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Biomedical subjects

K Matsui

Publications and source records attributed to K Matsui.

At least 577 records · Page 32Linked to original sources
PubMed1986

[Changes of ataxia, spontaneous movement and the cerebellar noradrenaline system with aging in ataxic mice].

Changes of cerebellar weight, spontaneous movement and ataxia with aging were investigated in Weaver and cytosine arabinoside-injected mice (Ara-C). In addition, changes of cerebellar NA and MHPG concentrations in both mice were measured by high performance liquid chromatography. Cerebellar weight increased with aging in both mice. Spontaneous movements in Weaver mice were not significantly changed, but Ara-C mice showed a decreasing tendency with aging. Ataxic gait improved with aging in Weaver mice, but not in Ara-C mice. With aging, cerebellar NA and MHPG concentrations were decreased in controls, but not in Ara-C mice. In Weaver mice, cerebellar MHPG concentration was decreased. These results suggest that NA turnover in ataxic mice is different from that in controls, but is not correlated closely with ataxia.

Aging↗
PubMed1986

Myosin light chain kinase and cyclic AMP-dependent protein kinase activities and calmodulin levels in placental and non-placental regions of the rabbit myometrium.

Myosin light chain kinase activity in the placental region of the rabbit myometrium on day 28 of gestation was 4.7 +/- 0.1 (mean +/- S.E.M.) nmol/min per mg protein, which was significantly higher than that (3.6 +/- 0.1 nmol/min per mg protein) in the non-placental region. The amount of calmodulin in the placental region was 4.2 +/- 0.1 micrograms/mg protein, which was significantly higher than that (3.2 +/- 0.1 micrograms/mg protein) in the non-placental region. In contrast, cyclic AMP-dependent protein kinase activities showed no difference between the two regions. These findings suggest that calcium- and calmodulin-dependent protein phosphorylation is activated mainly in the placental region, and uterine contractions can occur more strongly in this part than in the non-placental region. Such enzymatic phenomena may be related to the mechanism whereby the placenta separates from the myometrium after delivery of the fetus.

Animals↗
PubMed1986

Relaxant effects of pinacidil, nicorandil, hydralazine and nifedipine as studied in the porcine coronary artery and guinea-pig taenia coli.

Effects of pinacidil, a newly synthesized vasodilator, on contractures induced in the porcine coronary artery and the guinea-pig taenia coli were investigated in comparison with those of nicorandil, hydralazine and nifedipine. These four substances produced a dose-dependent relaxation of K+-induced contracture in the coronary artery, and the order of relaxant activity was nifedipine greater than pinacidil greater than hydralazine divided by nicorandil (IC50: 1.62 X 10(-8), 1.98 X 10(-4), 1.70 X 10(-3), 2.35 X 10(-3) M, respectively). Hydralazine inhibited the contraction induced by caffeine in a Ca2+-free (EGTA) high potassium medium in a concentration-dependent manner (IC50: 8.43 X 10(-3) M). Pinacidil and nicorandil produced a partial inhibition of this contraction (45.2, 22.3% inhibition at 10(-2) M, respectively), while nifedipine was ineffective. In the isolated guinea-pig taenia coli, these compounds caused a concentration-dependent relaxation. The relaxant action by pinacidil and nicorandil was more potent in spontaneously contracting preparation or in preparations contracted by 30 mM [K+]0 than in preparations contracted by 100 mM [K+]0, while the reverse was true with nifedipine. Hydralazine was effective at similar concentrations on these three types of contraction. From these findings it was inferred that the smooth muscle relaxing-action of pinacidil and nicorandil was ascribable to the inhibitory action on the spontaneous spike activities of the surface membrane. Inhibition of the mobilization of calcium from intracellular store sites may play some role.

Animals↗
PubMed1986

Alternating non-cross resistant chemotherapy for small cell lung cancer.

After stratification for the extent of disease, previously untreated patients with small cell lung cancer randomized to receive therapy with the four-drug combination of cyclophosphamide, oncovin, nimustine hydrochloride (ACNU), and procarbazine (CONP) every four weeks (continuous regimen) or to receive CONP alternating with the three-drug combination of etoposide (VP-16), adriamycin and cisplatin (VAD) at four-week intervals (alternating regimen). Sixty-nine patients were entered in the study. Of 34 evaluable patients receiving the continuous regimen, six (17.6%) achieved complete response (CR) and 16 (47.1%) achieved partial response (PR). Of 31 evaluable patients receiving the alternating regimen, 10 (32.3%) achieved CR, and 16 (51.6%) achieved PR. There was a tendency in favor of the alternating regimen in CR and over-all response rates (0.05 less than p less than 0.1). There were no significant differences between the regimens in response duration or survival. The projected median survival times were 9.2 months and 9.4 months for the continuous and alternating regimens, respectively. One patient receiving the continuous regimen and three receiving the alternating regimen have been living for more than two years. The major toxicity was myelosuppression in both regimens. One patient died of hemorrhage due to thrombocytopenia during induction with CONP, and one patient died of cisplatin-induced renal failure. We conclude that alternating non-cross resistant chemotherapy leads to improved CR and response rates, but does not improve survival.

