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Biomedical subjects

K Mase

Publications and source records attributed to K Mase.

At least 37 records · Page 2Linked to original sources
PubMed1996

[Anesthetic management of a pediatric patient with Cornelia de Lange syndrome].

We did anesthetic management on a pediatric patient with Cornelia de Lange syndrome presenting a peculiar look, variable physical deformities, and some growth and mental retardations. An 8-year-old male patient was scheduled for inguinal hernioplasty under general anesthesia. This patient had been suffering from dehydration for apodeisis and self-destructive tendency due to psychologic stress. Anesthesia was induced and maintained with sevoflurane and N2O in oxygen. The area of skin incision was infiltrated with 0.25 % bupivacaine for the purpose of post-operative analgesia, and as a result, psychologically and physically stable condition was obtained during post-operative periods. It is necessary to understand not only the patient's physical conditions but also mental ones in order to make the anesthetic management safer and more satisfactory.

Analgesia↗
PubMed1995

In Situ Detection of Surface SiH(n) in Synchrotron-Radiation-Induced Chemical Vapor Deposition of a-Si on an SiO(2) Substrate.

The sensitivity and linearity of infrared reflection absorption spectroscopy (IRAS) has been significantly improved by using a buried-metal-layer (BML) substrate having an SiO(2)(15 nm)/Al(200 nm)/Si(100) structure, instead of a plain Si(100) substrate. By applying this BML-IRAS technique to the in situ observation of synchrotron-radiation-induced chemical vapor deposition of amorphous Si (a-Si) on an SiO(2) surface using Si(2)H(6) gas, the vibrational spectra of surface SiH(n) species in this reaction system have been observed for the first time with sufficient sensitivity for submonolayer coverage. The main silicon hydride species after deposition at 423 K are surface SiH(2) and SiH. Surface SiH(3) and SiH(2) are observed to be easily decomposed by synchrotron radiation irradiation. The decomposition rate of SiH by synchrotron radiation irradiation is much slower than those of SiH(2) and SiH(3).

Journal Article↗
PubMed1995

[Criteria of limited operation for bronchial carcinoid].

The purpose of this study is to establish criteria of limited operation for bronchial carcinoid. Ten cases surgically treated in our hospital and 47 cases reported in Japan from 1981 to 1992 were examined. Thirty-nine cases had typical carcinoid tumor and 18 had atypical. Limited operation, such as pulmonary segmentectomy, wedge resection or partial resection, was performed in 12 cases. In these, all patients of typical type were alive except for a case died of other disease. However, two patients of atypical type died of distant metastasis of the tumor. No lymph node metastasis was revealed in all cases of typical type. On the contrary, in cases of atypical type, six had n1 and two had n2 disease. Moreover, two cases with n1 disease had pulmonary metastasis. Therefore, patients with typical bronchial carcinoid can be cured by limited operation, but radical operation should be indicated for atypical bronchial carcinoid.

Adult↗
PubMed1994

[New endoscopic laser treatment for unilateral vocal cord paralysis after pulmonary resection].

In two patients who had developed aspiration due to left recurrent laryngeal nerve injury during radical resection for lung cancer, low power Nd:YAG laser irradiation of the paralyzed vocal cord was performed through a bronchofiberscope. With irradiation, the paralyzed vocal cords of both patients swelled and became fixed at the median portion of the glottis. Thereafter, aspiration disappeared. Thus, this new application of Nd:YAG laser irradiation is apparently quite useful in treating aspiration due to unilateral vocal cord paralysis immediately after pulmonary resection.

Bronchoscopy↗
PubMed1993

[A case of coronary artery bypass grafting (CABG) with acquired tracheobronchomalacia].

Acquired tracheobronchomalacia is often overlooked because the symptoms are similar to those of chronic obstructive lung disease. A 55-year-old man underwent an emergency CABG because of unstable angina pectoris. CABG was performed uneventfully. On the third day after operation, severe cough and dyspnea were persisted, followed by the episode of ventricular fibilliration. Cardiopulmonary resuscitation was necessary. CT scan of the chest showed crescent narrow deformity from the lower trachea to the right main bronchus. Bronchoscopic examination revealed 90% stenosis of the trachea during coughing, and edematous tracheal mucosa. Acquired tracheobronchomalacia is an illness of the middle-aged and the elderly and tends to be progressive. Recently, because the patients for CABG have become older, tracheobronchomalacia should be taken into consideration.

