Search PubMed⌕ Search

Biomedical subjects

K Masuda

Publications and source records attributed to K Masuda.

At least 955 records · Page 53Linked to original sources
PubMedDate not supplied

Radiotherapy for localized relapse in patients with non-Hodgkin's lymphoma: a preliminary report.

PURPOSE: To evaluate the usefulness of radiotherapy for relapse of non-Hodgkin's lymphoma (NHL) at a localized site. METHODS: Of 79 patients with relapsed intermediate- or high-grade NHL, 13 patients (16.5%) with a localized relapse were analyzed retrospectively. RESULTS: Five patients were treated with radiotherapy alone and eight were treated with radiotherapy plus conventional chemotherapy (CHOP or other combinations). Radiotherapy was delivered to the involved field to a mean total dose of 34.1 Gy (range, 21-51 Gy). The 5-year overall and disease-free survival rates were 80.2% and 76.2%, respectively. Four patients relapsed subsequently. After further salvage therapy, two patients died of NHL and two were alive without active disease. CONCLUSION: Radiotherapy may be an important component of treatment for selected patients with NHL who relapse at a localized site.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Application of liver transplantation for familial amyloid polyneuropathy combined with Crohn's disease.

We describe the case of a 31-year-old Japanese man with familial amyloid polyneuropathy combined with Crohn's disease, who underwent living-related orthotopic liver transplantation. Although he had a 2-year history of alternating constipation/diarrhea, his bowel symptoms exacerbated severely during the period he was in our ward for pretransplant evaluation. Small bowel barium examination and gastroduodenal endoscopy showed typical features of Crohn's disease. He was diagnosed as having active Crohn's disease, and the scheduled living-related orthotopic liver transplantation was postponed. After controlling the active disease with conservative therapy for two months, he underwent living-related orthotopic liver transplantation using a graft of the left lobe from his father. Postoperative medication consisted of azathioprine, aminosalicylates, tacrolimus and steroids. His postoperative course was uneventful, and he was discharged from hospital on the 25th postoperative day. Pre- and postoperative transplant management of patients with Crohn's disease is also discussed, because it influences the clinical course of inflammatory bowel diseases.

Adult↗
PubMedDate not supplied

Carboplatin AUC and gamma-glutamylcysteine synthetase gene expression in peripheral mononuclear cells of lung cancer patients.

BACKGROUND: To investigate the association between glutathione-related enzymes and carboplatin (CBDCA) dose, we examined gene expression levels for both subunits of gamma-glutamylcysteine synthetase (heavy; gamma-GCSh, light; gamma-GCS1) in peripheral mononuclear cells (PMN) of lung cancer patients before and after CBDCA administration. MATERIALS AND METHODS: PMN and plasma samples were obtained from 10 advanced non-small lung cancer patients before and after CBDCA administration. We analyzed the gene expression levels by reverse transcription-polymerase chain reaction. RESULTS: Gamma-GCSh expression levels in PMN increased within 24 hours after CBDCA administration, whereas gamma-GCS1 expression levels did not. However, the actual area under the concentration curve (AUC) of CBDCA did not correlate with gamma-GCSh expression at 24 hours or the increased ratio of gamma-GCSh expression in PMN. CONCLUSION: Expression of gamma-GCSh is induced by CBDCA, however, CBDCA AUC is not a determinant for the increased expression levels of gamma-GCSh in PMN.

Antineoplastic Agents↗
PubMedDate not supplied

Uterine leiomyoma: correlation between signal intensity on magnetic resonance imaging and pathologic characteristics.

To correlate the signal intensity of uterine leiomyoma with its pathologic characteristics, with particular emphasis on the fibrous component, 33 magnetic resonance (MR) examinations that revealed 93 leiomyomas were prospectively studied. All patients were imaged in axial and sagittal planes with different spin-echo pulse sequences to obtain T1-, T2-weighted, and proton density images. Nondegenerative leiomyomas (n = 62) showing a homogeneous signal of low intensity, and degenerative leiomyomas (n = 31) with a heterogeneous signal of variable intensity on T2-weighted images could be correlated. Histopathological assessment of fiber constitution and degeneration, and MR intensity were interpreted by independent observers. There was excellent accord between the averages for MR intensity, T2 relaxation time and fiber content, although the intensity values in each fiber grade showed a wide range. The greater the fiber content the lower the MR intensity on T2-weighted images, and the shorter the T2 relaxation time (p < 0.0001). In addition, the manner in which fiber distribution affected MR appearance was also elucidated. These data contribute guidelines for precise tissue differentiation of myogenic tumors on MR images, and for MR imaging tissue diagnosis of any lesion with a considerable fibrous element.

