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Biomedical subjects

K Matsuno

Publications and source records attributed to K Matsuno.

At least 361 records · Page 20Linked to original sources
PubMed1979

Distribution and role of lymph vessels of the bursa Fabricii.

The fine distribution of lymph vessels in the bursa of Fabricius and the efferent lymph vessels coming from the bursa were demonstrated. The lymph vessels never entered lymphoid follicles, whereas the blood vessels pierced the cortex of lymphoid follicles and formed a network at the boundary between the cortex and medulla of lymphoid follicles. The lymph vessels commenced in the immediate exterior of lymphoid follicles. A large number of lymphoid cells were found in the lumen of the lymph vessels. Migration of lymphoid cells from the cortex of lymphoid follicles to the lymph vessels was also observed. Therefore, it was assumed that the lymph vessels of the bursa are important in the transport of lymphoid cells from the bursa to the blood stream.

Animals↗
PubMed1979

Sex differences in the formation of germinal centres in the rat thymus.

Rats of inbred DA strain were given 20 intraperitoneal injections of typhoid-paratyphoid bacilli at 10 day intervals. Thymic lymph follicles with germinal centres were formed in females but not in males. However, orchidectomy permitted the formation of large numbers of thymic lymph follicles with germinal centres in males. The formation of lymph follicles with germinal centres in the thymus was not affected by ovariectomy. These results would appear to suggest an inhibitory role of androgens on the formation of thymic lymph follicles with germinal centres. In addition, large numbers of plasma cells, mast cells, and reticular cells, or macrophages with haemosiderin in their cytoplasm, appeared in the parenchma of the thymus in close association with the formation of thymic germinal centres.

Animals↗
PubMed1979

Amplification of plaque-forming cells in the spleen after intracloacal antigen stimulation in neonatal chicken.

Neonatal chickens were primed by multiple or a single injection with sheep red blood cells (SRBC) into the cloacal lumen and then were challenged by intravenous injection with the same antigen. Direct plaque-forming cells (PFC) in the spleen were markedly increased shortly after intracloacal priming. This enhancing effect was antigen specific and was abolished by surgical bursectomy 24 h after intracloacal priming. A similar effect was also found in mature adult chickens, although the degree of enhancement was far less than that found in neonatal chickens. These results suggest that a certain stage of B-cell differentiation in the bursa of Fabricius (BF) is regulated by antigenic stimulation.

Aging↗
PubMed1977

Lymph macrophages enter the germinal center of lymph nodes of guinea pigs.

To determine the fate of macrophages within the afferent lymph stream, the popliteal lymph nodes at various times (3 h to 6 months) after subcutaneous injection of india ink into the footpads of guinea pigs were examined. Two types of cells which had phagocytized india ink were observed in the germinal centers. A small number of type I phagocytes (engulfing india ink as small particles which were often found together with tingible bodies in their cytoplasm) were scattered through the germinal center. A large number of type II phagocytes (packed full of india ink) presented preferentially in the medullary portion of the germinal center, together with many pyroninophil lymphoblastoid cells. In the second experiment, the afferent lymphatics of the popliteal lymph node were ligated 15-20 min after india ink injection. Although the type I phagocytes were distributed as in the first experiment, the type II phagocytes were scanty. In the third experiment, the afferent lymphatics of the popliteal lymph node were ligated 7 days after india ink injection. The type II phagocytes disappeared rapidly from the germinal center, whereas the type I phagocytes remained and were not affected by ligature. These results suggest that the type I phagocytes are the fixed macrophages or tingible body macrophages in the germinal center, and that the type II phagocytes are the macrophages migrating from the peripheral tissues. It was also shown that many macrophages reaching the regional node via afferent lymphatics entered the germinal center through the medullary pole where the cap of small lymphocytes became thinner or disappeared.

Animals↗
PubMed1975

Appraisal of operative treatment for chronic pancreatitis. With special reference to side to side pancreaticojejunostomy.

A total of sixty-one operations were performed in sixty of seventy-one patients with chronic pancreatitis, with the following results. 1. The procedures used were side to side pancreaticojejunostomy in twenty-four patients, caudal pancreatectomy in ten, pancreaticoduodenectomy in six, total pancreatectomy in one, removal of pancreatic calculi in four, cystojejunostomy in two, biliary tract procedures in twelve, and drainage of pancreatic abscess in one. Operative fatality occurred in six patients, with fifty-four surviving operation. 2. Of fifty-three patients surviving operation (excluding the one who underwent only exploratory laparotomy), forty-seven (88 per cent) had relief of pain. With the exception of two patients with complicating cancer of the pancreas at the time of operation, of fifty-two patients surviving operation, thirty-nine (75 per cent) had satisfactory results at follow-up study. 3. Sixteen of twenty-four patients (66.7 per cent) undergoing side to side pancreaticojejunostomy had satisfactory follow-up results. 4. Comparison of pre- and postoperative body weight levels in twenty-one patients undergoing side to side pancreaticojejunostomy showed a postoperative loss of less than 10 per cent in seven, unchanged weight in two, and a gain in eleven patients, including five with more than 10 per cent gain. However, fat absorption examination in these patients showed no distinct postoperative improvement in digestion and absorption. 5. Histologic evidence in one patient at autopsy four years and eleven months after side to side pancreaticojejunostomy indicated improvement in fibrosis of the pancreas as compared with the findings at operation.

Adult↗