Angina, Unstable↗
PubMed1992

[Evaluation of platelet aggregation test by grading curve].

In order to standardize the platelet aggregation test, we used the grading curve (GC) produced by plotting four concentrations (0.5, 1.0, 2.0 and 4.0 microM) of ADP and four concentrations (0.25, 0.5, 1.0 and 2.0 micrograms/ml) of collagen, which are aggregation inducers, along the horizontal axis and plotting their individual rates (%) of aggregation 5 minutes after administration, along the longitudinal axis. The degree of platelet aggregation was classified in 6 stages (Types III, II, I, 0, -I and -II), ranging from marked increase to marked decrease, according to the GC of ADP aggregation in healthy subjects. Type I or 0 ADP aggregation was observed in 78% of the subjects, and Type I collagen aggregation was observed in about 50% of the subjects, whereas patients with cerebral infarction showed distinct increases in Type III and II aggregations of both ADP and collagen. In most patients who were treated with antiplatelet drugs, the aggregation were Type 0, -I or -II. The concentration of inducer, which corresponded to the maximum 50% value of the GC (Max 50) was significantly correlated with the minimum concentration (threshold concentration) in ADP aggregation, at which secondary aggregation was induced even if it was reversible, and with the minimum concentration (threshold concentration) in collagen aggregation, at which the aggregation rate 5 minutes after administration increased to 50% or higher. The GC of platelet aggregation seemed to enable easy determination of the degree of aggregation, and was also considered to be useful for monitoring platelet aggregation during the administration of antiplatelet drugs.

Adult↗
PubMed1992

[Clinical and preclinical pharmacology of KC-764, a novel antiplatelet agent].

Preclinical pharmacological studies showed that KC-764 was more potent and more selective in inhibiting platelet aggregation than aspirin. The concentration of KC-764 for inhibiting PGI2 production in the aorta was 70 times higher than that for inhibiting TXA2 in platelets. Antiplatelet action of KC-764 was augmented by plasma components. This augmentation by plasma may lead to selective antiplatelet activity. KC-764 has been investigated for platelet function in patients with chronic cerebral infarction. KC-764 at 10, 20 and 40 mg b i d, inhibited platelet aggregation induced by arachidonic acid, collagen, and ADP, and its potency was almost equal to aspirin at 100-330 mg daily. Plasma TXB2 levels were markedly depressed by KC-764 but plasma 6-keto-PGF1 alpha levels were not influenced. On the contrary, aspirin depressed both plasma prostanoids. These findings suggest that KC-764 can overcome the 'aspirin dilemma'.

Adenosine Diphosphate↗
PubMed1991

[Neurological sequelae caused by surgical procedures during adenoidectomy under anesthesia].

A five-year old boy with good risk was anesthetized with nitrous-oxide and halothane under orotracheal intubation for adenoidectomy and tubing of bilateral middle-ear cavities. Patient was on supine position with extension of neck. A mouth-gag was applied and the pharynx was packed with gauze. After long unskilled surgical procedures, severe neurological complications which were initiated with severe arrhythmias and followed by signs of paralysis of bilateral IX, X, XI, XII cranial nerves at their nuclei in medulla oblongata, were observed during the post-anesthetic period. The patient was saved with neurological sequelae of the cranial nerves and is alive after 6 years from the incident. The causes of this complications were discussed.

Adenoidectomy↗
PubMed1989

Generalized sarcoidlike granulomas with systemic angiitis, crescentic glomerulonephritis, and pulmonary hemorrhage. Report of an autopsy case.

A 19-year-old woman showed rapidly progressive renal and respiratory failure and died after a short clinical course. The autopsy revealed that death was due to crescentic glomerulonephritis and pulmonary hemorrhage. The intrathoracic lymph nodes, lungs, kidneys, and other organs contained numerous epithelioid granulomas, some of which had foci of central coagulative necrosis. The aorta, its major branches, and small- to medium-sized vessels of various organs also had multiple areas of granulomatous angiitis. This is, to our knowledge, the first report of such autopsy findings. A discussion of the etiopathogenesis of the disease is presented.

Adult↗