Search PubMed⌕ Search

Biomedical subjects

K Marks

Publications and source records attributed to K Marks.

30 records · Page 2Linked to original sources
PubMed1988

[Diagnosis and treatment of sacral and retrorectal tumors. II].

Forty-three sacral and retrorectal tumors encountered at the Cleveland Clinic were reviewed, with emphasis on incidence, diagnosis, and management. Benign tumors could be differentiated from malignant lesions on the basis of history, physical examination, and radiologic studies. CT scan and Magnetic Resonance Imaging are the most useful tests for staging. Small benign tumors may be removed through a posterior approach. All malignant lesions, and benign lesions greater than 3-4 cm in size should be removed through a combined anterior and posterior approach. All tumors should be completely removed wherever possible, since both benign and malignant tumors will recur when excision is incomplete. Radiotherapy and chemotherapy may provide some palliation for malignant tumors, but these modalities are not curative in our experience.

Adult↗
PubMed1987

A portable silicon photodiode luminometer.

A simple, inexpensive, battery-powered, portable luminometer which is based on a silicon photodiode is described. The instrument is intended to measure the light produced by chemiluminescent and bioluminescent reactions. The device shows a good detection limit and, in a bioluminescent reaction for adenosine 5'-triphosphate (ATP), detected 0.5 pmol in 1 ml of aqueous solution. The instrument measures irradiance from 10(-13) to 10(-11) W cm-2 at the sensor, within the range 300 to 900 nm.

Adenosine Triphosphate↗
PubMed1985

Interstitial deletion of chromosome 7p detected antenatally.

An interstitial deletion in chromosome 7(p13p15) detected in amniotic fluid cells is presented. After termination, the fetus was noted to have an asymmetrical skull, low set ears, a flattened nose, bifid thumbs and right big toe, pyloric adenomyosis, hypospadias, and simian creases. A brief comparison is made with previously reported cases involving deletions of 7p, including those associated with craniosynostosis.

Chromosome Deletion↗
PubMed1979

Möbius syndrome. Neuropathologic observations.

Neuropathologic findings in an infant with congenital right facial and bilateral lateral rectus palsy (Möbius syndrome) are presented. Multiple microscopic foci of necrosis were found in the lower pontine tegmentum, involving the region of the intramedullary course of 6th and 7th cranial nerves. The significance of pathologic findings in this infant and 14 additional published cases of Möbius syndrome is discussed.

Abducens Nerve↗
PubMed1977

Elective delivery of the term fetus. An obstetrical hazard.

Of 1,020 consecutive admissions to a regional neonatal center, 38 infants were admitted following elective delivery in which no medical condition of the mother or fetus had necessitated immediate delivery. Twenty infants had problems that were not primarily the result of elective delivery, developed in 18. Fifteen of these 18 infants were delivered by cesarean section; in none of the mothers had any assessment of fetal maturity or size (other than the menstrual history and physical examination) been made. The infants remained in the hospital for an average of 12.7 days at a median cost of $2,678 per patient. One infant died. In the absence of pressing medical indications and without an objective assessment of fetal maturity, elective delivery remains potentially hazardous.

Adult↗
PubMedDate not supplied

Results of infected total hip replacement arthroplasty.

Postoperative infection following total hip replacement and the complications associated with the treatment regimens are unsolved problems. The long term results of resection arthroplasties for infection in the older, debilitated individuals are poor insofar as patients may be destined to be either on crutches or bedfast for the duration of their lives.

Aged↗
PubMedDate not supplied

Mycobacterium bovis lymphadenitis complicating BCG immunization in an infant with symptomatic HIV-1 infection.

A 3-month-old infant with HIV-1 infection who recently immigrated from Ethiopia developed regional lymphadenitis and systemic symptoms subsequent to BCG immunization. She was suffering from axillary lymphadenitis ipsilateral to the BCG vaccination site, failure to thrive, unresolving fever and hepatosplenomegaly. Acid-fast bacilli were seen on staining and Mycobacterium bovis was isolated from the regional lymph node. The infant responded promptly to triple antituberculous therapy but died 2 months later from overwhelming pneumonia and respiratory failure. This case emphasizes the iatrogenic hazards of BCG immunization in HIV-1 infected infants. With the increasing prevalence of pediatric HIV-1 infection, indiscriminate BCG immunization programs should be reconsidered. While infants with asymptomatic HIV-1 infection at risk for tuberculosis should be immunized, BCG immunization should be withheld in those with symptomatic disease.

BCG Vaccine↗
PubMedDate not supplied

Transient neonatal diabetes mellitus in a child with invdup(6)(q22q23) of paternal origin.

An association between the rare condition of transient neonatal diabetes mellitus and either uniparental disomy for chromosome 6 or dup(6)(q22q23) raised the assumption that in this location on chromosome 6 there is an imprinted gene. We diagnosed diabetes that developed in a baby girl immediately after birth and resolved after 7 weeks of insulin treatment. Due to some minor dysmorphic features, we investigated her karyotype and identified invdup(6)(q22q23). The duplication spans at least 10 cM including the DNA sites DS270,S314,S1684 and S310. This case further supports the assumption that an imprinted gene exists on chromosome 6q22-23.

Child, Preschool↗