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Biomedical subjects

K Matsukuma

Publications and source records attributed to K Matsukuma.

At least 37 records · Page 2Linked to original sources
PubMed1989

Clinicopathologic study of squamous cell carcinoma of the ovary.

Clinicopathologic study was performed on 10 squamous cell carcinomas of the ovary. All four patients with stage II or III lesions had deteriorated within 1 year after the operation, and four of six patients with stage I lesions had survived over 5 years. Clinical findings of the patients with ovarian SCC, including age, chief complaint, clinical stage, and outcome of the patients, were similar to those of common epithelial cancer. The effectiveness of chemotherapy was not shown in this study. Histopathologic study revealed that squamous cell carcinoma may arise not only from epidermis, but also from squamous metaplastic epithelium of respiratory gland.

Adult↗
PubMed1989

Carcinoma of the uterine cervix with variegated histological patterns and calcitonin production.

This is a report of a calcitonin-producing cervical cancer with variegated histological patterns. The levels of calcitonin correlated with the clinical course. Multiple lung metastases were completely controlled by cisplatin/Adriamycin/cyclophasphamide combination chemotherapy, although only for a short period. Microscopically, the tumor showed dominant small cell carcinoma; however, it did show differentiation into large cell nonkeratinizing carcinoma, keratinizing carcinoma, adenocarcinoma, and possibly carcinoid. Ultrastructural study revealed a few dense core secretory granules. Multiple immunohistochemical studies were performed. It is presumed that the tumor originated from the totipotent, immature precursor cells in the cervix and differentiated into endocrine carcinoma, squamous cell cancer, and adenocarcinoma.

Aged↗
PubMed1989

Preoperative CT study of lymph nodes in cervical cancer--its correlation with histological findings.

A study was conducted to retrospectively evaluate the accuracy of abdominopelvic computed tomography (CT) in the diagnosis of paraaortic and pelvic lymph node metastases from carcinoma of the uterine cervix. Seventy patients with a diagnosis of invasive carcinoma of the cervix had preoperative CT of abdomen and pelvis and subsequently underwent a radical hysterectomy with pelvic lymph node dissection and paraaortic lymph node biopsy or an exploratory laparotomy with paraaortic lymph node biopsy. Five of six patients with metastatic paraaortic lymph nodes larger than 15 mm in diameter on the histologic slides were diagnosed by CT scan to have enlarged nodes. CT diagnosis was true-positive in five of seven patients with paraaortic lymph node metastases (71.4%). Two patients with false-positive paraaortic lymph nodes had clusters of small lymph nodes less than 10 mm in diameter on the histologic slides. In contrast, only a small number of the metastatic pelvic nodes were diagnosed by CT as enlarged nodes. CT diagnosis was true-positive in 5 of 11 sites with pelvic lymph node metastases (45.5%).

False Positive Reactions↗
PubMed1989

[Surgical management of pulmonary metastasis from carcinoma of the uterine cervix].

The present study was designed to evaluate the efficacy of surgical management of pulmonary metastasis from carcinoma of the uterine cervix. We saw 609 cases of carcinoma of the uterine cervix from 1979 to 1987, and during the same period also saw 110 cases of recurrent carcinoma of the uterine cervix. Fourteen of these 110 cases were identified as having pulmonary metastasis, and in 11 of 14 cases the recurrent tumors were limited to the lung. Seven of these 11 cases underwent pulmonary resection. Six of the 7 survived more than 2 years after pulmonary resection. Among them, 1 patient has survived more than 4 years, and 1 patient more than 8 years. The tumor cells were thought to metastasize to the lung through the vertebral venous plexus (Batson's plexus) which was suggested as a metastatic route by Thomford et al. in their report on recurrent colon cancer. As a result of this study, if the recurrent tumor is clinically limited to the lung in patients with recurrent carcinoma of the uterine cervix, they should be treated by surgical resection of the pulmonary tumor.

Adenocarcinoma↗
PubMed1989

[An evaluation of scalene lymph node metastasis in patients with gynecologic malignancies].

From 1981, through 1985, 90 patients with primary or recurrent gynecologic malignancies underwent a scalene lymph nodes (SLN) biopsy. Pelvic lymph nodes (PN) and paraaortic lymph nodes (PAN) also were examined for metastasis with CT, lymphography, and palpation or were biopsied after a laparotomy. Twenty-three of these 90 patients (25.6%) were found to have positive SLN. In 5 of these 23 (21.7%), their SLN had not been palpable on physical examination. All signs of PN, PAN and SLN were examined in 42 patients. Twenty-one of these 42 (50%) had positive PN, 14 (66.7%) had positive PAN, and 4 (28.6%) had positive SLN. Seven patients with negative PAN had no SLN metastasis. Of twenty-one patients with negative PN, 2 had positive PAN and none had an SLN metastasis. Thus, it has been concluded that an evaluation of SLN is important for the management of a gynecologic malignancy in patients with positive PAN.

Biopsy↗
PubMed1989

[Diagnosis and treatment of cervical dysplasia].

