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Biomedical subjects

K Mai

Publications and source records attributed to K Mai.

At least 19 recordsLinked to original sources
PubMed1989

[Study on hepatitis delta virus infection in China].

Antibody to the delta antigen (anti-delta) was detected by using ELISA and RIA in 1027 HBsAg-positive persons distributed over 11 provinces, municipalities and autonomous regions in China. No positive of anti-delta was found in 634 cases in Beijing, Shanghai, Guangxi, Sichuan, Heilongjiang, Fujian, Liaonin, and Henan, of 393 cases in Inner Mongolia, Xinjiang and Tibet, 17 (4.3%) were positive. In these regions, the positive rate of anti-delta in CAH and CPH was much higher than that in chronic HBsAg carriers. It was suggested that HDV infection was characterized by endemic and sporadic features in China and it was important in the pathogenesis of chronic hepatitis B.

Antibodies, Viral↗
PubMed1986

Quantitation of the ultra short acting beta-adrenergic antagonist flestolol in blood by liquid chromatography.

A sensitive, specific, reproducible, and convenient high-performance liquid chromatographic (HPLC) assay was developed for quantitation of the new ultra short acting beta-adrenergic antagonist, flestolol (1), in whole blood. The instability of the compound in blood was overcome by the esterase inhibitor, NaF, and deproteinization of blood samples with CH3CN:CH2Cl2 (2:5). The internal standard was p-ethoxyphenethyl alcohol. The compounds were back extracted from the CH3CN:CH2Cl2 phase into a small volume of pH 3-4 phosphate buffer and then separated on a reversed-phase C18 column with 0.05 M phosphate buffer (pH 3-4) in acetonitrile (4.6:1) as the mobile phase, and detected with an UV detector at 229 nm. The assay was linear with a blood concentration range from 10 to 1270 ng/mL (r2 greater than 0.998, p greater than 0.01), and reproducible with an overall CV of 8%. The assay procedure was used to determine the blood levels of flestolol intravenously infused into a male dog for 105 min at 230 micrograms/kg/min. The steady-state unchanged drug concentration of 5 micrograms/mL in blood was achieved within 10-20 min and declined biexponentially to 0.02 microgram/mL at 6 h following termination of the infusion.

Adrenergic beta-Antagonists↗