with the addition of ipratropium bromide to albuterol were maintained on test days 43 and 85. Considering the safety and efficacy profiles of this combination, the data would suggest that ipratropium bromide inhalation solution should be considered first-line therapy for those patients with COPD requiring small volume nebulizer treatments.

Administration, Intranasal↗

PubMed1995

Haloperidol differentially affects reinforcement and motivational processes in rats running an alley for intravenous heroin.

The role of drug-paired environmental stimuli in opiate self-administration was investigated by exposing animals to discrete cues that were predictive of the availability or unavailability of heroin reinforcement. Rats were trained to traverse a straight arm runway for a reinforcement consisting of a single 0.1 mg/kg intravenous infusion of heroin delivered upon entrance to the goal box. On each trial, one of two discriminative olfactory stimuli (orange and almond) was used: one which signaled the availability of heroin in the goal box (S+), and one which signaled its absence (S-). The effect of dopamine (DA) receptor antagonism on reinforcement and motivational processes was investigated by pretreating subjects with 0.0, 0.15 or 0.30 mg/kg of the DA receptor antagonist drug, haloperidol. Haloperidol had no effect on operant runway performance (i.e. goal time) in any condition. However, 24 h later, on the first post-treatment trial, those haloperidol animals that received heroin in the goal box on the previous trial (i.e. the S+ condition) ran reliably more slowly than subjects that received vehicle on the previous S+ trial. These results suggest that haloperidol does not affect the motivational properties of stimuli which predict the availability of heroin, while it does diminish the reinforcing effects of actually receiving heroin.

Analysis of Variance↗

PubMed1994

Hemispheric differences in image generation and use in the haptic modality.

Forty adults and 40 children, all right-handed, were presented with either of two series of six nonsense shapes to palpate: Those who were divided into sections by grid lines and thus provided categorical information or those who provided a whole shape and coordinate information that could be processed globally. Subjects were given an Input condition where they formed a mental representation of the shape while palpating the unseen tactual stimulus with either hand, followed by an Evaluation condition in which they attempted to solve the task by generating and using the previously stored image. Evaluation response times showed that the left hemisphere was significantly faster at generating images from categorically stored information. Neither hemisphere had an advantage when generating an image from globally stored information.

Adolescent↗

PubMed1994

Assessment of attention: relationship between psychological testing and information processing approaches.

Examined the relationship between the psychological testing and information processing approaches in assessing attention. Eighty-seven subjects (57 females, 30 males) undertook eight psychological tests of attention and a visual-spatial reaction-time task. Using the cognitive-correlate method (Posner & McLeod, 1982), it was found that three components of attention (viz., visual-motor scanning, sustained selective processing, and visual/auditory spanning) derived from the psychological tests could be significantly predicted by specific, yet different, combinations of six indices of information processing (mean reaction time (RT), mean movement time (MT), feature extraction, identification, response selection, and motor adjustment): (a) mean RT and mean MT were found to be the most important indices for predicting performance on visual-motor scanning; (b) the motor-adjustment stage was found to be the most important index for predicting performance on sustained selective processing; (c) the response-selection stage was found to be the most important index for predicting performance on visual/auditory spanning. These relationships are important for supporting the construct-related validity of the psychological tests of attention and for extending the generality and applicability of the RT task.

Adolescent↗

PubMed1994

Effects of closed-head injury on attentional processes: generality of Sternberg's additive factor method.

The present study examined the generality of Shum, McFarland, Bain, and Humphreys' (1990) findings that closed-head injury (CHI) selectively impairs different processes of attention (operationalized in terms of stages of information processing) depending on the severity of, and the time since, injury. The procedure of Shum et al. was based on Sternberg's additive factor method (AFM), with the mode of information processing involved being a physical-directional matching of visual stimuli. The present study followed a similar procedure except that a name-matching task was used. This task was administered to 16 first-year psychology students and two groups of CHI patients (viz., severe short-term (SS) and severe long-term (SL)) with matched control groups. The results obtained replicated the study by Shum in that the SS group was found to be impaired on the identification and response-selection stages of information processing whereas the SL group was found to be impaired only on the response-selection stage. The present study confirms that the AFM is not limited to one specific mode of information process and strengthens the validity of the conclusions made by Shum et al. regarding the effects of CHI on attention.

Adolescent↗

PubMed1992

Attentional deficits in head-injured children: an information processing analysis.

Attentional problems of closed head-injured (CHI) children were examined using an information processing (IP) approach. Based on Sternberg's (1969) additive factor method (AFM), the study examined attentional processes in terms of four stages and their corresponding task variables. A visual-spatial choice reaction-time task was undertaken with two groups of CHI children (severe and mild to moderate) and corresponding matched control groups. Results indicated that for this task both the CHI and the normal children exhibited a similar mode of linear, sequential information processing. It was found that the severe group was impaired not only in terms of slowed motor execution but also in terms of response selection. This group showed no impairment on the feature extraction, stimulus identification, and motor adjustment stages of processing. No evidence of impairment on any of the stages was found for the mild group. The utility of the AFM and implications of these findings are discussed with reference to CHI children and to neuropsychological assessment and rehabilitation.

Adolescent↗

PubMed1991

A simple dual-task study of laterality, sex-differences and handedness.

Nine-hundred and eighty-one right-handed and 55 left-handed subjects were required to tap with a pen for 10 secs between targets 6 cm apart whilst either saying nothing, reciting a tongue-twister or saying la-la. The numbers of dots produced in 10 secs in each condition were analysed. The right-handed group demonstrated the usually found degradation in their right-hand performance whilst reciting the meaningful words, but showed a lesser effect when saying la-la. Their left-handed performance was essentially unaffected. Absolutely no evidence for the presence of a sex difference in lateralization of language was found. The much smaller sample of left-handed subjects presented a complex picture of no significant effects, whether they were the sole left-handers in their family, or had other left-handed close relations.

Adolescent↗