Adult↗
PubMed1986

[Effect of DN-1417 on ataxia in Rolling mouse Nagoya and Staggerer mouse in comparison with the effect of TRH].

The behavioral effects of thyrotropin-releasing hormone (TRH) and a TRH analogue, DN-1417 (butyrolactone-carbonyl-L-histidyl-L-prolinamide citrate) on the ataxia of Rolling mouse Nagoya and Staggerer mouse were examined using open-field methods. The ataxic gaits improved after injection of TRH (25 mg/kg, ip) and DN-1417 (5.25 mg/kg ip), compared with injection of saline. As a whole, the improving effect of DN-1417 persisted about 2 or more times as long in duration as that of TRH.

Animals↗
PubMed1986

Fetal blood velocity waveforms in uncomplicated pregnancy.

Umbilical artery velocity waves were measured in fetuses from 94 normal pregnant women. In all, 183 determinations were carried out from the 14th to the 40th week of gestation. A combination of pulsed echo and real-time scanning was used to obtain blood waveforms from the umbilical arteries. The umbilical artery velocity wave can be readily differentiated from other fetal signals by its pattern. The systolic peak of the velocity wave was divided by the end diastolic value, thereby giving an S/D ratio. The S/D ratio in normal pregnancy declined from 7.6 to 2.0 from 14 to 40 weeks. Analysis of these waveforms indicated that the placenta is an organ of low vascular resistance and that placental resistance to blood flow declines with advancing gestational age in normal pregnancy. The umbilical artery S/D ratio provides a new and non-invasive marker of fetoplacental blood flow resistance.

Blood Flow Velocity↗
PubMed1986

Monoclonal autoantibodies in Heymann nephritis.

We have developed hybridoma cell lines, each of which secretes a monoclonal antibody (MoAb) to rat renal and hepatic tissue antigens, from Lewis rat with Heymann's nephritis. Three antibodies bind to the brush border of proximal tubular epithelium (BB), one in a fine net-like pattern (no. 3-11), another one in a coarse granular pattern (no. 1-8) and the third one in a typical pattern (no. 3-9). Three antibodies bind to glomerulus in characteristic patterns but not to BB. After repeated intravenous injections of MoAb (no. 3-11), granular mesangial deposits of rat IgG were observed and of MoAb (no. 1-8), fine granular deposition along capillary walls. These monoclonal autoantibodies should be of value in research on the mechanism of autoimmune membranous nephropathy.

Animals↗
PubMed1986

Lymphoscintigraphy in patients with lymphedema. A new approach using intradermal injections of technetium-99m human serum albumin.

Forty cases were examined by a new lymphoscintigraphic approach using intradermal injections of Tc-99m human serum albumin (HSA). Thirty-three patients had lymphedema due to the metastases of a malignant tumor and/or the dissection of lymph nodes. The others were control patients without lymphedema. With the assistance of a computer, sequential images and time-activity curves of tracer activity in the lymph nodes and the soft tissue were obtained at 30 minutes after injection. An image of the axillary or inguinal lymph nodes was identified 2-6 minutes after injection in control cases. Four main abnormal findings, the delayed appearance of radioactivity and interruption of the lymphatic system, the collateral pathways, and the retrograde lymphatic flow were observed clearly, as was the nonvisualization of the lymph nodes. These abnormalities were observed in a high percentage of patients with moderate lymphedema, as compared with a low percentage of patients with slight lymphedema. The collateral pathways could not be observed in patients with severe lymphedema. Imaging with Tc-99m HSA was considered to be more useful than other techniques, including radiocolloid lymphoscintigraphy, for examining patients with lymphedema.

Adult↗
PubMed1986

[A randomized control study of the antiemetic efficacy of betamethasone versus methylprednisolone].

A randomized control study of the antiemetic activity of betamethasone (B) vs. methylprednisolone (MP) was carried out. Fifty-six patients receiving CDDP (60 mg/m2-80 mg/m2) were entered. B (8 mg/body on day 1, 4 mg/body on days 2 and 3) was administered intravenously in 18 patients, and MP (1,000 mg/body on day 1, 500 mg/body on days 2 and 3) was administered intravenously in 19 patients. Severe vomiting occurred in 5 of the 19 (26.3%) with MP, 10 of the 18 (55.6%) with B, and 11 of 19 (57.9%) controls. Severe nausea occurred in 3 of the 19 (15.8%) with MP, 6 of the 18 (33.3%) with B, and 5 of the 19 (26.3%) controls. Methylprednisolone was thus considered effective (P less than 0.05) for CDDP-induced emesis.

Betamethasone↗