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Biomedical subjects

K Markiewicz

Publications and source records attributed to K Markiewicz.

223 records · Page 13Linked to original sources
PubMedDate not supplied

Adenine nucleotides and 2,3-dophosphoglycerate in the erythrocytes during physical exercise and restitution in healthy subjects.

The reported investigations were carried out in 6 young (20 years old) healthy males who performed a 10-minute exercise on a Monark cycle ergometer at workloads increasing the heart rate to 170/minute. Before the exercise, after its termination, and after 30 minutes of restitution the concentrations of adenosine-5' triphosphate, adenosine-5' diphosphate, adenosine-5' monophosphate, 2,3-diphosphoglycerate, nicotinamide-adenine dinucleotide and nicotinamide-adenine dinucleotide phosphate were assayed in erythrocytes. After the end of exercise a non-significant increase in ATP concentration and a non-significant decrease of 2,3-DPG were found in the erythrocytes. The concentrations of ADP and AMP were lower than at rest, both, after the end of exercise and after 30 minutes of restitution (p less than 0.05). The concentrations of nicotinamide-adenine dinucleotide and nicotinamide-adenine dinucleotide phosphate decreased after exercise (p less than 0.05) fell even more after 30 minutes of restitution (p less than 0.05).

Adenine Nucleotides↗
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Exercise effect on certain biochemical factors in the plasma in untrained subjects and in systematically trained cyclists.

Thirty-seven cyclists participating in long-distance road races were exposed to maximal exercise closely before the onset of racing season. Forty young males (medical students) of average physical fitness had similar exposure. In both groups determinations of the concentrations of free acids, glucose, amino acid nitrogen and lactate in the plasma of venous blood were done before the exercise, immediately after it, and in the 15th and 30th minutes of restitution. The differences between both groups were compared using the t test of Student. It was found that during maximal exercise glucose concentration increased more in the trained subjects than in the untrained ones, and remained increased at the restitution time. In the untrained subjects the concentrations of PFA and amino acid nitrogen decreased after the exercise, while in the group of cyclists it showed no significant changes. In contrast to the untrained group in the group of cyclists FFA concentrations decreased during restitution. Despite similar increase in heart rate and similar value of maximal workload in both groups the concentration of lactate was significantly lower in the group of cyclists.

Adult↗
PubMedDate not supplied

Effect of moderate hyperglycaemia on left-ventricular systolic time intervals during submaximal exercise of steady workload in healthy subjects.

The effect of submaximal exercise at steady workload on left-ventricular systolic time intervals (STI) was studied in healthy subjects. In group I (22 subjects) 20% glucose solution was injected intravenously in a dose of 2.5 ml/kg of body weight before the exercise. In group II (20 subjects) the same exercise was preceded by intravenous injection of normal saline 2.5 ml/kg of body weight. The left ventricular systolic time intervals were determined by the polycardiographic metod of Blumberger modified by Holldack and Weissler. It was found that glucose administration before the exercise improved myocardial contractility during the exercise. During hyperglycaemia the secondary impairment of myocardial contractility was less pronounced than in the control group. Postexercise changes in left ventricular systolic function regressed more rapidly in the group receiving glucose than in controls.

Adult↗
PubMedDate not supplied

The effect of glucagon on myoinositol levels in the blood serum and its excretion with urine.

The investigations were carried out with a group of ten healthy men aged 20--26 years who were injected intravenously with glucagon in a single dose of 50 microgram per kg of body weight. Glucagon had no effect on myoinositol levels in the blood serum. It caused however, a significant decrease in the myoinositol discharge into urine and lowered the index of renal myoinositol clearance. The creatinine clearance index remained unchanged.

Adult↗
PubMedDate not supplied

[Circadian rhythm of blood pressure and pulse rate in young men with diabetes mellitus type I depending on duration of disease].

In order to investigate the blood pressure-heart rate interrelation and their circadian pattern in type I diabetes mellitus, we performed ambulatory blood pressure monitoring in 28 normotensive patients without clinical nephropathy divided in two groups. Group A consisted of 14 males with short-term DM (mean 2 years, mean age 28 +/- 6 years), group B consisted of 14 males with long-term DM (mean 12 years, mean age 31 +/- 7 years). Ambulatory blood pressure monitoring revealed significantly higher night heart rate in B group (74 +/- 13 l/min vs. 62 +/- 11 l/min in A, p < 0.01) and day diastolic blood pressure (83 +/- 9 mm Hg vs. 74 +/- 8 mm Hg in A, p < 0.01) and night diastolic blood pressure (73 +/- 10 mm Hg vs. 62 +/- 8 mm Hg in A, p < 0.01). The linear regression SBP/HR equation were significantly different (p < 0.02) (HR = 0.48 x SBP + 21, r = 0.40 in A vs. HR = 0.29 x SBP + 69, r = 0.28 in B). We concluded that type I diabetes duration has significant influence on diastolic blood pressure and heart rate even in patients without diabetic nephropathy and could be related to changed sensitivity of the baroreceptors.

Adult↗
PubMedDate not supplied

[Effect of treatment with vasodilators on physical exercise tolerance in patients with chronic congestive heart failure].

The studies were performed in 46 patients with chronic congestive heart failure (CCHF), III and IV NYHA classes. During the first two weeks all patients received digoxin (D) and furosemide (F) in optimal doses (stage O). Then, patients were randomly divided into two groups. During the stage A group I (n = 26) received digoxin, furosemide and nifedipine (N), while in the stage B captopril (K) was added to that treatment and it was continued for 4 weeks. During the following two weeks (stage C) patients were treated the same as in stage A. During the same stages group II (n = 20) received D, F and isosorbide dinitrate (S), then, D, F, S and K followed by D, F and S, respectively. After the termination of each stage of the treatment all patients performed physical exercise on bicycle ergometer, until limiting symptoms have occurred. Power (M) and duration (t) of exercise, systolic (ps) and diastolic (Pd) arterial blood pressures, heart rate (HR) at the peak load, and HR x Ps and HR/M indices were determined. It was found that N did not significantly affect the investigated ergometric parameters. Combined treatment with D, F, N and K induced an increase in M, t and HR, and a decrease in. This effect persisted through the stage C. Following the treatment with D, F and S, a significant increase in M and decrease in HR/M were observed. Addition of K to D, F, and S did not induce further improvement in the physical exercise tolerance of these patients.

Adult↗