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Biomedical subjects

K Marumo

Publications and source records attributed to K Marumo.

88 records · Page 5Linked to original sources
PubMed1984

Human lymphoblastoid interferon therapy for advanced renal cell carcinoma.

Antitumor activity of human lymphoblastoid interferon (HLBI) in advanced renal cell carcinoma was studied. Intramuscular injection at a dose of 3 X 10(6) IU was given daily to 18 patients, including 14 patients who had undergone nephrectomy and 4 patients who had not undergone the procedure. One patient (5.6%) showed complete remission; 2 patients (11.1%) minor remission, 8 patients (44.4%) stable disease, and 7 patients (38.9%) progression. Three responders were the patients who had had nephrectomy, and whose metastatic sites were lung. Tumor responses were observed in patients with renal cell carcinoma of clear cell type or mixed type of clear cells and granular cells. We concluded that interferon has a potential antitumor activity in selected patients with advanced renal cell carcinoma.

Adult↗
PubMed1984

Plasma responses and pancreatic content of pancreatic polypeptide, glucagon and insulin in alloxan diabetic and normal dogs and their immunohistological studies.

Responses of plasma pancreatic polypeptide (PP), glucagon (IRG) and insulin (IRI) after administration of beef soup were studied in normal and alloxan diabetic dogs and their regional content in the pancreas was determined in normal and four or twelve weeks alloxan diabetic dogs. Plasma PP levels of the diabetic dogs were significantly higher than those of the normal dogs and they increased after beef soup administration in both groups. Higher levels of IRG were also found in the diabetic dogs, although IRG increased significantly after beef soup ingestion only in normal dogs. The amounts of PP in the pancreas of normal and diabetic dogs were greatest at the uncinate process, followed in order by the head, body and tail. The IRG content in the pancreas was highest at the tail and lowest at the uncinate process in both dogs. The differences in both PP and IRG in pancreas between normal and diabetic dogs kept in a poor metabolic state for one or three months were not significant in any region of the pancreas. Immunocytochemical studies also suggested these findings. These results show that, irrespective of high plasma levels of PP and IRG in the diabetic dogs, their levels in the pancreas did not change significantly as also indicated by histological studies.

Animals↗
PubMed1984

Plasma responses of pancreatic polypeptide, glucagon and insulin in normal and alloxan diabetic dogs, and their regional levels in the pancreas.

The plasma responses of pancreatic polypeptide (PP), glucagon (IRG) and insulin (IRI) after administration of beef soup were studied in normal and alloxan diabetic dogs kept in a poor metabolic state for 4 weeks, and their regional levels in the pancreas were determined and compared at the uncinate process, head, body and tail. The plasma PP levels of the diabetic dogs were significantly higher than those of the normal dogs and they increased after beef soup administration in both groups. The plasma IRG levels did not change significantly after beef soup administration in either group, but significantly high levels were found in the diabetic dogs. The IRI content in the normal dog pancreas was highest at the tail, followed in order by the body, head and uncinate process, and was decreased to about one-tenth to one-fortieth in the alloxan diabetic dogs. On the other hand, the amounts of PP in the pancreas of both normal and diabetic dogs were greatest at the uncinate process, followed in order by the head, body and tail. In an inverse relationship with the PP findings, the IRG content in the pancreas was highest at the tail and lowest at the uncinate process in both kinds of dogs. The differences in both PP and IRG between diabetic and normal dogs were generally not significant. These results show that irrespective of the high plasma levels of PP and IRG in the diabetic dogs, their levels in the pancreas did not change significantly.

Animals↗
PubMed1983

Plasma amino acid levels in hyperosmolar nonketotic diabetic coma.

The plasma amino acid levels in five patients with hyperosmolar nonketotic diabetic coma and in seven normal subjects were analysed. In the patients with hyperosmolar nonketotic diabetic coma, total amino acids were generally low, especially, the concentrations and the molar ratios of arginine, taurine and serine were significantly low, and ornithine decreased only at the concentration. The level of phenylalanine increased both at the concentration and the molar ratio, and tyrosine did only at the molar ratio. The significance of such changes in the plasma is discussed in relation to diabetic ketoacidosis or lactic acidosis.

Amino Acids↗
PubMed1983

Pancreatic polypeptide and insulin contents in diabetic and nondiabetic human pancreas and their relationship to the stability of the fasting serum glucose.

The amounts of insulin and pancreatic polypeptide (PP) in twenty four autopsied diabetic and nineteen nondiabetic human pancreases were determined and their relationship to the stability of the fasting serum glucose level was investigated. The PP content of the tail of the pancreas in diabetic and nondiabetic subjects was 9.55 +/- 2.41 and 7.71 +/- 1.52 micrograms/g pancreas, and that of the head of the pancreas was 16.86 +/- 5.51 and 15.82 +/- 5.38 micrograms/g, respectively. No significant differences in content were found between diabetic and nondiabetic pancreases. The PP content of the head pancreas of some diabetics and nondiabetics was higher than that of the tail. The insulin content of the tail of the diabetic pancreas was lower than that of the nondiabetic pancreas. In those diabetics where there was less than 0.5 U/g of insulin in the tail pancreas, the stability of the fasting serum glucose was very poor, indicating an unstable type of diabetes. There was a significant inverse correlation between standard deviation of FBS and the amount of insulin, but the PP content of the pancreas had no relation to the stability of the fasting serum glucose.

Adult↗