Adult↗
PubMedDate not supplied

Atypical arteriographic features of myositis ossificans circumscripta (MOC).

Earlier reports on the angiographic features of MOC concluded that there may be hypervascularity and tumor stain but no A-V shunting, pooling, or vessel amputation as a result of the lesion. However, our cases demonstrated A-V shunting in MOC, and showed that the vascularity of this lesion can closely mimic that of malignant neoplasms. Therefore, the possibility of MOC should not be excluded because of the presence of A-V shunts or "tumor vessels" in suspected MOC lesion on plain radiography. These points are underscored by the findings in two MOC patients, whose cases are described.

Adult↗
PubMedDate not supplied

Diffusely calcified renal cell carcinoma: CT features.

Calcifications of renal masses are common. They are usually dense, partial, small, punctate, and linear opacities. Diffuse calcification is an extremely rare feature of renal masses. Generally, calcified renal cell carcinomas are hypovascular, with calcifications in the interstitium, and they also contain fibrotic capsules, necrotic areas, or hyalinization. We recently observed a renal neoplasm with diffuse calcification on CT and intermediate vascularity on angiography, which was diagnosed histologically as renal cell carcinoma, clear cell type. Interestingly, there were numerous calcific deposits within the tumor cells.

Adult↗
PubMedDate not supplied

MR imaging of pituitary dwarfism.

The purpose of this study was to determine whether the MR findings of idiopathic pituitary dwarfism correlated with a clinical history of perinatal abnormalities and abnormal levels of pituitary hormones. MR examinations of 18 patients with pituitary dwarfism were performed; these patients were divided into two groups: those with ectopic posterior lobes (group 1) and those with normal posterior lobes (group 2). Among the seven patients in group 1, MR showed hyperintense signal at the median eminence of the hypothalamus, which was regarded as the ectopic posterior lobe of the pituitary gland. The mean anteroposterior length and height of the pituitary gland in group 1 patients were significantly smaller than those dimensions in the normal control group; the pituitary stalk was not detected in three of seven patients. Six of seven patients were products of breech presentation with perinatal asphyxia. The peak serum growth hormone level was less than 5 ng/ml when assessed by insulin-induced hypoglycemia or the clonidine test. MR findings in the 11 patients with pituitary dwarfism and normal posterior lobes were normal except that the mean size of the pituitary gland was slightly smaller than that of normal controls. The clinical history of these patients was normal except for perinatal asphyxia in one case. Our findings in patients with pituitary dwarfism, with or without an ectopic posterior pituitary lobe suggest that the ectopic lobe, visualized as a bright spot at the median eminence of the hypothalamus, may be common when pituitary dwarfism follows perinatal anoxic/ischemic episodes.

Adolescent↗
PubMedDate not supplied

Chronic liver disease: value of volumetry of liver and spleen with computed tomography.

Volumetric comparisons of portions of liver and spleen were performed in patients with chronic liver diseases to determine their diagnostic value. Volumetric ratios of liver and spleen were determined by CT examination in 34 normal subjects and 125 consecutive patients with histologically proved liver cirrhosis, chronic active hepatitis, chronic persistent hepatitis, acute hepatitis, or fatty liver. Ratios of caudate lobe, spleen, and lateral segment of the left lobe of the liver to the remainder of the liver, right lobe and medial segment of the left lobe (RL+LM), were calculated. The product of caudate lobe/RL+LM and spleen/RL+LM was of value in differentiating liver cirrhosis from other liver disease, with a sensitivity of 60%, specificity of 98%, and accuracy of 86%. The same ratios differentiated liver cirrhosis and chronic active hepatitis from other liver diseases with a sensitivity of 79%, specificity of 100%, and accuracy of 90%. Volumetric ratio measurements are useful in the diagnosis of cirrhosis and chronic active hepatitis.

Acute Disease↗
PubMedDate not supplied

Gd-DTPA administered MR imaging of intracranial mass lesions: a comparison with CT and precontrast MR.

Magnetic resonance (MR) images of 13 intracranial mass lesions taken with the intravenous administration of gadolinium-DTPA were evaluated in comparison with precontrast computed tomography (CT), postcontrast CT, and precontrast MR. In the MR images taken with Gd-DTPA, tumor delineation improved in eight of 13 cases (62%) in comparison with precontrast MR images, and in seven of 13 cases (54%) in comparison with the overall evaluation of precontrast CT, postcontrast CT, and precontrast MR images. Tumor demarcation was unchanged in the remaining cases; no deterioration was observed with Gd-DTPA administration. MR imaging with Gd-DTPA should be performed to better evaluate the extent of intracranial mass lesions and to provide additional information.