Between 1981 and 1986, 219 patients with cervical dysplasia were treated at the Kyushu University Hospital. All patients were diagnosed by cervical smear, colposcopy, and cervical biopsy and/or endo cervical curettage. They have been followed for more than one year (average 37 months). Of the 219 patients, 63 had mild dysplasia, 99 had moderate dysplasia, and 57 had severe dysplasia. One hundred and forty patients were treated with carbon dioxide laser. The remission rate was 95.0% after one treatment and 98.6% after two treatments. The laser therapy is effective, but a certain rate of recurrence is to be expected. Recently, 23 patients were treated with the cryotherapy and the remission rate was 83%.

Adult↗
PubMed1989

[Study on the treatment of malignant vulvar diseases].

During the past 15 years, 8 squamous cell carcinoma in situ and 21 invasive squamous cell carcinoma were treated in our department. Squamous cell carcinoma in situ was adequately treated by either wide local excision or CO2 laser vaporization. Radical vulvectomy was the main treatment modality in our department. Older patients tolerated well the surgery and had better outcome than those treated with radiotherapy alone. Histologically proven groin node metastasis was the risk factor to be overcome.

Adult↗
PubMed1989

[Evaluation of pre-radiotherapy staging laparotomy in cancer of the uterine cervix].

Staging laparotomy prior to radiotherapy was performed in 70 patients with cervix cancer. Biopsy proven para-aortic lymph node metastases were found in 16(22.9%) patients. Pelvic lymph node metastases were estimated by palpation at laparotomy and 36(51.4%) patients were thought to be positive. Other laparotomy findings were: invasion to the bladder muscle in 14, cul-de-sac metastasis in 10, adnexal metastasis in 2, other intrapelvic metastasis in 3, and positive peritoneal cytology in 9. At laparotomy several hemostatic clips were put on the serosal surfaces of the uterine wall in order to visualize the uterine contour in the localization X-ray films. By this method, six patients were proved to have uterine perforation at the time of small source insertion. Five-year survival rates for each clinical stage were: Stage I, 60%; II, 35.7%; III, 56.8%; and IV 0%. It seems that stage II is worse than stage III, but statistical differences were not found among stages I, II, and III. Three patients with para-aortic metastasis survived for more than four years. Late radiation complications occurred in 25(35.7%) of the patients. This complication rate was statistically higher than that of the patients who had not undergone staging laparotomy (21.1%).

Adult↗
PubMed1988

Alpha-fetoprotein producing endometrial adenocarcinoma: report of a case.

A case of endometrial adenocarcinoma which is producing alpha-fetoprotein (AFP) is described. AFP has been reported to be a tumor marker of gynecologic tumors, such as endodermal sinus tumor and embryonal carcinoma of the ovary. However, to our knowledge, there has been no report of AFP producing endometrial adenocarcinoma. The histologic study showed poorly differentiated adenocarcinoma of the endometrium and AFP was detected in the tumor cells by an immunoperoxidase-peroxidase-antiperoxidase technique.

Adenocarcinoma↗
PubMed1988

[Evaluation of paraaortic lymph node metastasis in patients with primary epithelial carcinoma of the ovary].

From 1979-1986, 110 patients with an ovarian cancer have been treated at Kyushu University Hospital. Sixty-eight of these patients with untreated primary adenocarcinoma of the ovary underwent a paraaortic lymph node (PAN) biopsy at the time of their initial surgery. Twenty-two of these 68 patients were found (32.4%) to have a positive PAN. Microscopic PAN metastases were present in 4 patients, who, macroscopically, seemed to have the disease confined to the pelvis. The incidence of a positive PAN was seen to correlate with the clinical stage and degree of differentiation of the primary tumor. Positive PANs were more frequent in cases of a serous rather than a mucinous carcinoma. All 5 patients with a metastatic adenocarcinoma originating from the stomach or the colon had a positive PAN. It thus has been concluded that a PAN evaluation is important for the management of ovarian cancer.

Adenocarcinoma↗
PubMed1988

[Evaluation of para-aortic lymph node metastases in patients with cervical cancer].

From 1979 to 1986, 355 patients with cervical cancer underwent paraaortic lymph node (PAN) biopsy before the start of initial treatment. Nineteen of these 355 patients (5.4%) had a positive PAN, and the percentage incidence of positive PAN in each clinical stage was as follow: stage Ib, 2.4%; IIa, 0%; IIb, 3.7%; IIIb, 19.0%; and IV, 20%. Eighteen of these 19 patients also had positive pelvic lymph nodes. Positive PANs were found to be more frequent in cases of an adenocarcinoma than in cases of squamous cancer. The palpation of the PANs seemed to be too insufficient to predict the metastasis. Patients with positive PAN who had received paraaortic irradiation survived longer than those who did not receive such treatment. It is concluded that the evaluation of the PAN is important for the management of a cervical cancer.

Adenocarcinoma↗
PubMed1988

[Superior vena cava syndrome associated with carcinoma of the uterine cervix--report of two cases].

