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Biomedical subjects

K Maki

Publications and source records attributed to K Maki.

At least 145 records · Page 8Linked to original sources
PubMed1990

Evaluation of pyrimido[5,4-d]pyrimidine derivatives as peroxyoxalate chemiluminescence reagents using a flow injection system.

Eighteen kinds of pyrimido[5,4-d]pyrimidines together with several commercially available fluorescent compounds such as perylene, Rhodamine B, etc., were evaluated as the reagents for a peroxyoxalate chemiluminescence (CL) detection system by using a flow injection method. The peroxyoxalate CL reaction employed consists of bis(2,4,6-trichlorophenyl)oxalate, hydrogen peroxide, triethylamine, and a fluorophore. Under the conditions used, 2,6-bis[di-(2-hydroxyethyl)amino]-4,8- dipiperidinopyrimido[5,4-d]pyrimidine (Dipyridamole) and 2,4,6,8-tetrathiomorpholinopyrimido[5,4-d]pyrimidine (1i) gave very intense chemiluminescence intensities which were larger than those of any other commercially available fluorescent compounds tested (e.g., 10 times larger than that of perylene).

Chromatography, High Pressure Liquid↗
PubMed1990

[An experimental study of the effect of food on osteoporosis especially on the mandible].

Three-week-old male rats of the Wistar strain given standard formed food (MF formed food) were grouped as controls. Those given calcium-deficient food for three weeks and then standard formed food after experimental osteoporosis induced in the rats were grouped as the experimental group. Experimental periods were for 4 and 6 weeks and the effect of the food on osteoporosis was investigated. The results were as follows: 1. Bone density of the alveolar bone showed significantly lower values for the experimental group than for the controls. 2. In comparison of relative Ca ratios (Ca/[Ca]c) and of P ratios (P/[P]c) on an X-ray microanalyzer, the controls showed higher values each week than the experimental group. 3. Compressive strength of the mandible in the experimental group decreased compared with the controls.

Animals↗