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Biomedical subjects

K Markley

Publications and source records attributed to K Markley.

31 records · Page 2Linked to original sources
PubMed1968

Protection by vaccination against Pseudomonas infection after thermal injury.

Active immunization is effective in the prophylaxis of Pseudomonas septicemia in burned mice. Vaccines were prepared from bacterial cells and growth medium of Verder's 10 different O serological types of Pseudomonas aeruginosa strains, as well as from Escherichia coli and Proteus mirabilis. Mice given a tail burn could be significantly protected against a local Pseudomonas challenge by both specific and, to a lesser extent, by nonspecific Pseudomonas vaccines prepared either from bacterial cells or from the medium in which they were grown. The vaccine was effective when administered prior to or after thermal trauma. After a more extensive rump burn, the protective effect of a specific vaccine given after thermal injury was significant only when the challenge was postponed until 4 days postburn; the level of protection was less than in the mice with smaller burns.

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PubMedDate not supplied

The role of histamine in burn, tourniquet and endotoxin shock in mice.

The release of histamine and mortality was studied in mice after various types of experimental shock. In burn shock, serum histamine rose significantly after injury, but there was no correlation between increased serum histamine and high mortality as a consequence of several therapy regimens. For example, after treatment with histamine or Compound 48/80 before burning, there was a rise of serum histamine, yet shock mortality fell significantly. Although separate administration of antagonists of H1 - or H2 - histamine receptors had no effect on mortality, pretreatment with both diphenhydramine and burimamide significantly increased shock mortality. In tourniquet shock, serum histamine rose significantly, and treatment with both antagonists before trauma produced a significant elevation of shock mortality. In endotoxin shock, prior treatment with one or both drugs did not change mortality. These results suggest that endogenous histamine is not a lethal factor in burn and tourniquet trauma, but rather it appears to have a compensatory, beneficial effect.

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