Superior vena cava syndrome (SVCS) is a very rare complication in patients with a gynecologic malignancy. Only 4 cases have been reported in the English literature thus far and, to our knowledge, no such case has been reported in the Japanese literature. We have encountered two cases of SVCS in patients with cervical cancer. In case 1, the SVCS developed secondarily to a metastasis of the cervical cancer to the lungs and mediastinum. In case 2, the cause of the SVCS had been presumed to be due to metastatic cervical cancer, however on autopsy, it turned out to be due to a coexistent malignant lymphoma.

Carcinoma, Squamous Cell↗
PubMed1987

Short-term estrogen test for cytodiagnosis in postmenopausal women.

A short-term estrogen test was used to obtain a correct cytologic diagnosis in 73 patients with an equivocal atrophic cellular pattern. Overestimation in cytodiagnosis was markedly eliminated, and the correct cytologic diagnosis was made in 81% of the cell samples after the estrogen test. The purpose of this study was not only to confirm the usefulness of the short-term estrogen test, but also to observe the cytomorphologic changes before and after the test. Thick cytoplasm, vacuoles in the cytoplasm, and a distinct cell border increased, while the amorphous chromatin pattern was eliminated after the estrogen test. Maturation of atypical cells in cases of dysplasia, carcinoma in situ, and invasive squamous-cell carcinoma was investigated before and after the estrogen test. Although malignant cells were not influenced by estrogen, maturation of dysplastic cells was induced after the test.

Adult↗
PubMed1987

[Gliomatosis peritonei].

Gliomatosis peritonei, the miliary implants of mature glial tissues on the peritoneum or omentum, is a rare complication of solid ovarian teratoma. Our case is reported and 38 previously reported cases are reviewed. The grade of the primary tumors varied from grade 0 to grade 3. Only five cases were composed entirely of mature tissues. Five of the 39 patients died. Despite of varied therapy, the rest of the patients were alive from 3 months to 38 years later. Inspite of intraperitoneal implants, the prognosis in patients with these tumors is good, irrespective of the mode of therapy. On the basis of this study, we recommended a conservative therapy for the primary tumor and therapy for the implants is not required.

Adolescent↗
PubMed1987

[Evaluation of the efficacy of cisplatin-based chemotherapy in epithelial ovarian cancer; comparison with treatments employed before the cisplatin era].

Seventy-five patients with epithelial ovarian cancers received cisplatin-based chemotherapy as a post-surgical treatment in the 1980s. In the 1970s, fifty-eight patients received various treatments without cisplatin, which included radiotherapy, chemotherapy and their combination. In the patients with stage III disease, cisplatin-based chemotherapy achieved a median survival of 24 months, whereas other treatments employed in the 1970s achieved a median survival of 8 months. In the patients with early disease, however, cisplatin-based chemotherapy did not improve the survival. Since it is clear that cisplatin-based chemotherapy achieved an improved survival in the treatment of advanced epithelial ovarian cancer, it is concluded that this therapy is worth continuing until a more effective treatment is available.

Adult↗
PubMed1987

[An evaluation of para-aortic and pelvic lymph node metastases in patients with endometrial carcinoma].

During 1979-1986, 101 patients with an endometrial carcinoma were treated. Eighty-four of these patients underwent a para-aortic lymph node (PAN) biopsy at the time of their initial surgery, eight of whom (9.5%) were found to have a positive PAN. The incidence of positive PAN as per each clinical stage, was as follows: stage I, 2.0%; II, 11.5%; III, 50%; and, IV, 33.3%. Positive pelvic nodes were found in 19.2% of the patients, per the following stages: stage I, 6.1%; II, 32%; and, III & IV, 100%. This finding suggests that PAN metastasis occurs after the pelvic nodes are involved. A 5-year survival rate of approximately 50% is expected even in patients with a positive PAN. Thus our study concludes that an evaluation of para-aortic and pelvic lymph nodes is important for the management of an endometrial carcinoma.

Adult↗
PubMed1986

Prophylactic chemotherapy for hydatidiform mole. Five to 15 years follow-up.

The effectiveness of the prophylactic chemotherapy was evaluated in 420 patients with molar pregnancy. All patients were followed for 5 to 15 years after the evacuation. Twenty-two (7.5%) of 293 patients with prophylactic chemotherapy and 23 (18.1%) of 127 patients without prophylactic chemotherapy (control) developed secondary trophoblastic disease. The prophylactic chemotherapy could reduce the occurrence of secondary trophoblastic disease. In these secondary trophoblastic diseases, 5 (22.7%) of 22 patients in the prophylactic chemotherapy group and 5 (21.7%) of 23 in the control had metastatic trophoblastic disease. Choriocarcinoma after the molar pregnancy developed in two patients (0.7%) of the prophylactic chemotherapy group and two (1.6%) of the control. Prophylactic chemotherapy did not eliminate the occurrence of choriocarcinoma. The complication of the prophylactic chemotherapy was seen in 27.3% of the patients. Neither severe complication nor death were related to the toxicity.

Adolescent↗