Adult↗
PubMedDate not supplied

Angiographic observations in idiopathic trigeminal neuralgia.

Twenty-four patients with idiopathic trigeminal neuralgia were treated by neurovascular decompression surgery. All patients underwent preoperative vertebral angiography. After surgery, the vertebral angiograms of these patients were retrospectively reviewed. In 23 of the 24 patients, the superior cerebellar artery (SCA) and/or the anterior inferior cerebellar artery (AICA) compressed the trigeminal nerve. In the remaining case, no such compression by vessels was observed. On review of the angiograms, most of the compressing arteries, and the sites and numbers of compression points could be identified. Most of the caudal points of the SCAs which did not compress the trigeminal nerve were located higher than the compression points of the SCAs. It was therefore concluded that vertebral angiography is useful in the preoperative evaluation of compressing arteries. Since superimposition of arteries could be avoided, the straight AP projection was the most valuable of the three projections employed.

Adult↗
PubMedDate not supplied

Radiosensitivity of irradiated mouse skin to a second course of single and multifractionated irradiation. I. Early skin reaction.

Six or 12 months after a single or multifractionated gamma ray irradiation of the skin from the hind legs of mice, the response of the skin to the test dose in single or multi-fractionated (4-16) exposures was studied, using an early skin reaction as an endpoint. The pre-irradiated skin was relatively radioresistant compared to the previously untreated control skin in either dorsal or ventral sides of the legs. The variation in the skin sensitivity depending on the site of irradiation is also discussed for the pretreated and the untreated skin.

Animals↗
PubMedDate not supplied

Hepatocellular carcinoma with pyrexia: report of a case.

Reported here is a case of an unusual type of hepatocellular carcinoma (HCC). Since this patient with liver mass exhibited continuous pyrexia, an inflammatory pseudotumor or abscess was strongly suspected. Two-phased incremental CT, MR with and without Gd-DTPA administration, and angiography demonstrated peripheral enhancement of the hepatic mass. Histologically, the tumor proved to be HCC with sarcomatoid degeneration. When one encounters a patient with a mass clinically and radiologically mimicking an inflammatory pseudotumor or an abscess, poorly differentiated HCC with sarcomatoid degeneration should be suspected.

Aged↗
PubMedDate not supplied

Well-differentiated hepatocellular carcinoma: isointense to liver parenchyma on superparamagnetic iron oxide-enhanced MR.

We present a patient with hepatocellular carcinoma that was identified on precontrast MR and became isointense to liver parenchyma after the intravenous administration of superparamagnetic iron oxide. The tumor was well-differentiated hepatocellular carcinoma and contained approximately the same number of Kupffer cells as liver parenchyma on pathological examination. Our case suggests that superparamagnetic iron oxide may give confusing results if the hepatic mass, e.g., hepatocellular carcinoma, contains Kupffer cells.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Microbiological evaluation of a newly designed dental air-turbine handpiece for anti-cross contaminations.

The effectiveness of a newly developed anti-cross contamination device for a dental air-turbine handpiece was tested. The handpiece with or without the anti-cross contamination device was contaminated with two bacterial strains, Staphylococcus aureus and Streptococcus mutans, as well as two bacteriophage strains, T2 and MS2. After contamination with these microorganisms, the handpieces were disinfected with glutaraldehyde or replaced with newly autoclaved ones. Residual microorganisms inside the handpiece or an air/water supply hose line were collected and counted after overnight cultivation. The anti-cross contamination device effectively reduced the contamination level of an air-turbine handpiece to that of the negative control. No microbial contamination in the air/water supply hose line was detected with this device.

Air Microbiology↗
PubMedDate not supplied

Histopathologic correlation of two-phased dynamic incremental CT in hepatocellular carcinomas using multivariate analysis.

In order to grade pathologic factors that influence CT findings in hepatocellular carcinomas (HCCs), the CT-pathologic correlation was assessed statistically using univariate and multivariate analyses of 75 lesions. CT findings of early and delayed phase scans using two-phase dynamic incremental CT (TDICT) were compared with pathologic findings in resected specimens to calculate a category score for each pathologic finding. According to category scores, histopathologic differentiation and growth pattern were the major determinants of tumor density. Determinants of the internal structure of tumors were cytological variants, histologic differentiation, and macroscopic classification, in that order. Macroscopic classification, histologic differentiation, fibrous capsule characteristics, and growth pattern were important in descending order for tumor margins. Histologic differentiation was the most important factor for determining TDICT findings in HCCs. The CT findings were modified by parenchymal liver disease and cytologic variants.

Adult↗